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EZH2-shRNA-mediated upregulation of p21waf1/cip1 and its transcriptional enhancers with concomitant downmodulation of mutant p53 in pancreatic ductal adenocarcinoma.

Batchu RB, Qazi AM, Gruzdyn OV, Semaan A, Seward SM, Chamala S, Dhulipala VB, Bouwman DL, Weaver DW, Gruber SA.

Surgery. 2013 Oct;154(4):739-46; discussion 746-7. doi: 10.1016/j.surg.2013.06.041.


EZH2 blockade by RNA interference inhibits growth of ovarian cancer by facilitating re-expression of p21(waf1/cip1) and by inhibiting mutant p53.

Seward S, Semaan A, Qazi AM, Gruzdyn OV, Chamala S, Bryant CC, Kumar S, Cameron D, Sethi S, Ali-Fehmi R, Morris R, Bouwman DL, Munkarah AR, Weaver DW, Gruber SA, Batchu RB.

Cancer Lett. 2013 Aug 9;336(1):53-60. doi: 10.1016/j.canlet.2013.04.012. Epub 2013 Apr 18.


Enhancer of zeste homolog 2 silences microRNA-218 in human pancreatic ductal adenocarcinoma cells by inducing formation of heterochromatin.

Li CH, To KF, Tong JH, Xiao Z, Xia T, Lai PB, Chow SC, Zhu YX, Chan SL, Marquez VE, Chen Y.

Gastroenterology. 2013 May;144(5):1086-1097.e9. doi: 10.1053/j.gastro.2013.01.058. Epub 2013 Feb 7.


Restoration of E-cadherin expression in pancreatic ductal adenocarcinoma treated with microRNA-101.

Qazi AM, Gruzdyn O, Semaan A, Seward S, Chamala S, Dhulipala V, Sethi S, Ali-Fehmi R, Philip PA, Bouwman DL, Weaver DW, Gruber SA, Batchu RB.

Surgery. 2012 Oct;152(4):704-11; discussion 711-3. doi: 10.1016/j.surg.2012.07.020. Epub 2012 Sep 1.


Enhancer of zeste homolog 2 is overexpressed and contributes to epigenetic inactivation of p21 and phosphatase and tensin homolog in B-cell acute lymphoblastic leukemia.

Chen J, Li J, Han Q, Sun Z, Wang J, Wang S, Zhao RC.

Exp Biol Med (Maywood). 2012 Sep;237(9):1110-6. Epub 2012 Sep 6.


Overexpression of p21(WAF1/CIP1) is an early event in the development of pancreatic intraepithelial neoplasia.

Biankin AV, Kench JG, Morey AL, Lee CS, Biankin SA, Head DR, Hugh TB, Henshall SM, Sutherland RL.

Cancer Res. 2001 Dec 15;61(24):8830-7.


Laser capture microdissection of pancreatic ductal adeno-carcinoma cells to analyze EzH2 by Western Blot analysis.

Qazi AM, Aggarwal S, Steffer CS, Bouwman DL, Weaver DW, Gruber SA, Batchu RB.

Methods Mol Biol. 2011;755:245-56. doi: 10.1007/978-1-61779-163-5_20.


Loss of histone demethylase KDM6B enhances aggressiveness of pancreatic cancer through downregulation of C/EBPα.

Yamamoto K, Tateishi K, Kudo Y, Sato T, Yamamoto S, Miyabayashi K, Matsusaka K, Asaoka Y, Ijichi H, Hirata Y, Otsuka M, Nakai Y, Isayama H, Ikenoue T, Kurokawa M, Fukayama M, Kokudo N, Omata M, Koike K.

Carcinogenesis. 2014 Nov;35(11):2404-14. doi: 10.1093/carcin/bgu136. Epub 2014 Jun 19.


Transcriptional inhibition of p21WAF1/CIP1 gene (CDKN1) expression by survivin is at least partially p53-dependent: evidence for survivin acting as a transcription factor or co-factor.

Tang L, Ling X, Liu W, Das GM, Li F.

Biochem Biophys Res Commun. 2012 May 4;421(2):249-254. doi: 10.1016/j.bbrc.2012.03.147. Epub 2012 Apr 6.


EZH2 promotes E2F-driven SCLC tumorigenesis through modulation of apoptosis and cell-cycle regulation.

Hubaux R, Thu KL, Coe BP, MacAulay C, Lam S, Lam WL.

J Thorac Oncol. 2013 Aug;8(8):1102-6. doi: 10.1097/JTO.0b013e318298762f.


Molecular mechanisms involved in the synergistic interaction of the EZH2 inhibitor 3-deazaneplanocin A with gemcitabine in pancreatic cancer cells.

Avan A, Crea F, Paolicchi E, Funel N, Galvani E, Marquez VE, Honeywell RJ, Danesi R, Peters GJ, Giovannetti E.

Mol Cancer Ther. 2012 Aug;11(8):1735-46. doi: 10.1158/1535-7163.MCT-12-0037. Epub 2012 May 23.


Transcriptional regulation during p21WAF1/CIP1-induced apoptosis in human ovarian cancer cells.

Wu Q, Kirschmeier P, Hockenberry T, Yang TY, Brassard DL, Wang L, McClanahan T, Black S, Rizzi G, Musco ML, Mirza A, Liu S.

J Biol Chem. 2002 Sep 27;277(39):36329-37. Epub 2002 Jul 22.


Nuclear accumulation of p53 correlates significantly with clinical features and inversely with the expression of the cyclin-dependent kinase inhibitor p21(WAF1/CIP1) in pancreatic cancer.

Harada N, Gansauge S, Gansauge F, Gause H, Shimoyama S, Imaizumi T, Mattfeld T, Schoenberg MH, Beger HG.

Br J Cancer. 1997;76(3):299-305.


MicroRNA-101 inhibits growth of epithelial ovarian cancer by relieving chromatin-mediated transcriptional repression of p21(waf¹/cip¹).

Semaan A, Qazi AM, Seward S, Chamala S, Bryant CS, Kumar S, Morris R, Steffes CP, Bouwman DL, Munkarah AR, Weaver DW, Gruber SA, Batchu RB.

Pharm Res. 2011 Dec;28(12):3079-90. doi: 10.1007/s11095-011-0547-x. Epub 2011 Aug 5.


EZH2 is associated with malignant behavior in pancreatic IPMN via p27Kip1 downregulation.

Kuroki H, Hayashi H, Okabe H, Hashimoto D, Takamori H, Nakahara O, Nakagawa S, Fukushima Y, Chikamoto A, Beppu T, Hirota M, Iyama K, Baba H.

PLoS One. 2014 Aug 1;9(8):e100904. doi: 10.1371/journal.pone.0100904. eCollection 2014.


EZH2 coupled with HOTAIR to silence MicroRNA-34a by the induction of heterochromatin formation in human pancreatic ductal adenocarcinoma.

Li CH, Xiao Z, Tong JH, To KF, Fang X, Cheng AS, Chen Y.

Int J Cancer. 2017 Jan 1;140(1):120-129. doi: 10.1002/ijc.30414. Epub 2016 Sep 19.


Endogenous p21WAF1/CIP1 status predicts the response of human tumor cells to wild-type p53 and p21WAF1/CIP1 overexpression.

Kralj M, Husnjak K, Körbler T, Pavelić J.

Cancer Gene Ther. 2003 Jun;10(6):457-67.


Up-regulation of p21WAF1/CIP1 by small activating RNA inhibits the in vitro and in vivo growth of pancreatic cancer cells.

Zhang Z, Wang Z, Liu X, Wang J, Li F, Li C, Shan B.

Tumori. 2012 Nov;98(6):804-11. doi: 10.1700/1217.13507.


Inhibition enhancer of zeste homologue 2 promotes senescence and apoptosis induced by doxorubicin in p53 mutant gastric cancer cells.

Bai J, Ma M, Cai M, Xu F, Chen J, Wang G, Shuai X, Tao K.

Cell Prolif. 2014 Jun;47(3):211-8. doi: 10.1111/cpr.12103. Epub 2014 Apr 16.


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