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Items: 1 to 20 of 85

1.

Synthesis of sterically encumbered 11β-aminoprogesterone derivatives and evaluation as 11β-hydroxysteroid dehydrogenase inhibitors and mineralocorticoid receptor antagonists.

Pandya K, Dietrich D, Seibert J, Vederas JC, Odermatt A.

Bioorg Med Chem. 2013 Nov 1;21(21):6274-81. doi: 10.1016/j.bmc.2013.08.068. Epub 2013 Sep 7.

PMID:
24074876
2.
3.

11Beta-hydroxysteroid dehydrogenase, mineralocorticoid receptor, and thiazide-sensitive Na-Cl cotransporter expression by distal tubules.

Bostanjoglo M, Reeves WB, Reilly RF, Velázquez H, Robertson N, Litwack G, Morsing P, Dørup J, Bachmann S, Ellison DH.

J Am Soc Nephrol. 1998 Aug;9(8):1347-58. Erratum in: J Am Soc Nephrol 1998 Nov;9(11):2179. Bostonjoglo M [corrected to Bostanjoglo M].

4.

Distribution of glucocorticoid and mineralocorticoid receptors and 11beta-hydroxysteroid dehydrogenases in human and rat ocular tissues.

Stokes J, Noble J, Brett L, Phillips C, Seckl JR, O'Brien C, Andrew R.

Invest Ophthalmol Vis Sci. 2000 Jun;41(7):1629-38.

PMID:
10845579
5.

Tissue-specific modulation of mineralocorticoid receptor function by 11β-hydroxysteroid dehydrogenases: an overview.

Odermatt A, Kratschmar DV.

Mol Cell Endocrinol. 2012 Mar 24;350(2):168-86. doi: 10.1016/j.mce.2011.07.020. Epub 2011 Jul 22. Review.

PMID:
21820034
6.

Corticosteroid receptors and 11beta-hydroxysteroid dehydrogenase isoforms in rat intestinal epithelia.

Sheppard KE, Li KX, Autelitano DJ.

Am J Physiol. 1999 Sep;277(3 Pt 1):G541-7.

7.

Virtual screening as a strategy for the identification of xenobiotics disrupting corticosteroid action.

Nashev LG, Vuorinen A, Praxmarer L, Chantong B, Cereghetti D, Winiger R, Schuster D, Odermatt A.

PLoS One. 2012;7(10):e46958. doi: 10.1371/journal.pone.0046958. Epub 2012 Oct 4.

8.

Mineralocorticoid and glucocorticoid receptors differentially regulate NF-kappaB activity and pro-inflammatory cytokine production in murine BV-2 microglial cells.

Chantong B, Kratschmar DV, Nashev LG, Balazs Z, Odermatt A.

J Neuroinflammation. 2012 Nov 28;9:260. doi: 10.1186/1742-2094-9-260.

9.

Synthesis of novel 3-amino and 29-hydroxamic acid derivatives of glycyrrhetinic acid as selective 11β-hydroxysteroid dehydrogenase 2 inhibitors.

Stanetty C, Czollner L, Koller I, Shah P, Gaware R, Cunha TD, Odermatt A, Jordis U, Kosma P, Classen-Houben D.

Bioorg Med Chem. 2010 Nov 1;18(21):7522-41. doi: 10.1016/j.bmc.2010.08.046. Epub 2010 Sep 28.

PMID:
20851614
10.

Type 1 11beta-hydroxysteroid dehydrogenase as universal drug target in metabolic diseases?

Oppermann U.

Endocr Metab Immune Disord Drug Targets. 2006 Sep;6(3):259-69. Review.

PMID:
17017977
11.

Synthesis of new glycyrrhetinic acid derived ring A azepanone, 29-urea and 29-hydroxamic acid derivatives as selective 11β-hydroxysteroid dehydrogenase 2 inhibitors.

Gaware R, Khunt R, Czollner L, Stanetty C, Da Cunha T, Kratschmar DV, Odermatt A, Kosma P, Jordis U, Classen-Houben D.

Bioorg Med Chem. 2011 Mar 15;19(6):1866-80. doi: 10.1016/j.bmc.2011.02.005. Epub 2011 Mar 2.

PMID:
21376605
12.

The intracellular localization of the mineralocorticoid receptor is regulated by 11beta-hydroxysteroid dehydrogenase type 2.

Odermatt A, Arnold P, Frey FJ.

J Biol Chem. 2001 Jul 27;276(30):28484-92. Epub 2001 May 11.

13.
14.

The role of 11beta-hydroxysteroid dehydrogenase in steroid hormone specificity.

Náray-Fejes-Tóth A, Colombowala IK, Fejes-Tóth G.

J Steroid Biochem Mol Biol. 1998 Apr;65(1-6):311-6. Review.

PMID:
9699885
16.

Differences in the determinants of eplerenone, spironolactone and aldosterone binding to the mineralocorticoid receptor.

Rogerson FM, Yao Y, Smith BJ, Fuller PJ.

Clin Exp Pharmacol Physiol. 2004 Oct;31(10):704-9.

PMID:
15554912
17.

11Beta-hydroxysteroid dehydrogenase type 2 and mineralocorticoid receptor in human fetal development.

Hirasawa G, Sasano H, Suzuki T, Takeyama J, Muramatu Y, Fukushima K, Hiwatashi N, Toyota T, Nagura H, Krozowski ZS.

J Clin Endocrinol Metab. 1999 Apr;84(4):1453-8.

PMID:
10199794
18.

Stimulation of testosterone production in rat Leydig cells by aldosterone is mineralocorticoid receptor mediated.

Ge RS, Dong Q, Sottas CM, Latif SA, Morris DJ, Hardy MP.

Mol Cell Endocrinol. 2005 Nov 24;243(1-2):35-42. Epub 2005 Sep 26.

PMID:
16188378
19.

Therapeutic manipulation of glucocorticoid metabolism in cardiovascular disease.

Hadoke PW, Iqbal J, Walker BR.

Br J Pharmacol. 2009 Mar;156(5):689-712. doi: 10.1111/j.1476-5381.2008.00047.x. Epub 2009 Feb 23. Review.

20.

Design, synthesis, and structure-activity relationships of dihydrofuran-2-one and dihydropyrrol-2-one derivatives as novel benzoxazin-3-one-based mineralocorticoid receptor antagonists.

Hasui T, Ohra T, Ohyabu N, Asano K, Matsui H, Mizukami A, Habuka N, Sogabe S, Endo S, Siedem CS, Tang TP, Gauthier C, De Meese LA, Boyd SA, Fukumoto S.

Bioorg Med Chem. 2013 Oct 1;21(19):5983-94. doi: 10.1016/j.bmc.2013.07.043. Epub 2013 Jul 31.

PMID:
23958516

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