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Factors that determine penumbral tissue loss in acute ischaemic stroke.

Jung S, Gilgen M, Slotboom J, El-Koussy M, Zubler C, Kiefer C, Luedi R, Mono ML, Heldner MR, Weck A, Mordasini P, Schroth G, Mattle HP, Arnold M, Gralla J, Fischer U.

Brain. 2013 Dec;136(Pt 12):3554-60. doi: 10.1093/brain/awt246.


SB 234551 selective ET(A) receptor antagonism: perfusion/diffusion MRI used to define treatable stroke model, time to treatment and mechanism of protection.

Legos JJ, Lenhard SC, Haimbach RE, Schaeffer TR, Bentley RG, McVey MJ, Chandra S, Irving EA, Andrew A Parsons, Barone FC.

Exp Neurol. 2008 Jul;212(1):53-62. doi: 10.1016/j.expneurol.2008.03.011.


Selection of thrombolytic therapy beyond 3 h using magnetic resonance imaging.

Davis SM, Donnan GA, Butcher KS, Parsons M.

Curr Opin Neurol. 2005 Feb;18(1):47-52. Review.


Effect of collateral blood flow on patients undergoing endovascular therapy for acute ischemic stroke.

Marks MP, Lansberg MG, Mlynash M, Olivot JM, Straka M, Kemp S, McTaggart R, Inoue M, Zaharchuk G, Bammer R, Albers GW; Diffusion and Perfusion Imaging Evaluation for Understanding Stroke Evolution 2 Investigators..

Stroke. 2014 Apr;45(4):1035-9. doi: 10.1161/STROKEAHA.113.004085.


Infarction of 'non-core-non-penumbral' tissue after stroke: multivariate modelling of clinical impact.

Alawneh JA, Jones PS, Mikkelsen IK, Cho TH, Siemonsen S, Mouridsen K, Ribe L, Morris RS, Hjort N, Antoun N, Gillard JH, Fiehler J, Nighoghossian N, Warburton EA, Ostergaard L, Baron JC.

Brain. 2011 Jun;134(Pt 6):1765-76. doi: 10.1093/brain/awr100.


The growth rate of early DWI lesions is highly variable and associated with penumbral salvage and clinical outcomes following endovascular reperfusion.

Wheeler HM, Mlynash M, Inoue M, Tipirnini A, Liggins J, Bammer R, Lansberg MG, Kemp S, Zaharchuk G, Straka M, Albers GW; DEFUSE 2 Investigators..

Int J Stroke. 2015 Jul;10(5):723-9. doi: 10.1111/ijs.12436.


Remote ischemic perconditioning in thrombolysed stroke patients: randomized study of activating endogenous neuroprotection - design and MRI measurements.

Hougaard KD, Hjort N, Zeidler D, Sørensen L, Nørgaard A, Thomsen RB, Jonsdottir K, Mouridsen K, Hansen TM, Cho TH, Nielsen TT, Bøtker HE, Østergaard L, Andersen G.

Int J Stroke. 2013 Feb;8(2):141-6. doi: 10.1111/j.1747-4949.2012.00786.x.


Time is Penumbra: imaging, selection and outcome. The Johann jacob wepfer award 2014.

Davis S, Donnan GA.

Cerebrovasc Dis. 2014;38(1):59-72. doi: 10.1159/000365503. Review.


Elevated T2-values in MRI of stroke patients shortly after symptom onset do not predict irreversible tissue infarction.

Siemonsen S, Löbel U, Sedlacik J, Forkert ND, Mouridsen K, Østergaard L, Thomalla G, Fiehler J.

Brain. 2012 Jun;135(Pt 6):1981-9. doi: 10.1093/brain/aws079.


[Application of diffusion-weighted and perfusion magnetic resonance imaging in definition of the ischemic penumbra in hyperacute cerebral infarction].

Feng XY, Liang J, Yin XD, Han X, Dong Q, Lü CZ.

Zhonghua Yi Xue Za Zhi. 2003 Jun 10;83(11):952-7. Chinese.


What is the relationship among penumbra volume, collaterals, and time since onset in the first 6 h after acute ischemic stroke?

Cheripelli BK, Huang X, McVerry F, Muir KW.

Int J Stroke. 2016 Apr;11(3):338-46. doi: 10.1177/1747493015620807.


Impact of collateral flow on tissue fate in acute ischaemic stroke.

Bang OY, Saver JL, Buck BH, Alger JR, Starkman S, Ovbiagele B, Kim D, Jahan R, Duckwiler GR, Yoon SR, Viñuela F, Liebeskind DS; UCLA Collateral Investigators..

J Neurol Neurosurg Psychiatry. 2008 Jun;79(6):625-9.


Large Volumes of Critically Hypoperfused Penumbral Tissue Do Not Preclude Good Outcomes After Complete Endovascular Reperfusion: Redefining Malignant Profile.

Nogueira RG, Haussen DC, Dehkharghani S, Rebello LC, Lima A, Bowen M, Belagaje S, Anderson A, Frankel M.

Stroke. 2016 Jan;47(1):94-8. doi: 10.1161/STROKEAHA.115.011360.


Optimal magnetic resonance perfusion thresholds identifying ischemic penumbra and infarct core: a Chinese population-based study.

Zhang S, Tang H, Yu YN, Yan SQ, Parsons MW, Lou M.

CNS Neurosci Ther. 2015 Mar;21(3):289-95. doi: 10.1111/cns.12367.


Optimal Tmax threshold for predicting penumbral tissue in acute stroke.

Olivot JM, Mlynash M, Thijs VN, Kemp S, Lansberg MG, Wechsler L, Bammer R, Marks MP, Albers GW.

Stroke. 2009 Feb;40(2):469-75. doi: 10.1161/STROKEAHA.108.526954.


3-Tesla versus 1.5-Tesla magnetic resonance diffusion and perfusion imaging in hyperacute ischemic stroke.

Kosior RK, Wright CJ, Kosior JC, Kenney C, Scott JN, Frayne R, Hill MD.

Cerebrovasc Dis. 2007;24(4):361-8.


Admission insular infarction >25% is the strongest predictor of large mismatch loss in proximal middle cerebral artery stroke.

Kamalian S, Kemmling A, Borgie RC, Morais LT, Payabvash S, Franceschi AM, Kamalian S, Yoo AJ, Furie KL, Lev MH.

Stroke. 2013 Nov;44(11):3084-9. doi: 10.1161/STROKEAHA.113.002260.


The existence and evolution of diffusion-perfusion mismatched tissue in white and gray matter after acute stroke.

Koga M, Reutens DC, Wright P, Phan T, Markus R, Pedreira B, Fitt G, Lim I, Donnan GA.

Stroke. 2005 Oct;36(10):2132-7.


Hyperintensity of distal vessels on FLAIR is associated with slow progression of the infarction in acute ischemic stroke.

Pérez de la Ossa N, Hernández-Pérez M, Domènech S, Cuadras P, Massuet A, Millán M, Gomis M, López-Cancio E, Dorado L, Dávalos A.

Cerebrovasc Dis. 2012;34(5-6):376-84. doi: 10.1159/000343658.


DWI reversal is associated with small infarct volume in patients with TIA and minor stroke.

Asdaghi N, Campbell BC, Butcher KS, Coulter JI, Modi J, Qazi A, Goyal M, Demchuk AM, Coutts SB.

AJNR Am J Neuroradiol. 2014 Apr;35(4):660-6. doi: 10.3174/ajnr.A3733.

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