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Mahanine synergistically enhances cytotoxicity of 5-fluorouracil through ROS-mediated activation of PTEN and p53/p73 in colon carcinoma.

Das R, Bhattacharya K, Sarkar S, Samanta SK, Pal BC, Mandal C.

Apoptosis. 2014 Jan;19(1):149-64. doi: 10.1007/s10495-013-0907-6.


β-Cryptoxanthin Synergistically Enhances the Antitumoral Activity of Oxaliplatin through ΔNP73 Negative Regulation in Colon Cancer.

San Millán C, Soldevilla B, Martín P, Gil-Calderón B, Compte M, Pérez-Sacristán B, Donoso E, Peña C, Romero J, Granado-Lorencio F, Bonilla F, Domínguez G.

Clin Cancer Res. 2015 Oct 1;21(19):4398-409. doi: 10.1158/1078-0432.CCR-14-2027.


Gypenosides Synergistically Enhances the Anti-Tumor Effect of 5-Fluorouracil on Colorectal Cancer In Vitro and In Vivo: A Role for Oxidative Stress-Mediated DNA Damage and p53 Activation.

Kong L, Wang X, Zhang K, Yuan W, Yang Q, Fan J, Wang P, Liu Q.

PLoS One. 2015 Sep 14;10(9):e0137888. doi: 10.1371/journal.pone.0137888.


Securinine induces p73-dependent apoptosis preferentially in p53-deficient colon cancer cells.

Rana S, Gupta K, Gomez J, Matsuyama S, Chakrabarti A, Agarwal ML, Agarwal A, Agarwal MK, Wald DN.

FASEB J. 2010 Jun;24(6):2126-34. doi: 10.1096/fj.09-148999.


Teng-Long-Bu-Zhong-Tang, a Chinese herbal formula, enhances anticancer effects of 5--Fluorouracil in CT26 colon carcinoma.

Deng S, Hu B, An HM, Du Q, Xu L, Shen KP, Shi XF, Wei MM, Wu Y.

BMC Complement Altern Med. 2013 Jun 8;13:128. doi: 10.1186/1472-6882-13-128.


Resistance of mitochondrial p53 to dominant inhibition.

Heyne K, Schmitt K, Mueller D, Armbruester V, Mestres P, Roemer K.

Mol Cancer. 2008 Jun 12;7:54. doi: 10.1186/1476-4598-7-54.


Mdm2 inhibition induces apoptosis in p53 deficient human colon cancer cells by activating p73- and E2F1-mediated expression of PUMA and Siva-1.

Ray RM, Bhattacharya S, Johnson LR.

Apoptosis. 2011 Jan;16(1):35-44. doi: 10.1007/s10495-010-0538-0.


JNK-NQO1 axis drives TAp73-mediated tumor suppression upon oxidative and proteasomal stress.

Kostecka A, Sznarkowska A, Meller K, Acedo P, Shi Y, Mohammad Sakil HA, Kawiak A, Lion M, Królicka A, Wilhelm M, Inga A, Zawacka-Pankau J.

Cell Death Dis. 2014 Oct 23;5:e1484. doi: 10.1038/cddis.2014.408.


Essential role of caspase-8 in p53/p73-dependent apoptosis induced by etoposide in head and neck carcinoma cells.

Liu J, Uematsu H, Tsuchida N, Ikeda MA.

Mol Cancer. 2011 Jul 31;10:95. doi: 10.1186/1476-4598-10-95.


Aronia melanocarpa juice induces a redox-sensitive p73-related caspase 3-dependent apoptosis in human leukemia cells.

Sharif T, Alhosin M, Auger C, Minker C, Kim JH, Etienne-Selloum N, Bories P, Gronemeyer H, Lobstein A, Bronner C, Fuhrmann G, Schini-Kerth VB.

PLoS One. 2012;7(3):e32526. doi: 10.1371/journal.pone.0032526.


Effects of ΔNp73β on cisplatin treatment in colon cancer cells.

Lööf J, Pfeifer D, Ding Z, Sun XF, Zhang H.

Mol Carcinog. 2012 Aug;51(8):628-35. doi: 10.1002/mc.20835.


Resveratrol displays converse dose-related effects on 5-fluorouracil-evoked colon cancer cell apoptosis: the roles of caspase-6 and p53.

Chan JY, Phoo MS, Clement MV, Pervaiz S, Lee SC.

Cancer Biol Ther. 2008 Aug;7(8):1305-12.


Nutlin-3 overcomes arsenic trioxide resistance and tumor metastasis mediated by mutant p53 in Hepatocellular Carcinoma.

Zheng T, Yin D, Lu Z, Wang J, Li Y, Chen X, Liang Y, Song X, Qi S, Sun B, Xie C, Meng X, Pan S, Liu J, Jiang H, Liu L.

Mol Cancer. 2014 May 31;13:133. doi: 10.1186/1476-4598-13-133.


GRAMD4 mimics p53 and mediates the apoptotic function of p73 at mitochondria.

John K, Alla V, Meier C, Pützer BM.

Cell Death Differ. 2011 May;18(5):874-86. doi: 10.1038/cdd.2010.153. Erratum in: Cell Death Differ. 2012 Mar;19(3):552.

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