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Items: 1 to 20 of 123

1.

Cancer stemness in Apc- vs. Apc/KRAS-driven intestinal tumorigenesis.

Ghazvini M, Sonneveld P, Kremer A, Franken P, Sacchetti A, Atlasi Y, Roth S, Joosten R, Smits R, Fodde R.

PLoS One. 2013 Sep 17;8(9):e73872. doi: 10.1371/journal.pone.0073872. eCollection 2013 Sep 17.

2.

Mutated K-ras(Asp12) promotes tumourigenesis in Apc(Min) mice more in the large than the small intestines, with synergistic effects between K-ras and Wnt pathways.

Luo F, Brooks DG, Ye H, Hamoudi R, Poulogiannis G, Patek CE, Winton DJ, Arends MJ.

Int J Exp Pathol. 2009 Oct;90(5):558-74. doi: 10.1111/j.1365-2613.2009.00667.x.

3.

Cancer stemness in Wnt-driven mammary tumorigenesis.

Monteiro J, Gaspar C, Richer W, Franken PF, Sacchetti A, Joosten R, Idali A, Brandao J, Decraene C, Fodde R.

Carcinogenesis. 2014 Jan;35(1):2-13. doi: 10.1093/carcin/bgt279. Epub 2013 Aug 16.

PMID:
23955540
4.

Role of oncogenic K-Ras in cancer stem cell activation by aberrant Wnt/β-catenin signaling.

Moon BS, Jeong WJ, Park J, Kim TI, Min do S, Choi KY.

J Natl Cancer Inst. 2014 Feb;106(2):djt373. doi: 10.1093/jnci/djt373.

PMID:
24491301
5.

BCL9-2 promotes early stages of intestinal tumor progression.

Brembeck FH, Wiese M, Zatula N, Grigoryan T, Dai Y, Fritzmann J, Birchmeier W.

Gastroenterology. 2011 Oct;141(4):1359-70, 1370.e1-3. doi: 10.1053/j.gastro.2011.06.039. Epub 2011 Jun 23.

PMID:
21703997
6.

APC and oncogenic KRAS are synergistic in enhancing Wnt signaling in intestinal tumor formation and progression.

Janssen KP, Alberici P, Fsihi H, Gaspar C, Breukel C, Franken P, Rosty C, Abal M, El Marjou F, Smits R, Louvard D, Fodde R, Robine S.

Gastroenterology. 2006 Oct;131(4):1096-109. Epub 2006 Aug 16. Erratum in: Gastroenterology. 2006 Dec;131(6):2029.

PMID:
17030180
7.

Cooperation between the thyroid hormone receptor TRalpha1 and the WNT pathway in the induction of intestinal tumorigenesis.

Kress E, Skah S, Sirakov M, Nadjar J, Gadot N, Scoazec JY, Samarut J, Plateroti M.

Gastroenterology. 2010 May;138(5):1863-74. doi: 10.1053/j.gastro.2010.01.041. Epub 2010 Jan 28.

PMID:
20114049
8.

Deletion of the WNT target and cancer stem cell marker CD44 in Apc(Min/+) mice attenuates intestinal tumorigenesis.

Zeilstra J, Joosten SP, Dokter M, Verwiel E, Spaargaren M, Pals ST.

Cancer Res. 2008 May 15;68(10):3655-61. doi: 10.1158/0008-5472.CAN-07-2940.

9.

APC loss-induced intestinal tumorigenesis in Drosophila: Roles of Ras in Wnt signaling activation and tumor progression.

Wang C, Zhao R, Huang P, Yang F, Quan Z, Xu N, Xi R.

Dev Biol. 2013 Jun 15;378(2):122-40. doi: 10.1016/j.ydbio.2013.03.020. Epub 2013 Apr 6.

10.

Troy, a tumor necrosis factor receptor family member, interacts with lgr5 to inhibit wnt signaling in intestinal stem cells.

Fafilek B, Krausova M, Vojtechova M, Pospichalova V, Tumova L, Sloncova E, Huranova M, Stancikova J, Hlavata A, Svec J, Sedlacek R, Luksan O, Oliverius M, Voska L, Jirsa M, Paces J, Kolar M, Krivjanska M, Klimesova K, Tlaskalova-Hogenova H, Korinek V.

Gastroenterology. 2013 Feb;144(2):381-91. doi: 10.1053/j.gastro.2012.10.048. Epub 2012 Nov 7.

PMID:
23142137
11.

A hypermorphic epithelial β-catenin mutation facilitates intestinal tumorigenesis in mice in response to compounding WNT-pathway mutations.

Buchert M, Rohde F, Eissmann M, Tebbutt N, Williams B, Tan CW, Owen A, Hirokawa Y, Gnann A, Orend G, Orner G, Dashwood RH, Heath JK, Ernst M, Janssen KP.

Dis Model Mech. 2015 Nov;8(11):1361-73. doi: 10.1242/dmm.019844. Epub 2015 Aug 6.

12.

Intestinal epithelial cell-specific CD98 expression regulates tumorigenesis in Apc(Min/+) mice.

Nguyen HT, Dalmasso G, Yan Y, Laroui H, Charania M, Ingersoll S, Ayyadurai S, Zhang Y, Sitaraman S, Merlin D.

Lab Invest. 2012 Aug;92(8):1203-12. doi: 10.1038/labinvest.2012.83. Epub 2012 May 28.

13.

Mutational activation of the RAS-RAF-MAPK and the Wnt pathway in small intestinal adenocarcinomas.

Bläker H, Helmchen B, Bönisch A, Aulmann S, Penzel R, Otto HF, Rieker RJ.

Scand J Gastroenterol. 2004 Aug;39(8):748-53.

PMID:
15513360
14.

Crypt stem cells as the cells-of-origin of intestinal cancer.

Barker N, Ridgway RA, van Es JH, van de Wetering M, Begthel H, van den Born M, Danenberg E, Clarke AR, Sansom OJ, Clevers H.

Nature. 2009 Jan 29;457(7229):608-11. doi: 10.1038/nature07602. Epub 2008 Dec 17.

PMID:
19092804
15.

Severe polyposis in Apc(1322T) mice is associated with submaximal Wnt signalling and increased expression of the stem cell marker Lgr5.

Lewis A, Segditsas S, Deheragoda M, Pollard P, Jeffery R, Nye E, Lockstone H, Davis H, Clark S, Stamp G, Poulsom R, Wright N, Tomlinson I.

Gut. 2010 Dec;59(12):1680-6. doi: 10.1136/gut.2009.193680. Epub 2010 Oct 6.

16.

The threshold level of adenomatous polyposis coli protein for mouse intestinal tumorigenesis.

Li Q, Ishikawa TO, Oshima M, Taketo MM.

Cancer Res. 2005 Oct 1;65(19):8622-7.

17.

Wnt/beta-catenin signaling in cancer stemness and malignant behavior.

Fodde R, Brabletz T.

Curr Opin Cell Biol. 2007 Apr;19(2):150-8. Epub 2007 Feb 16. Review.

PMID:
17306971
18.

Putative direct and indirect Wnt targets identified through consistent gene expression changes in APC-mutant intestinal adenomas from humans and mice.

Segditsas S, Sieber O, Deheragoda M, East P, Rowan A, Jeffery R, Nye E, Clark S, Spencer-Dene B, Stamp G, Poulsom R, Suraweera N, Silver A, Ilyas M, Tomlinson I.

Hum Mol Genet. 2008 Dec 15;17(24):3864-75. doi: 10.1093/hmg/ddn286. Epub 2008 Sep 9.

19.

TGF-beta receptor inactivation and mutant Kras induce intestinal neoplasms in mice via a beta-catenin-independent pathway.

Trobridge P, Knoblaugh S, Washington MK, Munoz NM, Tsuchiya KD, Rojas A, Song X, Ulrich CM, Sasazuki T, Shirasawa S, Grady WM.

Gastroenterology. 2009 May;136(5):1680-8.e7. doi: 10.1053/j.gastro.2009.01.066. Epub 2009 Feb 4.

20.

Interaction of Muc2 and Apc on Wnt signaling and in intestinal tumorigenesis: potential role of chronic inflammation.

Yang K, Popova NV, Yang WC, Lozonschi I, Tadesse S, Kent S, Bancroft L, Matise I, Cormier RT, Scherer SJ, Edelmann W, Lipkin M, Augenlicht L, Velcich A.

Cancer Res. 2008 Sep 15;68(18):7313-22. doi: 10.1158/0008-5472.CAN-08-0598.

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