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Items: 1 to 20 of 263

1.

Overexpression of synphilin-1 promotes clearance of soluble and misfolded alpha-synuclein without restoring the motor phenotype in aged A30P transgenic mice.

Casadei N, Pöhler AM, Tomás-Zapico C, Torres-Peraza J, Schwedhelm I, Witz A, Zamolo I, De Heer R, Spruijt B, Noldus LP, Klucken J, Lucas JJ, Kahle PJ, Krüger R, Riess O, Nuber S.

Hum Mol Genet. 2014 Feb 1;23(3):767-81. doi: 10.1093/hmg/ddt467.

PMID:
24064336
2.

alpha-Synuclein is colocalized with 14-3-3 and synphilin-1 in A53T transgenic mice.

Shirakashi Y, Kawamoto Y, Tomimoto H, Takahashi R, Ihara M.

Acta Neuropathol. 2006 Dec;112(6):681-9.

PMID:
16957925
3.

Aggregate formation and toxicity by wild-type and R621C synphilin-1 in the nigrostriatal system of mice using adenoviral vectors.

Krenz A, Falkenburger BH, Gerhardt E, Drinkut A, Schulz JB.

J Neurochem. 2009 Jan;108(1):139-46. doi: 10.1111/j.1471-4159.2008.05755.x.

4.

Synphilin-1 attenuates neuronal degeneration in the A53T alpha-synuclein transgenic mouse model.

Smith WW, Liu Z, Liang Y, Masuda N, Swing DA, Jenkins NA, Copeland NG, Troncoso JC, Pletnikov M, Dawson TM, Martin LJ, Moran TH, Lee MK, Borchelt DR, Ross CA.

Hum Mol Genet. 2010 Jun 1;19(11):2087-98. doi: 10.1093/hmg/ddq086.

5.

Synphilin isoforms and the search for a cellular model of lewy body formation in Parkinson's disease.

Eyal A, Engelender S.

Cell Cycle. 2006 Sep;5(18):2082-6. Review.

PMID:
16969096
6.

Aggresomes formed by alpha-synuclein and synphilin-1 are cytoprotective.

Tanaka M, Kim YM, Lee G, Junn E, Iwatsubo T, Mouradian MM.

J Biol Chem. 2004 Feb 6;279(6):4625-31.

7.

Synphilin-1A: an aggregation-prone isoform of synphilin-1 that causes neuronal death and is present in aggregates from alpha-synucleinopathy patients.

Eyal A, Szargel R, Avraham E, Liani E, Haskin J, Rott R, Engelender S.

Proc Natl Acad Sci U S A. 2006 Apr 11;103(15):5917-22.

8.

Transgenic overexpression of the alpha-synuclein interacting protein synphilin-1 leads to behavioral and neuropathological alterations in mice.

Nuber S, Franck T, Wolburg H, Schumann U, Casadei N, Fischer K, Calaminus C, Pichler BJ, Chanarat S, Teismann P, Schulz JB, Luft AR, Tomiuk J, Wilbertz J, Bornemann A, Krüger R, Riess O.

Neurogenetics. 2010 Feb;11(1):107-20. doi: 10.1007/s10048-009-0212-2.

PMID:
19760259
9.

Synphilin-1 associates with alpha-synuclein and promotes the formation of cytosolic inclusions.

Engelender S, Kaminsky Z, Guo X, Sharp AH, Amaravi RK, Kleiderlein JJ, Margolis RL, Troncoso JC, Lanahan AA, Worley PF, Dawson VL, Dawson TM, Ross CA.

Nat Genet. 1999 May;22(1):110-4.

PMID:
10319874
10.

Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease.

Chung KK, Zhang Y, Lim KL, Tanaka Y, Huang H, Gao J, Ross CA, Dawson VL, Dawson TM.

Nat Med. 2001 Oct;7(10):1144-50.

PMID:
11590439
11.

Ubiquitylation of synphilin-1 and alpha-synuclein by SIAH and its presence in cellular inclusions and Lewy bodies imply a role in Parkinson's disease.

Liani E, Eyal A, Avraham E, Shemer R, Szargel R, Berg D, Bornemann A, Riess O, Ross CA, Rott R, Engelender S.

Proc Natl Acad Sci U S A. 2004 Apr 13;101(15):5500-5.

12.

Synphilin-1 isoforms in Parkinson's disease: regulation by phosphorylation and ubiquitylation.

Szargel R, Rott R, Engelender S.

Cell Mol Life Sci. 2008 Jan;65(1):80-8. Review.

PMID:
17982729
13.

Interaction of alpha-synuclein and synphilin-1: effect of Parkinson's disease-associated mutations.

Kawamata H, McLean PJ, Sharma N, Hyman BT.

J Neurochem. 2001 May;77(3):929-34.

14.

Synphilin-1 transgenic mice exhibit mild motor impairments.

Jin HG, Yamashita H, Nakamura T, Fukuba H, Takahashi T, Hiji M, Kohriyama T, Matsumoto M.

Neurosci Lett. 2008 Nov 7;445(1):12-7. doi: 10.1016/j.neulet.2008.08.073.

PMID:
18782602
15.

Subcellular localization of wild-type and Parkinson's disease-associated mutant alpha -synuclein in human and transgenic mouse brain.

Kahle PJ, Neumann M, Ozmen L, Muller V, Jacobsen H, Schindzielorz A, Okochi M, Leimer U, van Der Putten H, Probst A, Kremmer E, Kretzschmar HA, Haass C.

J Neurosci. 2000 Sep 1;20(17):6365-73.

16.

Aggregate clearance of α-synuclein in Saccharomyces cerevisiae depends more on autophagosome and vacuole function than on the proteasome.

Petroi D, Popova B, Taheri-Talesh N, Irniger S, Shahpasandzadeh H, Zweckstetter M, Outeiro TF, Braus GH.

J Biol Chem. 2012 Aug 10;287(33):27567-79. doi: 10.1074/jbc.M112.361865.

17.

Mitochondrial associated metabolic proteins are selectively oxidized in A30P alpha-synuclein transgenic mice--a model of familial Parkinson's disease.

Poon HF, Frasier M, Shreve N, Calabrese V, Wolozin B, Butterfield DA.

Neurobiol Dis. 2005 Apr;18(3):492-8.

PMID:
15755676
18.

Changes in adult olfactory bulb neurogenesis in mice expressing the A30P mutant form of alpha-synuclein.

Marxreiter F, Nuber S, Kandasamy M, Klucken J, Aigner R, Burgmayer R, Couillard-Despres S, Riess O, Winkler J, Winner B.

Eur J Neurosci. 2009 Mar;29(5):879-90. doi: 10.1111/j.1460-9568.2009.06641.x.

PMID:
19291219
19.
20.
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