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Items: 1 to 20 of 136

1.

Adaptor complex AP2/PICALM, through interaction with LC3, targets Alzheimer's APP-CTF for terminal degradation via autophagy.

Tian Y, Chang JC, Fan EY, Flajolet M, Greengard P.

Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):17071-6. doi: 10.1073/pnas.1315110110. Epub 2013 Sep 25.

2.

The convergence of endosomal and autophagosomal pathways: implications for APP-CTF degradation.

Tian Y, Chang JC, Greengard P, Flajolet M.

Autophagy. 2014 Apr;10(4):694-6. doi: 10.4161/auto.27802. Epub 2014 Jan 16.

3.

Role of phosphatidylinositol clathrin assembly lymphoid-myeloid leukemia (PICALM) in intracellular amyloid precursor protein (APP) processing and amyloid plaque pathogenesis.

Xiao Q, Gil SC, Yan P, Wang Y, Han S, Gonzales E, Perez R, Cirrito JR, Lee JM.

J Biol Chem. 2012 Jun 15;287(25):21279-89. doi: 10.1074/jbc.M111.338376. Epub 2012 Apr 26.

4.

Decreasing the expression of PICALM reduces endocytosis and the activity of β-secretase: implications for Alzheimer's disease.

Thomas RS, Henson A, Gerrish A, Jones L, Williams J, Kidd EJ.

BMC Neurosci. 2016 Jul 18;17(1):50. doi: 10.1186/s12868-016-0288-1.

5.

A small-molecule enhancer of autophagy decreases levels of Abeta and APP-CTF via Atg5-dependent autophagy pathway.

Tian Y, Bustos V, Flajolet M, Greengard P.

FASEB J. 2011 Jun;25(6):1934-42. doi: 10.1096/fj.10-175158. Epub 2011 Mar 2.

6.

Impaired autophagy and APP processing in Alzheimer's disease: The potential role of Beclin 1 interactome.

Salminen A, Kaarniranta K, Kauppinen A, Ojala J, Haapasalo A, Soininen H, Hiltunen M.

Prog Neurobiol. 2013 Jul-Aug;106-107:33-54. doi: 10.1016/j.pneurobio.2013.06.002. Epub 2013 Jul 1. Review.

PMID:
23827971
7.

High Fat Diet Enhances β-Site Cleavage of Amyloid Precursor Protein (APP) via Promoting β-Site APP Cleaving Enzyme 1/Adaptor Protein 2/Clathrin Complex Formation.

Maesako M, Uemura M, Tashiro Y, Sasaki K, Watanabe K, Noda Y, Ueda K, Asada-Utsugi M, Kubota M, Okawa K, Ihara M, Shimohama S, Uemura K, Kinoshita A.

PLoS One. 2015 Sep 28;10(9):e0131199. doi: 10.1371/journal.pone.0131199. eCollection 2015.

8.

Regulation of amyloid precursor protein processing by the Beclin 1 complex.

Jaeger PA, Pickford F, Sun CH, Lucin KM, Masliah E, Wyss-Coray T.

PLoS One. 2010 Jun 15;5(6):e11102. doi: 10.1371/journal.pone.0011102.

9.

Gypenoside XVII Enhances Lysosome Biogenesis and Autophagy Flux and Accelerates Autophagic Clearance of Amyloid-β through TFEB Activation.

Meng X, Luo Y, Liang T, Wang M, Zhao J, Sun G, Sun X.

J Alzheimers Dis. 2016 Apr 5;52(3):1135-50. doi: 10.3233/JAD-160096.

PMID:
27060963
10.

APP overexpression in the absence of NPC1 exacerbates metabolism of amyloidogenic proteins of Alzheimer's disease.

Maulik M, Peake K, Chung J, Wang Y, Vance JE, Kar S.

Hum Mol Genet. 2015 Dec 15;24(24):7132-50. doi: 10.1093/hmg/ddv413. Epub 2015 Oct 3.

11.

Cilostazol Upregulates Autophagy via SIRT1 Activation: Reducing Amyloid-β Peptide and APP-CTFβ Levels in Neuronal Cells.

Lee HR, Shin HK, Park SY, Kim HY, Bae SS, Lee WS, Rhim BY, Hong KW, Kim CD.

PLoS One. 2015 Aug 5;10(8):e0134486. doi: 10.1371/journal.pone.0134486. eCollection 2015.

12.

Tetrahydrohyperforin Inhibits the Proteolytic Processing of Amyloid Precursor Protein and Enhances Its Degradation by Atg5-Dependent Autophagy.

Cavieres VA, González A, Muñoz VC, Yefi CP, Bustamante HA, Barraza RR, Tapia-Rojas C, Otth C, Barrera MJ, González C, Mardones GA, Inestrosa NC, Burgos PV.

PLoS One. 2015 Aug 26;10(8):e0136313. doi: 10.1371/journal.pone.0136313. eCollection 2015.

13.

Macroautophagy is not directly involved in the metabolism of amyloid precursor protein.

Boland B, Smith DA, Mooney D, Jung SS, Walsh DM, Platt FM.

J Biol Chem. 2010 Nov 26;285(48):37415-26. doi: 10.1074/jbc.M110.186411. Epub 2010 Sep 23.

14.

IGF-1 promotes beta-amyloid production by a secretase-independent mechanism.

Araki W, Kume H, Oda A, Tamaoka A, Kametani F.

Biochem Biophys Res Commun. 2009 Feb 27;380(1):111-4. doi: 10.1016/j.bbrc.2009.01.044. Epub 2009 Jan 22.

PMID:
19167357
15.

Distribution and expression of picalm in Alzheimer disease.

Baig S, Joseph SA, Tayler H, Abraham R, Owen MJ, Williams J, Kehoe PG, Love S.

J Neuropathol Exp Neurol. 2010 Oct;69(10):1071-7. doi: 10.1097/NEN.0b013e3181f52e01.

16.

APP, APOE, complement receptor 1, clusterin and PICALM and their involvement in the herpes simplex life cycle.

Carter CJ.

Neurosci Lett. 2010 Oct 11;483(2):96-100. doi: 10.1016/j.neulet.2010.07.066. Epub 2010 Jul 30. Review.

PMID:
20674675
17.

[Alzheimer disease: cellular and molecular aspects].

Octave JN.

Bull Mem Acad R Med Belg. 2005;160(10-12):445-9; discussion 450-1. French.

PMID:
16768248
18.

New Insights to Clathrin and Adaptor Protein 2 for the Design and Development of Therapeutic Strategies.

Poulsen ET, Larsen A, Zollo A, Jørgensen AL, Sanggaard KW, Enghild JJ, Matrone C.

Int J Mol Sci. 2015 Dec 10;16(12):29446-53. doi: 10.3390/ijms161226181.

19.

The Role of PICALM in Alzheimer's Disease.

Xu W, Tan L, Yu JT.

Mol Neurobiol. 2015 Aug;52(1):399-413. doi: 10.1007/s12035-014-8878-3. Epub 2014 Sep 4. Review.

PMID:
25186232
20.

Clathrin adaptor CALM/PICALM is associated with neurofibrillary tangles and is cleaved in Alzheimer's brains.

Ando K, Brion JP, Stygelbout V, Suain V, Authelet M, Dedecker R, Chanut A, Lacor P, Lavaur J, Sazdovitch V, Rogaeva E, Potier MC, Duyckaerts C.

Acta Neuropathol. 2013 Jun;125(6):861-78. doi: 10.1007/s00401-013-1111-z. Epub 2013 Apr 16.

PMID:
23589030

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