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SIRT1 negatively regulates amyloid-beta-induced inflammation via the NF-κB pathway.

Cao L, Liu C, Wang F, Wang H.

Braz J Med Biol Res. 2013 Aug;46(8):659-69. doi: 10.1590/1414-431X20132903. Epub 2013 Aug 30.


Vinpocetine inhibits amyloid-beta induced activation of NF-κB, NLRP3 inflammasome and cytokine production in retinal pigment epithelial cells.

Liu RT, Wang A, To E, Gao J, Cao S, Cui JZ, Matsubara JA.

Exp Eye Res. 2014 Oct;127:49-58. doi: 10.1016/j.exer.2014.07.003. Epub 2014 Jul 17.


Aβ-induced senescent retinal pigment epithelial cells create a proinflammatory microenvironment in AMD.

Cao L, Wang H, Wang F, Xu D, Liu F, Liu C.

Invest Ophthalmol Vis Sci. 2013 May 1;54(5):3738-50. doi: 10.1167/iovs.13-11612.


Amyloid-β-induced matrix metalloproteinase-9 secretion is associated with retinal pigment epithelial barrier disruption.

Cao L, Wang H, Wang F.

Int J Mol Med. 2013 May;31(5):1105-12. doi: 10.3892/ijmm.2013.1310. Epub 2013 Mar 20.


Inhibition of BET bromodomains alleviates inflammation in human RPE cells.

Hytti M, Tokarz P, Määttä E, Piippo N, Korhonen E, Suuronen T, Honkakoski P, Kaarniranta K, Lahtela-Kakkonen M, Kauppinen A.

Biochem Pharmacol. 2016 Jun 15;110-111:71-9. doi: 10.1016/j.bcp.2016.04.009. Epub 2016 Apr 19.


Activation of Sirt1 by resveratrol inhibits TNF-α induced inflammation in fibroblasts.

Zhu X, Liu Q, Wang M, Liang M, Yang X, Xu X, Zou H, Qiu J.

PLoS One. 2011;6(11):e27081. doi: 10.1371/journal.pone.0027081. Epub 2011 Nov 1.


IL-33 is induced by amyloid-β stimulation and regulates inflammatory cytokine production in retinal pigment epithelium cells.

Liu XC, Liu XF, Jian CX, Li CJ, He SZ.

Inflammation. 2012 Apr;35(2):776-84. doi: 10.1007/s10753-011-9379-4.


Leptin attenuates BACE1 expression and amyloid-β genesis via the activation of SIRT1 signaling pathway.

Marwarha G, Raza S, Meiers C, Ghribi O.

Biochim Biophys Acta. 2014 Sep;1842(9):1587-95. doi: 10.1016/j.bbadis.2014.05.015. Epub 2014 May 27.


Sirtuin-1 (SIRT1) is required for promoting chondrogenic differentiation of mesenchymal stem cells.

Buhrmann C, Busch F, Shayan P, Shakibaei M.

J Biol Chem. 2014 Aug 8;289(32):22048-62. doi: 10.1074/jbc.M114.568790. Epub 2014 Jun 24.


SIRT1, a class III histone deacetylase, regulates TNF-α-induced inflammation in human chondrocytes.

Moon MH, Jeong JK, Lee YJ, Seol JW, Jackson CJ, Park SY.

Osteoarthritis Cartilage. 2013 Mar;21(3):470-80. doi: 10.1016/j.joca.2012.11.017. Epub 2012 Dec 19.


Fullerenol protects retinal pigment epithelial cells from oxidative stress-induced premature senescence via activating SIRT1.

Zhuge CC, Xu JY, Zhang J, Li W, Li P, Li Z, Chen L, Liu X, Shang P, Xu H, Lu Y, Wang F, Lu L, Xu GT.

Invest Ophthalmol Vis Sci. 2014 May 20;55(7):4628-38. doi: 10.1167/iovs.13-13732.


SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling.

Chen J, Zhou Y, Mueller-Steiner S, Chen LF, Kwon H, Yi S, Mucke L, Gan L.

J Biol Chem. 2005 Dec 2;280(48):40364-74. Epub 2005 Sep 23.


Age-related increases in amyloid beta and membrane attack complex: evidence of inflammasome activation in the rodent eye.

Zhao T, Gao J, Van J, To E, Wang A, Cao S, Cui JZ, Guo JP, Lee M, McGeer PL, Matsubara JA.

J Neuroinflammation. 2015 Jun 24;12:121. doi: 10.1186/s12974-015-0337-1.


Amyloid β induces NLRP3 inflammasome activation in retinal pigment epithelial cells via NADPH oxidase- and mitochondria-dependent ROS production.

Wang K, Yao Y, Zhu X, Zhang K, Zhou F, Zhu L.

J Biochem Mol Toxicol. 2017 Jun;31(6). doi: 10.1002/jbt.21887. Epub 2016 Dec 22.


SIRT1-PGC1α-NFκB Pathway of Oxidative and Inflammatory Stress during Trypanosoma cruzi Infection: Benefits of SIRT1-Targeted Therapy in Improving Heart Function in Chagas Disease.

Wan X, Wen JJ, Koo SJ, Liang LY, Garg NJ.

PLoS Pathog. 2016 Oct 20;12(10):e1005954. doi: 10.1371/journal.ppat.1005954. eCollection 2016 Oct.


Detecting Aβ deposition and RPE cell senescence in the retinas of SAMP8 mice.

Feng L, Cao L, Zhang Y, Wang F.

Discov Med. 2016 Mar;21(115):149-58.


SIRT1 Inhibits the Catabolic Effect of IL-1β Through TLR2/SIRT1/NF-κB Pathway in Human Degenerative Nucleus Pulposus Cells.

Shen J, Fang J, Hao J, Zhong X, Wang D, Ren H, Hu Z.

Pain Physician. 2016 Jan;19(1):E215-26.


Antagonistic crosstalk between NF-κB and SIRT1 in the regulation of inflammation and metabolic disorders.

Kauppinen A, Suuronen T, Ojala J, Kaarniranta K, Salminen A.

Cell Signal. 2013 Oct;25(10):1939-48. doi: 10.1016/j.cellsig.2013.06.007. Epub 2013 Jun 11. Review.


MiR-21 Regulates TNF-α-Induced CD40 Expression via the SIRT1-NF-κB Pathway in Renal Inner Medullary Collecting Duct Cells.

Lin Q, Geng Y, Zhao M, Lin S, Zhu Q, Tian Z.

Cell Physiol Biochem. 2017;41(1):124-136. doi: 10.1159/000455981. Epub 2017 Jan 18.


α-Iso-cubebenol inhibits inflammation-mediated neurotoxicity and amyloid beta 1-42 fibril-induced microglial activation.

Park SY, Park TG, Lee SJ, Bae YS, Ko MJ, Choi YW.

J Pharm Pharmacol. 2014 Jan;66(1):93-105. doi: 10.1111/jphp.12160. Epub 2013 Oct 21.


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