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Items: 1 to 20 of 99

1.

A propofol binding site on mammalian GABAA receptors identified by photolabeling.

Yip GM, Chen ZW, Edge CJ, Smith EH, Dickinson R, Hohenester E, Townsend RR, Fuchs K, Sieghart W, Evers AS, Franks NP.

Nat Chem Biol. 2013 Nov;9(11):715-20. doi: 10.1038/nchembio.1340. Epub 2013 Sep 22.

2.

Multiple propofol-binding sites in a γ-aminobutyric acid type A receptor (GABAAR) identified using a photoreactive propofol analog.

Jayakar SS, Zhou X, Chiara DC, Dostalova Z, Savechenkov PY, Bruzik KS, Dailey WP, Miller KW, Eckenhoff RG, Cohen JB.

J Biol Chem. 2014 Oct 3;289(40):27456-68. doi: 10.1074/jbc.M114.581728. Epub 2014 Aug 1.

3.

Anaesthetic binding sites for etomidate and propofol on a GABAA receptor model.

Campagna-Slater V, Weaver DF.

Neurosci Lett. 2007 May 11;418(1):28-33. Epub 2007 Mar 19.

PMID:
17412502
5.

Mapping general anesthetic binding site(s) in human α1β3 γ-aminobutyric acid type A receptors with [³H]TDBzl-etomidate, a photoreactive etomidate analogue.

Chiara DC, Dostalova Z, Jayakar SS, Zhou X, Miller KW, Cohen JB.

Biochemistry. 2012 Jan 31;51(4):836-47. doi: 10.1021/bi201772m. Epub 2012 Jan 23.

6.

Neurosteroid analog photolabeling of a site in the third transmembrane domain of the β3 subunit of the GABA(A) receptor.

Chen ZW, Manion B, Townsend RR, Reichert DE, Covey DF, Steinbach JH, Sieghart W, Fuchs K, Evers AS.

Mol Pharmacol. 2012 Sep;82(3):408-19. doi: 10.1124/mol.112.078410. Epub 2012 May 30.

7.

Neurosteroids allosterically modulate binding of the anesthetic etomidate to gamma-aminobutyric acid type A receptors.

Li GD, Chiara DC, Cohen JB, Olsen RW.

J Biol Chem. 2009 May 1;284(18):11771-5. doi: 10.1074/jbc.C900016200. Epub 2009 Mar 12.

8.

Positive and Negative Allosteric Modulation of an α1β3γ2 γ-Aminobutyric Acid Type A (GABAA) Receptor by Binding to a Site in the Transmembrane Domain at the γ+-β- Interface.

Jayakar SS, Zhou X, Savechenkov PY, Chiara DC, Desai R, Bruzik KS, Miller KW, Cohen JB.

J Biol Chem. 2015 Sep 18;290(38):23432-46. doi: 10.1074/jbc.M115.672006. Epub 2015 Jul 30.

9.

Numerous classes of general anesthetics inhibit etomidate binding to gamma-aminobutyric acid type A (GABAA) receptors.

Li GD, Chiara DC, Cohen JB, Olsen RW.

J Biol Chem. 2010 Mar 19;285(12):8615-20. doi: 10.1074/jbc.M109.074708. Epub 2010 Jan 18.

10.

Mutational Analysis of the Putative High-Affinity Propofol Binding Site in Human β3 Homomeric GABAA Receptors.

Eaton MM, Cao LQ, Chen Z, Franks NP, Evers AS, Akk G.

Mol Pharmacol. 2015 Oct;88(4):736-45. doi: 10.1124/mol.115.100347. Epub 2015 Jul 23.

11.

Specificity of intersubunit general anesthetic-binding sites in the transmembrane domain of the human α1β3γ2 γ-aminobutyric acid type A (GABAA) receptor.

Chiara DC, Jayakar SS, Zhou X, Zhang X, Savechenkov PY, Bruzik KS, Miller KW, Cohen JB.

J Biol Chem. 2013 Jul 5;288(27):19343-57. doi: 10.1074/jbc.M113.479725. Epub 2013 May 15.

12.
13.

Multiple Non-Equivalent Interfaces Mediate Direct Activation of GABAA Receptors by Propofol.

Eaton MM, Germann AL, Arora R, Cao LQ, Gao X, Shin DJ, Wu A, Chiara DC, Cohen JB, Steinbach JH, Evers AS, Akk G.

Curr Neuropharmacol. 2016;14(7):772-80. Review.

14.

A Novel Bifunctional Alkylphenol Anesthetic Allows Characterization of γ-Aminobutyric Acid, Type A (GABAA), Receptor Subunit Binding Selectivity in Synaptosomes.

Woll KA, Murlidaran S, Pinch BJ, Hénin J, Wang X, Salari R, Covarrubias M, Dailey WP, Brannigan G, Garcia BA, Eckenhoff RG.

J Biol Chem. 2016 Sep 23;291(39):20473-86. doi: 10.1074/jbc.M116.736975. Epub 2016 Jul 26.

15.

Identification of propofol binding sites in a nicotinic acetylcholine receptor with a photoreactive propofol analog.

Jayakar SS, Dailey WP, Eckenhoff RG, Cohen JB.

J Biol Chem. 2013 Mar 1;288(9):6178-89. doi: 10.1074/jbc.M112.435909. Epub 2013 Jan 8.

16.

Photoaffinity labeling the propofol binding site in GLIC.

Chiara DC, Gill JF, Chen Q, Tillman T, Dailey WP, Eckenhoff RG, Xu Y, Tang P, Cohen JB.

Biochemistry. 2014 Jan 14;53(1):135-42. doi: 10.1021/bi401492k. Epub 2013 Dec 30.

17.

Identification of a GABAA receptor anesthetic binding site at subunit interfaces by photolabeling with an etomidate analog.

Li GD, Chiara DC, Sawyer GW, Husain SS, Olsen RW, Cohen JB.

J Neurosci. 2006 Nov 8;26(45):11599-605.

18.
19.

A residue in loop 9 of the beta2-subunit stabilizes the closed state of the GABAA receptor.

Williams CA, Bell SV, Jenkins A.

J Biol Chem. 2010 Mar 5;285(10):7281-7. doi: 10.1074/jbc.M109.050294. Epub 2009 Dec 10.

20.

Mutations at beta N265 in γ-aminobutyric acid type A receptors alter both binding affinity and efficacy of potent anesthetics.

Stewart DS, Pierce DW, Hotta M, Stern AT, Forman SA.

PLoS One. 2014 Oct 27;9(10):e111470. doi: 10.1371/journal.pone.0111470. eCollection 2014.

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