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Items: 1 to 20 of 90

1.

Comparison of methods for image-based profiling of cellular morphological responses to small-molecule treatment.

Ljosa V, Caie PD, Ter Horst R, Sokolnicki KL, Jenkins EL, Daya S, Roberts ME, Jones TR, Singh S, Genovesio A, Clemons PA, Carragher NO, Carpenter AE.

J Biomol Screen. 2013 Dec;18(10):1321-9. doi: 10.1177/1087057113503553. Epub 2013 Sep 17.

2.

Highly multiplexed phenotypic imaging for cell proliferation studies.

Cappella P, Gasparri F.

J Biomol Screen. 2014 Jan;19(1):145-57. doi: 10.1177/1087057113495712. Epub 2013 Jul 29.

PMID:
23896684
3.

Image-based multivariate profiling of drug responses from single cells.

Loo LH, Wu LF, Altschuler SJ.

Nat Methods. 2007 May;4(5):445-53. Epub 2007 Apr 1.

PMID:
17401369
4.

A dataset of images and morphological profiles of 30,000 small-molecule treatments using the Cell Painting assay.

Bray MA, Gustafsdottir SM, Ljosa V, Singh S, Sokolnicki KL, Bittker JA, Bodycombe NE, Dancík V, Hasaka TP, Hon CS, Kemp MM, Li K, Walpita D, Wawer MJ, Golub TR, Schreiber SL, Clemons PA, Shamji AF, Carpenter AE.

Gigascience. 2017 Jan 7. doi: 10.1093/gigascience/giw014. [Epub ahead of print]

PMID:
28327978
5.

The Power of Sophisticated Phenotypic Screening and Modern Mechanism-of-Action Methods.

Wagner BK, Schreiber SL.

Cell Chem Biol. 2016 Jan 21;23(1):3-9. doi: 10.1016/j.chembiol.2015.11.008. Review.

6.

Small-molecule screening and profiling by using automated microscopy.

Mitchison TJ.

Chembiochem. 2005 Jan;6(1):33-9. Review.

PMID:
15568196
7.

"Function-first" lead discovery: mode of action profiling of natural product libraries using image-based screening.

Schulze CJ, Bray WM, Woerhmann MH, Stuart J, Lokey RS, Linington RG.

Chem Biol. 2013 Feb 21;20(2):285-95. doi: 10.1016/j.chembiol.2012.12.007.

8.

Cell-based high-content screening of small-molecule libraries.

Korn K, Krausz E.

Curr Opin Chem Biol. 2007 Oct;11(5):503-10. Epub 2007 Oct 10. Review.

PMID:
17931958
9.

Mechanism of action-based classification of antibiotics using high-content bacterial image analysis.

Peach KC, Bray WM, Winslow D, Linington PF, Linington RG.

Mol Biosyst. 2013 Jul;9(7):1837-48. doi: 10.1039/c3mb70027e. Epub 2013 Apr 23.

10.

Identification of anti-tumour biologics using primary tumour models, 3-D phenotypic screening and image-based multi-parametric profiling.

Sandercock AM, Rust S, Guillard S, Sachsenmeier KF, Holoweckyj N, Hay C, Flynn M, Huang Q, Yan K, Herpers B, Price LS, Soden J, Freeth J, Jermutus L, Hollingsworth R, Minter R.

Mol Cancer. 2015 Jul 31;14:147. doi: 10.1186/s12943-015-0415-0.

11.

Large-scale cytological profiling for functional analysis of bioactive compounds.

Woehrmann MH, Bray WM, Durbin JK, Nisam SC, Michael AK, Glassey E, Stuart JM, Lokey RS.

Mol Biosyst. 2013 Nov;9(11):2604-17. doi: 10.1039/c3mb70245f.

PMID:
24056581
12.

Multidimensional drug profiling by automated microscopy.

Perlman ZE, Slack MD, Feng Y, Mitchison TJ, Wu LF, Altschuler SJ.

Science. 2004 Nov 12;306(5699):1194-8.

13.

Image analysis benchmarking methods for high-content screen design.

Fuller CJ, Straight AF.

J Microsc. 2010 May;238(2):145-61. doi: 10.1111/j.1365-2818.2009.03337.x.

14.

High-content analysis in preclinical drug discovery.

Denner P, Schmalowsky J, Prechtl S.

Comb Chem High Throughput Screen. 2008 Mar;11(3):216-30. Review.

PMID:
18336214
15.

Toward performance-diverse small-molecule libraries for cell-based phenotypic screening using multiplexed high-dimensional profiling.

Wawer MJ, Li K, Gustafsdottir SM, Ljosa V, Bodycombe NE, Marton MA, Sokolnicki KL, Bray MA, Kemp MM, Winchester E, Taylor B, Grant GB, Hon CS, Duvall JR, Wilson JA, Bittker JA, Dančík V, Narayan R, Subramanian A, Winckler W, Golub TR, Carpenter AE, Shamji AF, Schreiber SL, Clemons PA.

Proc Natl Acad Sci U S A. 2014 Jul 29;111(30):10911-6. doi: 10.1073/pnas.1410933111. Epub 2014 Jul 14.

16.

Robust Classification of Small-Molecule Mechanism of Action Using a Minimalist High-Content Microscopy Screen and Multidimensional Phenotypic Trajectory Analysis.

Twarog NR, Low JA, Currier DG, Miller G, Chen T, Shelat AA.

PLoS One. 2016 Feb 17;11(2):e0149439. doi: 10.1371/journal.pone.0149439. eCollection 2016.

17.

Building predictive models for mechanism-of-action classification from phenotypic assay data sets.

Berg EL, Yang J, Polokoff MA.

J Biomol Screen. 2013 Dec;18(10):1260-9. doi: 10.1177/1087057113505324. Epub 2013 Oct 2.

PMID:
24088371
18.

Retrieving novel C5aR antagonists using a hybrid ligand-based virtual screening protocol based on SVM classification and pharmacophore models.

Qing XY, Zhang CH, Li LL, Ji P, Ma S, Wan HL, Wang ZR, Zou J, Yang SY.

J Biomol Struct Dyn. 2013;31(2):215-23. doi: 10.1080/07391102.2012.698245. Epub 2012 Jul 25.

PMID:
22831459
19.

High-content analysis of kinase activity in cells.

Gasparri F, Sola F, Bandiera T, Moll J, Galvani A.

Comb Chem High Throughput Screen. 2008 Aug;11(7):523-36. Review.

PMID:
18694389
20.

High content screening for compounds that induce early stages of human embryonic stem cell differentiation.

Jee J, Jeon H, Hwang D, Sommer P, Park Z, Cechetto J, Dorval T.

Comb Chem High Throughput Screen. 2012 Sep;15(8):656-65.

PMID:
22364550

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