Format
Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 76

1.

Analytical pharmacology and allosterism: the importance of quantifying drug parameters in drug discovery.

Kenakin T.

Drug Discov Today Technol. 2013 Summer;10(2):e229-35. doi: 10.1016/j.ddtec.2012.07.006. Review.

PMID:
24050273
2.

Quantifying biological activity in chemical terms: a pharmacology primer to describe drug effect.

Kenakin T.

ACS Chem Biol. 2009 Apr 17;4(4):249-60. doi: 10.1021/cb800299s. Epub 2009 Feb 4.

PMID:
19193052
3.

When simple agonism is not enough: emerging modalities of GPCR ligands.

Smith NJ, Bennett KA, Milligan G.

Mol Cell Endocrinol. 2011 Jan 15;331(2):241-7. doi: 10.1016/j.mce.2010.07.009. Epub 2010 Jul 21. Review.

PMID:
20654693
4.

Quantitative analysis of receptor allosterism and its implication for drug discovery.

Zhang R, Kavana M.

Expert Opin Drug Discov. 2015 Jul;10(7):763-80. doi: 10.1517/17460441.2015.1041498. Epub 2015 Apr 30. Review.

PMID:
25927503
5.

Allosteric modulation of G protein-coupled receptors: a pharmacological perspective.

Keov P, Sexton PM, Christopoulos A.

Neuropharmacology. 2011 Jan;60(1):24-35. doi: 10.1016/j.neuropharm.2010.07.010. Epub 2010 Jul 15. Review.

PMID:
20637785
6.

Mechanistic analysis of the function of agonists and allosteric modulators: reconciling two-state and operational models.

Roche D, Gil D, Giraldo J.

Br J Pharmacol. 2013 Jul;169(6):1189-202. doi: 10.1111/bph.12231. Review.

7.

Allosteric agonist modulators.

Kenakin T.

J Recept Signal Transduct Res. 2007;27(4):247-59.

PMID:
17885921
8.

Ligand detection in the allosteric world.

Kenakin TP.

J Biomol Screen. 2010 Feb;15(2):119-30. doi: 10.1177/1087057109357789. Epub 2010 Jan 19. Review.

PMID:
20086210
9.

Allosteric enhancers, allosteric agonists and ago-allosteric modulators: where do they bind and how do they act?

Schwartz TW, Holst B.

Trends Pharmacol Sci. 2007 Aug;28(8):366-73. Epub 2007 Jul 13. Review.

PMID:
17629958
10.

Allosterism and cannabinoid CB(1) receptors: the shape of things to come.

Ross RA.

Trends Pharmacol Sci. 2007 Nov;28(11):567-72. Review.

PMID:
18029031
11.

Data-driven analysis in drug discovery.

Kenakin T.

J Recept Signal Transduct Res. 2006;26(4):299-327.

PMID:
16818378
12.

Emerging paradigms in GPCR allostery: implications for drug discovery.

Wootten D, Christopoulos A, Sexton PM.

Nat Rev Drug Discov. 2013 Aug;12(8):630-44. doi: 10.1038/nrd4052. Review.

PMID:
23903222
13.

'7TM receptor allostery: putting numbers to shapeshifting proteins.

Kenakin TP.

Trends Pharmacol Sci. 2009 Sep;30(9):460-9. doi: 10.1016/j.tips.2009.06.007. Epub 2009 Sep 2. Review.

PMID:
19729207
14.

Allosteric GPCR modulators: taking advantage of permissive receptor pharmacology.

Leach K, Sexton PM, Christopoulos A.

Trends Pharmacol Sci. 2007 Aug;28(8):382-9. Epub 2007 Jul 13. Review.

PMID:
17629965
15.

G-protein coupled receptors as allosteric machines.

Kenakin T.

Receptors Channels. 2004;10(2):51-60. Review.

PMID:
15204035
16.

Allosteric agonists of 7TM receptors: expanding the pharmacological toolbox.

Langmead CJ, Christopoulos A.

Trends Pharmacol Sci. 2006 Sep;27(9):475-81. Epub 2006 Aug 4. Review.

PMID:
16889837
17.

G protein-coupled receptor allosterism and complexing.

Christopoulos A, Kenakin T.

Pharmacol Rev. 2002 Jun;54(2):323-74. Review.

PMID:
12037145
18.

Analytical pharmacology: the impact of numbers on pharmacology.

Kenakin T, Christopoulos A.

Trends Pharmacol Sci. 2011 Apr;32(4):189-96. doi: 10.1016/j.tips.2011.01.002. Epub 2011 Mar 10.

PMID:
21397341
19.

Allosteric properties of G protein-coupled receptor oligomers.

Springael JY, Urizar E, Costagliola S, Vassart G, Parmentier M.

Pharmacol Ther. 2007 Sep;115(3):410-8. Epub 2007 Jun 27. Review.

PMID:
17655934
20.

The impact of orthosteric radioligand depletion on the quantification of allosteric modulator interactions.

Avlani VA, McLoughlin DJ, Sexton PM, Christopoulos A.

J Pharmacol Exp Ther. 2008 Jun;325(3):927-34. doi: 10.1124/jpet.108.136978. Epub 2008 Mar 5.

PMID:
18322151

Supplemental Content

Support Center