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Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.

Sung B, Ravindran J, Prasad S, Pandey MK, Aggarwal BB.

J Biol Chem. 2010 Nov 12;285(46):35418-27. doi: 10.1074/jbc.M110.172767. Epub 2010 Sep 13. Retraction in: Sung B, Ravindran J, Prasad S, Pandey MK, Aggarwal BB. J Biol Chem. 2016 Aug 5;291(32):16923.


Capsazepine, a TRPV1 antagonist, sensitizes colorectal cancer cells to apoptosis by TRAIL through ROS-JNK-CHOP-mediated upregulation of death receptors.

Sung B, Prasad S, Ravindran J, Yadav VR, Aggarwal BB.

Free Radic Biol Med. 2012 Nov 15;53(10):1977-87. doi: 10.1016/j.freeradbiomed.2012.08.012. Epub 2012 Aug 15.


Zyflamend sensitizes tumor cells to TRAIL-induced apoptosis through up-regulation of death receptors and down-regulation of survival proteins: role of ROS-dependent CCAAT/enhancer-binding protein-homologous protein pathway.

Kim JH, Park B, Gupta SC, Kannappan R, Sung B, Aggarwal BB.

Antioxid Redox Signal. 2012 Mar 1;16(5):413-27. doi: 10.1089/ars.2011.3982. Epub 2011 Dec 15. Erratum in: Antioxid Redox Signal. 2013 Jan 10;18(2):219-20.


Tanshinone IIA Facilitates TRAIL Sensitization by Up-regulating DR5 through the ROS-JNK-CHOP Signaling Axis in Human Ovarian Carcinoma Cell Lines.

Chang CC, Kuan CP, Lin JY, Lai JS, Ho TF.

Chem Res Toxicol. 2015 Aug 17;28(8):1574-83. doi: 10.1021/acs.chemrestox.5b00150. Epub 2015 Jul 31.


The herbal compound cryptotanshinone restores sensitivity in cancer cells that are resistant to the tumor necrosis factor-related apoptosis-inducing ligand.

Tse AK, Chow KY, Cao HH, Cheng CY, Kwan HY, Yu H, Zhu GY, Wu YC, Fong WF, Yu ZL.

J Biol Chem. 2013 Oct 11;288(41):29923-33. doi: 10.1074/jbc.M113.483909. Epub 2013 Aug 28.


ROS and CHOP are critical for dibenzylideneacetone to sensitize tumor cells to TRAIL through induction of death receptors and downregulation of cell survival proteins.

Prasad S, Yadav VR, Ravindran J, Aggarwal BB.

Cancer Res. 2011 Jan 15;71(2):538-49. doi: 10.1158/0008-5472.CAN-10-3121. Epub 2010 Dec 2.


Gamma-tocotrienol promotes TRAIL-induced apoptosis through reactive oxygen species/extracellular signal-regulated kinase/p53-mediated upregulation of death receptors.

Kannappan R, Ravindran J, Prasad S, Sung B, Yadav VR, Reuter S, Chaturvedi MM, Aggarwal BB.

Mol Cancer Ther. 2010 Aug;9(8):2196-207. doi: 10.1158/1535-7163.MCT-10-0277. Epub 2010 Aug 3.


Cardamonin sensitizes tumour cells to TRAIL through ROS- and CHOP-mediated up-regulation of death receptors and down-regulation of survival proteins.

Yadav VR, Prasad S, Aggarwal BB.

Br J Pharmacol. 2012 Feb;165(3):741-53. doi: 10.1111/j.1476-5381.2011.01603.x. Erratum in: Br J Pharmacol. 2013 Jan;168(1):276-8.


Ilimaquinone induces death receptor expression and sensitizes human colon cancer cells to TRAIL-induced apoptosis through activation of ROS-ERK/p38 MAPK-CHOP signaling pathways.

Do MT, Na M, Kim HG, Khanal T, Choi JH, Jin SW, Oh SH, Hwang IH, Chung YC, Kim HS, Jeong TC, Jeong HG.

Food Chem Toxicol. 2014 Sep;71:51-9. doi: 10.1016/j.fct.2014.06.001. Epub 2014 Jun 12.


Verrucarin A sensitizes TRAIL-induced apoptosis via the upregulation of DR5 in an eIF2╬▒/CHOP-dependent manner.

Moon DO, Asami Y, Long H, Jang JH, Bae EY, Kim BY, Choi YH, Kang CH, Ahn JS, Kim GY.

Toxicol In Vitro. 2013 Feb;27(1):257-63. doi: 10.1016/j.tiv.2012.09.001. Epub 2012 Sep 12.


Anti-gout agent allopurinol exerts cytotoxicity to human hormone-refractory prostate cancer cells in combination with tumor necrosis factor-related apoptosis-inducing ligand.

Yasuda T, Yoshida T, Goda AE, Horinaka M, Yano K, Shiraishi T, Wakada M, Mizutani Y, Miki T, Sakai T.

Mol Cancer Res. 2008 Dec;6(12):1852-60. doi: 10.1158/1541-7786.MCR-08-0012.


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