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Items: 1 to 20 of 161

1.

TRIAD1 and HHARI bind to and are activated by distinct neddylated Cullin-RING ligase complexes.

Kelsall IR, Duda DM, Olszewski JL, Hofmann K, Knebel A, Langevin F, Wood N, Wightman M, Schulman BA, Alpi AF.

EMBO J. 2013 Oct 30;32(21):2848-60. doi: 10.1038/emboj.2013.209. Epub 2013 Sep 27.

2.

UBCH7 reactivity profile reveals parkin and HHARI to be RING/HECT hybrids.

Wenzel DM, Lissounov A, Brzovic PS, Klevit RE.

Nature. 2011 Jun 2;474(7349):105-8. doi: 10.1038/nature09966. Epub 2011 May 1.

3.

Two Distinct Types of E3 Ligases Work in Unison to Regulate Substrate Ubiquitylation.

Scott DC, Rhee DY, Duda DM, Kelsall IR, Olszewski JL, Paulo JA, de Jong A, Ovaa H, Alpi AF, Harper JW, Schulman BA.

Cell. 2016 Aug 25;166(5):1198-1214.e24. doi: 10.1016/j.cell.2016.07.027.

4.

Structure of a HOIP/E2~ubiquitin complex reveals RBR E3 ligase mechanism and regulation.

Lechtenberg BC, Rajput A, Sanishvili R, Dobaczewska MK, Ware CF, Mace PD, Riedl SJ.

Nature. 2016 Jan 28;529(7587):546-50. doi: 10.1038/nature16511. Epub 2016 Jan 20.

5.

Two functionally distinct E2/E3 pairs coordinate sequential ubiquitination of a common substrate in Caenorhabditis elegans development.

Dove KK, Kemp HA, Di Bona KR, Reiter KH, Milburn LJ, Camacho D, Fay DS, Miller DL, Klevit RE.

Proc Natl Acad Sci U S A. 2017 Aug 8;114(32):E6576-E6584. doi: 10.1073/pnas.1705060114. Epub 2017 Jul 24.

6.

Molecular insights into RBR E3 ligase ubiquitin transfer mechanisms.

Dove KK, Stieglitz B, Duncan ED, Rittinger K, Klevit RE.

EMBO Rep. 2016 Aug;17(8):1221-35. doi: 10.15252/embr.201642641. Epub 2016 Jun 16.

7.

Structural insights into the mechanism and E2 specificity of the RBR E3 ubiquitin ligase HHARI.

Yuan L, Lv Z, Atkison JH, Olsen SK.

Nat Commun. 2017 Aug 8;8(1):211. doi: 10.1038/s41467-017-00272-6.

8.

RING-Between-RING E3 Ligases: Emerging Themes amid the Variations.

Dove KK, Klevit RE.

J Mol Biol. 2017 Nov 10;429(22):3363-3375. doi: 10.1016/j.jmb.2017.08.008. Epub 2017 Aug 19. Review.

PMID:
28827147
9.

Structural Studies of HHARI/UbcH7∼Ub Reveal Unique E2∼Ub Conformational Restriction by RBR RING1.

Dove KK, Olszewski JL, Martino L, Duda DM, Wu XS, Miller DJ, Reiter KH, Rittinger K, Schulman BA, Klevit RE.

Structure. 2017 Jun 6;25(6):890-900.e5. doi: 10.1016/j.str.2017.04.013. Epub 2017 May 25.

10.

Structure of HHARI, a RING-IBR-RING ubiquitin ligase: autoinhibition of an Ariadne-family E3 and insights into ligation mechanism.

Duda DM, Olszewski JL, Schuermann JP, Kurinov I, Miller DJ, Nourse A, Alpi AF, Schulman BA.

Structure. 2013 Jun 4;21(6):1030-41. doi: 10.1016/j.str.2013.04.019. Epub 2013 May 23.

11.

Cullin 5-RING E3 ubiquitin ligases, new therapeutic targets?

Lamsoul I, Uttenweiler-Joseph S, Moog-Lutz C, Lutz PG.

Biochimie. 2016 Mar;122:339-47. doi: 10.1016/j.biochi.2015.08.003. Epub 2015 Aug 4. Review.

PMID:
26253693
12.

Structure of the HHARI catalytic domain shows glimpses of a HECT E3 ligase.

Spratt DE, Mercier P, Shaw GS.

PLoS One. 2013 Aug 15;8(8):e74047. doi: 10.1371/journal.pone.0074047. eCollection 2013.

13.

Control of cullin-ring ubiquitin ligase activity by nedd8.

Deshaies RJ, Emberley ED, Saha A.

Subcell Biochem. 2010;54:41-56. doi: 10.1007/978-1-4419-6676-6_4. Review.

PMID:
21222272
14.

The ubiquitin ligase Triad1 inhibits myelopoiesis through UbcH7 and Ubc13 interacting domains.

Marteijn JA, van der Meer LT, Smit JJ, Noordermeer SM, Wissink W, Jansen P, Swarts HG, Hibbert RG, de Witte T, Sixma TK, Jansen JH, van der Reijden BA.

Leukemia. 2009 Aug;23(8):1480-9. doi: 10.1038/leu.2009.57. Epub 2009 Apr 2.

PMID:
19340006
15.

Targeting NEDD8-activated cullin-RING ligases for the treatment of cancer.

Soucy TA, Smith PG, Rolfe M.

Clin Cancer Res. 2009 Jun 15;15(12):3912-6. doi: 10.1158/1078-0432.CCR-09-0343. Epub 2009 Jun 9.

16.

Inactivation of the Cullin (CUL)-RING E3 ligase by the NEDD8-activating enzyme inhibitor MLN4924 triggers protective autophagy in cancer cells.

Luo Z, Pan Y, Jeong LS, Liu J, Jia L.

Autophagy. 2012 Nov;8(11):1677-9. doi: 10.4161/auto.21484. Epub 2012 Aug 9.

17.

The ubiquitin-conjugating enzymes UbcH7 and UbcH8 interact with RING finger/IBR motif-containing domains of HHARI and H7-AP1.

Moynihan TP, Ardley HC, Nuber U, Rose SA, Jones PF, Markham AF, Scheffner M, Robinson PA.

J Biol Chem. 1999 Oct 22;274(43):30963-8.

18.

Features of the parkin/ariadne-like ubiquitin ligase, HHARI, that regulate its interaction with the ubiquitin-conjugating enzyme, Ubch7.

Ardley HC, Tan NG, Rose SA, Markham AF, Robinson PA.

J Biol Chem. 2001 Jun 1;276(22):19640-7. Epub 2001 Mar 13.

19.

Structural regulation of cullin-RING ubiquitin ligase complexes.

Duda DM, Scott DC, Calabrese MF, Zimmerman ES, Zheng N, Schulman BA.

Curr Opin Struct Biol. 2011 Apr;21(2):257-64. doi: 10.1016/j.sbi.2011.01.003. Epub 2011 Feb 1. Review.

20.

Characterization of the role of COP9 signalosome in regulating cullin E3 ubiquitin ligase activity.

Choo YY, Boh BK, Lou JJ, Eng J, Leck YC, Anders B, Smith PG, Hagen T.

Mol Biol Cell. 2011 Dec;22(24):4706-15. doi: 10.1091/mbc.E11-03-0251. Epub 2011 Oct 19.

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