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Protective effect of qiliqiangxin capsule on energy metabolism and myocardial mitochondria in pressure overload heart failure rats.

Zhang J, Wei C, Wang H, Tang S, Jia Z, Wang L, Xu D, Wu Y.

Evid Based Complement Alternat Med. 2013;2013:378298. doi: 10.1155/2013/378298. Epub 2013 Sep 2.


Qiliqiangxin inhibits the development of cardiac hypertrophy, remodeling, and dysfunction during 4 weeks of pressure overload in mice.

Zou Y, Lin L, Ye Y, Wei J, Zhou N, Liang Y, Gong H, Li L, Wu J, Li Y, Jia Z, Wu Y, Zhou J, Ge J.

J Cardiovasc Pharmacol. 2012 Mar;59(3):268-80. doi: 10.1097/FJC.0b013e31823f888f.


Cardiac insulin-resistance and decreased mitochondrial energy production precede the development of systolic heart failure after pressure-overload hypertrophy.

Zhang L, Jaswal JS, Ussher JR, Sankaralingam S, Wagg C, Zaugg M, Lopaschuk GD.

Circ Heart Fail. 2013 Sep 1;6(5):1039-48. doi: 10.1161/CIRCHEARTFAILURE.112.000228. Epub 2013 Jul 16.


PGC-1β deficiency accelerates the transition to heart failure in pressure overload hypertrophy.

Riehle C, Wende AR, Zaha VG, Pires KM, Wayment B, Olsen C, Bugger H, Buchanan J, Wang X, Moreira AB, Doenst T, Medina-Gomez G, Litwin SE, Lelliott CJ, Vidal-Puig A, Abel ED.

Circ Res. 2011 Sep 16;109(7):783-93. doi: 10.1161/CIRCRESAHA.111.243964. Epub 2011 Jul 28.


Combination Treatment With Antihypertensive Agents Enhances the Effect of Qiliqiangxin on Chronic Pressure Overload-induced Cardiac Hypertrophy and Remodeling in Male Mice.

Ye Y, Gong H, Wang X, Wu J, Wang S, Yuan J, Yin P, Jiang G, Li Y, Ding Z, Zhang W, Zhou J, Ge J, Zou Y.

J Cardiovasc Pharmacol. 2015 Jun;65(6):628-39. doi: 10.1097/FJC.0000000000000230.


Qiliqiangxin Enhances Cardiac Glucose Metabolism and Improves Diastolic Function in Spontaneously Hypertensive Rats.

Wang J, Li Z, Wang Y, Zhang J, Zhao W, Fu M, Han X, Zhou J, Ge J.

Evid Based Complement Alternat Med. 2017;2017:3197320. doi: 10.1155/2017/3197320. Epub 2017 Jun 19.


Cardio-protecteffect of qiliqiangxin capsule on left ventricular remodeling, dysfunction and apoptosis in heart failure rats after chronic myocardial infarction.

Liang T, Zhang Y, Yin S, Gan T, An T, Zhang R, Wang Y, Huang Y, Zhou Q, Zhang J.

Am J Transl Res. 2016 May 15;8(5):2047-58. eCollection 2016.


Decreased rates of substrate oxidation ex vivo predict the onset of heart failure and contractile dysfunction in rats with pressure overload.

Doenst T, Pytel G, Schrepper A, Amorim P, Färber G, Shingu Y, Mohr FW, Schwarzer M.

Cardiovasc Res. 2010 Jun 1;86(3):461-70. doi: 10.1093/cvr/cvp414. Epub 2009 Dec 24.


Induction of heart failure by minimally invasive aortic constriction in mice: reduced peroxisome proliferator-activated receptor γ coactivator levels and mitochondrial dysfunction.

Faerber G, Barreto-Perreia F, Schoepe M, Gilsbach R, Schrepper A, Schwarzer M, Mohr FW, Hein L, Doenst T.

J Thorac Cardiovasc Surg. 2011 Feb;141(2):492-500, 500.e1. doi: 10.1016/j.jtcvs.2010.03.029. Epub 2010 May 5.


Qiliqiangxin Attenuates Phenylephrine-Induced Cardiac Hypertrophy through Downregulation of MiR-199a-5p.

Zhang H, Li S, Zhou Q, Sun Q, Shen S, Zhou Y, Bei Y, Li X.

Cell Physiol Biochem. 2016;38(5):1743-51. doi: 10.1159/000443113. Epub 2016 May 9.


Adiponectin deficiency exacerbates cardiac dysfunction following pressure overload through disruption of an AMPK-dependent angiogenic response.

Shimano M, Ouchi N, Shibata R, Ohashi K, Pimentel DR, Murohara T, Walsh K.

J Mol Cell Cardiol. 2010 Aug;49(2):210-20. doi: 10.1016/j.yjmcc.2010.02.021. Epub 2010 Mar 4.


Pressure-overload-induced heart failure induces a selective reduction in glucose oxidation at physiological afterload.

Zhabyeyev P, Gandhi M, Mori J, Basu R, Kassiri Z, Clanachan A, Lopaschuk GD, Oudit GY.

Cardiovasc Res. 2013 Mar 15;97(4):676-85. doi: 10.1093/cvr/cvs424. Epub 2012 Dec 19.


Qiliqiangxin improves cardiac function and attenuates cardiac remodeling in rats with experimental myocardial infarction.

Wang J, Zhou J, Ding X, Zhu L, Jiang K, Fu M, Wang S, Hu K, Ge J.

Int J Clin Exp Pathol. 2015 Jun 1;8(6):6596-606. eCollection 2015.


Qiliqiangxin affects L type ca(2+) current in the normal and hypertrophied rat heart.

Wei Y, Liu X, Hou L, Che W, The E, Jhummon MV.

Evid Based Complement Alternat Med. 2012;2012:131830. doi: 10.1155/2012/131830. Epub 2012 Mar 26.


Maintaining PGC-1α expression following pressure overload-induced cardiac hypertrophy preserves angiogenesis but not contractile or mitochondrial function.

Pereira RO, Wende AR, Crum A, Hunter D, Olsen CD, Rawlings T, Riehle C, Ward WF, Abel ED.

FASEB J. 2014 Aug;28(8):3691-702. doi: 10.1096/fj.14-253823. Epub 2014 Apr 28.


Effect of metformin therapy on cardiac function and survival in a volume-overload model of heart failure in rats.

Benes J, Kazdova L, Drahota Z, Houstek J, Medrikova D, Kopecky J, Kovarova N, Vrbacky M, Sedmera D, Strnad H, Kolar M, Petrak J, Benada O, Skaroupkova P, Cervenka L, Melenovsky V.

Clin Sci (Lond). 2011 Jul;121(1):29-41. doi: 10.1042/CS20100527.


Diabetic db/db mice do not develop heart failure upon pressure overload: a longitudinal in vivo PET, MRI, and MRS study on cardiac metabolic, structural, and functional adaptations.

Abdurrachim D, Nabben M, Hoerr V, Kuhlmann MT, Bovenkamp P, Ciapaite J, Geraets IME, Coumans W, Luiken JJFP, Glatz JFC, Schäfers M, Nicolay K, Faber C, Hermann S, Prompers JJ.

Cardiovasc Res. 2017 Aug 1;113(10):1148-1160. doi: 10.1093/cvr/cvx100.


PGC-1 alpha regulates expression of myocardial mitochondrial antioxidants and myocardial oxidative stress after chronic systolic overload.

Lu Z, Xu X, Hu X, Fassett J, Zhu G, Tao Y, Li J, Huang Y, Zhang P, Zhao B, Chen Y.

Antioxid Redox Signal. 2010 Oct 1;13(7):1011-22. doi: 10.1089/ars.2009.2940.


Chronic treatment with qiliqiangxin ameliorates aortic endothelial cell dysfunction in diabetic rats.

Chen F, Wu JL, Fu GS, Mou Y, Hu SJ.

J Cardiovasc Pharmacol Ther. 2015 Mar;20(2):230-40. doi: 10.1177/1074248414537705. Epub 2014 Jun 6.


Cardiac-specific deletion of acetyl CoA carboxylase 2 prevents metabolic remodeling during pressure-overload hypertrophy.

Kolwicz SC Jr, Olson DP, Marney LC, Garcia-Menendez L, Synovec RE, Tian R.

Circ Res. 2012 Aug 31;111(6):728-38. doi: 10.1161/CIRCRESAHA.112.268128. Epub 2012 Jun 22.

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