Format
Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 114

1.

Pharmacophore-based discovery of new human dihydroorotate dehydrogenase inhibitor.

Lu P, Wang Y, Ma B, She J, Zhang Q, He M, Liu Y.

Med Chem. 2014 Jun;10(4):402-8.

PMID:
24047257
3.

Potent BACE-1 inhibitor design using pharmacophore modeling, in silico screening and molecular docking studies.

John S, Thangapandian S, Sakkiah S, Lee KW.

BMC Bioinformatics. 2011 Feb 15;12 Suppl 1:S28. doi: 10.1186/1471-2105-12-S1-S28.

4.

Design, synthesis, X-ray crystallographic analysis, and biological evaluation of thiazole derivatives as potent and selective inhibitors of human dihydroorotate dehydrogenase.

Zhu J, Han L, Diao Y, Ren X, Xu M, Xu L, Li S, Li Q, Dong D, Huang J, Liu X, Zhao Z, Wang R, Zhu L, Xu Y, Qian X, Li H.

J Med Chem. 2015 Feb 12;58(3):1123-39. doi: 10.1021/jm501127s. Epub 2015 Jan 26.

PMID:
25580811
5.

3D-QSAR Based Pharmacophore Modeling and Virtual Screening for Identification of Novel G Protein-Coupled Receptor40 Agonists.

Lu P, Wang Y, Ouyang P, She J, He M.

Curr Comput Aided Drug Des. 2015;11(1):51-6.

PMID:
26022066
6.

Design, synthesis and pharmacological evaluation of novel substituted quinoline-2-carboxamide derivatives as human dihydroorotate dehydrogenase (hDHODH) inhibitors and anticancer agents.

Vyas VK, Variya B, Ghate MD.

Eur J Med Chem. 2014 Jul 23;82:385-93. doi: 10.1016/j.ejmech.2014.05.064. Epub 2014 May 27.

PMID:
24929289
7.

E-pharmacophore and molecular dynamics study of flavonols and dihydroflavonols as inhibitors against dihydroorotate dehydrogenase.

Swaminathan P, Kalva S, Saleena LM.

Comb Chem High Throughput Screen. 2014;17(8):663-73.

PMID:
24655039
8.

Factors influencing the specificity of inhibitor binding to the human and malaria parasite dihydroorotate dehydrogenases.

Bedingfield PT, Cowen D, Acklam P, Cunningham F, Parsons MR, McConkey GA, Fishwick CW, Johnson AP.

J Med Chem. 2012 Jun 28;55(12):5841-50. doi: 10.1021/jm300157n. Epub 2012 Jun 15.

PMID:
22621375
9.

Novel insights for dihydroorotate dehydrogenase class 1A inhibitors discovery.

Cheleski J, Rocha JR, Pinheiro MP, Wiggers HJ, da Silva AB, Nonato MC, Montanari CA.

Eur J Med Chem. 2010 Dec;45(12):5899-909. doi: 10.1016/j.ejmech.2010.09.055. Epub 2010 Oct 7.

PMID:
20965617
10.

Identification of New Human Malaria Parasite Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors by Pharmacophore and Structure-Based Virtual Screening.

Pavadai E, El Mazouni F, Wittlin S, de Kock C, Phillips MA, Chibale K.

J Chem Inf Model. 2016 Mar 28;56(3):548-62. doi: 10.1021/acs.jcim.5b00680. Epub 2016 Mar 8.

11.

Synthesis of beta-hydroxy-propenamide derivatives and the inhibition of human dihydroorotate dehydrogenase.

Kim TH, Na HS, Löffler M.

Arch Pharm Res. 2003 Mar;26(3):197-201.

PMID:
12723931
12.

A three-dimensional pharmacophore model for IMPDH inhibitors.

Yang N, Wang J, Li J, Wang QH, Wang Y, Cheng MS.

Chem Biol Drug Des. 2011 Jul;78(1):175-82. doi: 10.1111/j.1747-0285.2011.01128.x. Epub 2011 May 31.

PMID:
21507206
13.

Novel selective and potent inhibitors of malaria parasite dihydroorotate dehydrogenase: discovery and optimization of dihydrothiophenone derivatives.

Xu M, Zhu J, Diao Y, Zhou H, Ren X, Sun D, Huang J, Han D, Zhao Z, Zhu L, Xu Y, Li H.

J Med Chem. 2013 Oct 24;56(20):7911-24. doi: 10.1021/jm400938g. Epub 2013 Oct 11.

PMID:
24073986
15.

Novel Diketopiperazine Dihydroorotate Dehydrogenase Inhibitors Purified from Traditional Tibetan Animal Medicine Osteon Myospalacem Baileyi.

Jiang L, Wen H, Shao Y, Yu R, Liu Z, Wang S, Wang Q, Zhao X, Zhang P, Tao Y, Mei L.

Chem Biol Drug Des. 2015 Oct;86(4):626-36. doi: 10.1111/cbdd.12530. Epub 2015 Mar 1.

PMID:
25626527
16.

Chemometric modeling, docking and in silico design of triazolopyrimidine-based dihydroorotate dehydrogenase inhibitors as antimalarials.

Ojha PK, Roy K.

Eur J Med Chem. 2010 Oct;45(10):4645-56. doi: 10.1016/j.ejmech.2010.07.034. Epub 2010 Jul 24.

PMID:
20708304
17.

3D QSAR pharmacophore modeling for c-Met kinase inhibitors.

Huang D, Zhu X, Tang C, Mei Y, Chen W, Yang B, Han J, Qian H, Huang W.

Med Chem. 2012 Nov;8(6):1117-25.

PMID:
22779800
18.

Structure of Plasmodium falciparum dihydroorotate dehydrogenase with a bound inhibitor.

Hurt DE, Widom J, Clardy J.

Acta Crystallogr D Biol Crystallogr. 2006 Mar;62(Pt 3):312-23. Epub 2006 Feb 22.

PMID:
16510978
20.

Comparative study between 3D-QSAR and Docking-Based Pharmacophore models for potent Plasomodium falciparum dihydroorotate dehydrogenase inhibitors.

Tseng TS, Lee YC, Hsiao NW, Liu YR, Tsai KC.

Bioorg Med Chem Lett. 2016 Jan 15;26(2):265-271. doi: 10.1016/j.bmcl.2015.12.043. Epub 2015 Dec 12.

PMID:
26707392

Supplemental Content

Support Center