Format
Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 103

1.

Arimetamycin A: improving clinically relevant families of natural products through sequence-guided screening of soil metagenomes.

Kang HS, Brady SF.

Angew Chem Int Ed Engl. 2013 Oct 11;52(42):11063-7. doi: 10.1002/anie.201305109. Epub 2013 Sep 3.

2.

Culture-independent discovery of natural products from soil metagenomes.

Katz M, Hover BM, Brady SF.

J Ind Microbiol Biotechnol. 2016 Mar;43(2-3):129-41. doi: 10.1007/s10295-015-1706-6. Epub 2015 Nov 19. Review.

PMID:
26586404
3.

The role of bioreductive activation of antitumour anthracycline drugs in cytotoxic activity against sensitive and multidrug resistant leukaemia HL60 cells.

Kostrzewa-Nowak D, Bieg B, Paine MJ, Wolf CR, Tarasiuk J.

Eur J Pharmacol. 2012 Jan 15;674(2-3):112-25. doi: 10.1016/j.ejphar.2011.10.047. Epub 2011 Nov 15.

PMID:
22115891
4.

Mining soil metagenomes to better understand the evolution of natural product structural diversity: pentangular polyphenols as a case study.

Kang HS, Brady SF.

J Am Chem Soc. 2014 Dec 31;136(52):18111-9. doi: 10.1021/ja510606j. Epub 2014 Dec 18.

5.

Aranciamycin analogs generated by combinatorial biosynthesis show improved antitumor activity.

Luzhetskyy A, Hoffmann J, Pelzer S, Wohlert SE, Vente A, Bechthold A.

Appl Microbiol Biotechnol. 2008 Aug;80(1):15-9. doi: 10.1007/s00253-008-1515-1. Epub 2008 Jun 13.

PMID:
18553079
6.

Mapping gene clusters within arrayed metagenomic libraries to expand the structural diversity of biomedically relevant natural products.

Owen JG, Reddy BV, Ternei MA, Charlop-Powers Z, Calle PY, Kim JH, Brady SF.

Proc Natl Acad Sci U S A. 2013 Jul 16;110(29):11797-802. doi: 10.1073/pnas.1222159110. Epub 2013 Jul 3.

7.

Synthesis and antitumor activity of cyclodepsipeptide zygosporamide and its analogues.

Wang Y, Zhang F, Zhang Y, Liu JO, Ma D.

Bioorg Med Chem Lett. 2008 Aug 1;18(15):4385-7. doi: 10.1016/j.bmcl.2008.06.066. Epub 2008 Jun 21.

PMID:
18606540
8.

Discovery of indolotryptoline antiproliferative agents by homology-guided metagenomic screening.

Chang FY, Brady SF.

Proc Natl Acad Sci U S A. 2013 Feb 12;110(7):2478-83. doi: 10.1073/pnas.1218073110. Epub 2013 Jan 9.

9.

Synthesis and SAR studies of marine natural products ma'edamines A, B and their analogues.

Saha S, Reddy ChV, Xu S, Sankar S, Neamati N, Patro B.

Bioorg Med Chem Lett. 2013 Sep 15;23(18):5135-9. doi: 10.1016/j.bmcl.2013.07.017. Epub 2013 Jul 19.

PMID:
23927972
10.

A new cyano-substituted anthracycline metabolite from Streptomyces sp. HS-NF-1006.

Wan X, Ren HJ, Du MN, Qi H, Zhang H, Chen AL, Wang JD.

J Antibiot (Tokyo). 2017 Feb;70(2):219-221. doi: 10.1038/ja.2016.112. Epub 2016 Sep 7. No abstract available.

PMID:
27599767
11.

Mycalol: a natural lipid with promising cytotoxic properties against human anaplastic thyroid carcinoma cells.

Cutignano A, Nuzzo G, D'Angelo D, Borbone E, Fusco A, Fontana A.

Angew Chem Int Ed Engl. 2013 Aug 26;52(35):9256-60. doi: 10.1002/anie.201303039. Epub 2013 Jul 15. No abstract available.

PMID:
23857783
12.

Arixanthomycins A-C: Phylogeny-guided discovery of biologically active eDNA-derived pentangular polyphenols.

Kang HS, Brady SF.

ACS Chem Biol. 2014 Jun 20;9(6):1267-72. doi: 10.1021/cb500141b. Epub 2014 Apr 30.

13.

Editorial: Discovery and biosynthesis of natural products with anti-cancer activities.

Deng H.

Anticancer Agents Med Chem. 2015;15(3):276. No abstract available.

PMID:
25801124
14.

N-methylation of anthracyclines modulates their cytotoxicity and pharmacokinetic in wild type and multidrug resistant cells.

Gate L, Couvreur P, Nguyen-Ba G, Tapiero H.

Biomed Pharmacother. 2003 Sep;57(7):301-8.

PMID:
14499178
15.

Multiplexed metagenome mining using short DNA sequence tags facilitates targeted discovery of epoxyketone proteasome inhibitors.

Owen JG, Charlop-Powers Z, Smith AG, Ternei MA, Calle PY, Reddy BV, Montiel D, Brady SF.

Proc Natl Acad Sci U S A. 2015 Apr 7;112(14):4221-6. doi: 10.1073/pnas.1501124112. Epub 2015 Mar 23.

16.

Urban park soil microbiomes are a rich reservoir of natural product biosynthetic diversity.

Charlop-Powers Z, Pregitzer CC, Lemetre C, Ternei MA, Maniko J, Hover BM, Calle PY, McGuire KL, Garbarino J, Forgione HM, Charlop-Powers S, Brady SF.

Proc Natl Acad Sci U S A. 2016 Dec 20;113(51):14811-14816. doi: 10.1073/pnas.1615581113. Epub 2016 Nov 28.

17.

Formation of squaric acid amides of anthracycline antibiotics. Synthesis and cytotoxic properties.

Tevyashova A, Sztaricskai F, Batta G, Herczegh P, Jeney A.

Bioorg Med Chem Lett. 2004 Sep 20;14(18):4783-9.

PMID:
15324908
18.

Chemistry and biology of bengamides and bengazoles, bioactive natural products from Jaspis sponges.

García-Ruiz C, Sarabia F.

Mar Drugs. 2014 Mar 18;12(3):1580-622. doi: 10.3390/md12031580. Review.

19.

Cytotoxic acyl amides from the soil fungus Gymnascella dankaliensis.

Hammerschmidt L, Aly AH, Abdel-Aziz M, Müller WE, Lin W, Daletos G, Proksch P.

Bioorg Med Chem. 2015 Feb 15;23(4):712-9. doi: 10.1016/j.bmc.2014.12.068. Epub 2015 Jan 3.

PMID:
25600409
20.

Novel natural-product-like caged xanthones with improved druglike properties and in vivo antitumor potency.

Wu Y, Hu M, Yang L, Li X, Bian J, Jiang F, Sun H, You Q, Zhang X.

Bioorg Med Chem Lett. 2015 Jun 15;25(12):2584-8. doi: 10.1016/j.bmcl.2015.04.031. Epub 2015 Apr 18.

PMID:
25958244

Supplemental Content

Support Center