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Items: 1 to 20 of 92

1.

Mitochondrial G protein coupled receptor kinase 2 regulates proinflammatory responses in macrophages.

Sorriento D, Fusco A, Ciccarelli M, Rungi A, Anastasio A, Carillo A, Dorn GW 2nd, Trimarco B, Iaccarino G.

FEBS Lett. 2013 Nov 1;587(21):3487-94. doi: 10.1016/j.febslet.2013.09.002.

2.

Endothelial G protein-coupled receptor kinase 2 regulates vascular homeostasis through the control of free radical oxygen species.

Ciccarelli M, Sorriento D, Franco A, Fusco A, Del Giudice C, Annunziata R, Cipolletta E, Monti MG, Dorn GW 2nd, Trimarco B, Iaccarino G.

Arterioscler Thromb Vasc Biol. 2013 Oct;33(10):2415-24. doi: 10.1161/ATVBAHA.113.302262.

3.

G-protein-coupled-receptor kinases mediate TNFα-induced NFκB signalling via direct interaction with and phosphorylation of IκBα.

Patial S, Luo J, Porter KJ, Benovic JL, Parameswaran N.

Biochem J. 2009 Dec 14;425(1):169-78. doi: 10.1042/BJ20090908.

4.

Prodeath signaling of G protein-coupled receptor kinase 2 in cardiac myocytes after ischemic stress occurs via extracellular signal-regulated kinase-dependent heat shock protein 90-mediated mitochondrial targeting.

Chen M, Sato PY, Chuprun JK, Peroutka RJ, Otis NJ, Ibetti J, Pan S, Sheu SS, Gao E, Koch WJ.

Circ Res. 2013 Apr 12;112(8):1121-34. doi: 10.1161/CIRCRESAHA.112.300754.

5.

Gβγ-independent recruitment of G-protein coupled receptor kinase 2 drives tumor necrosis factor α-induced cardiac β-adrenergic receptor dysfunction.

Vasudevan NT, Mohan ML, Gupta MK, Martelli EE, Hussain AK, Qin Y, Chandrasekharan UM, Young D, Feldman AM, Sen S, Dorn GW 2nd, Dicorleto PE, Naga Prasad SV.

Circulation. 2013 Jul 23;128(4):377-87. doi: 10.1161/CIRCULATIONAHA.113.003183.

6.

Myeloid-specific GPCR kinase-2 negatively regulates NF-κB1p105-ERK pathway and limits endotoxemic shock in mice.

Patial S, Saini Y, Parvataneni S, Appledorn DM, Dorn GW 2nd, Lapres JJ, Amalfitano A, Senagore P, Parameswaran N.

J Cell Physiol. 2011 Mar;226(3):627-37. doi: 10.1002/jcp.22384.

7.

Mitochondrial localization unveils a novel role for GRK2 in organelle biogenesis.

Fusco A, Santulli G, Sorriento D, Cipolletta E, Garbi C, Dorn GW 2nd, Trimarco B, Feliciello A, Iaccarino G.

Cell Signal. 2012 Feb;24(2):468-75. doi: 10.1016/j.cellsig.2011.09.026.

8.

GRK2 compromises cardiomyocyte mitochondrial function by diminishing fatty acid-mediated oxygen consumption and increasing superoxide levels.

Sato PY, Chuprun JK, Ibetti J, Cannavo A, Drosatos K, Elrod JW, Koch WJ.

J Mol Cell Cardiol. 2015 Dec;89(Pt B):360-4. doi: 10.1016/j.yjmcc.2015.10.002.

9.

Microglial/macrophage GRK2 determines duration of peripheral IL-1beta-induced hyperalgesia: contribution of spinal cord CX3CR1, p38 and IL-1 signaling.

Willemen HL, Eijkelkamp N, Wang H, Dantzer R, Dorn GW 2nd, Kelley KW, Heijnen CJ, Kavelaars A.

Pain. 2010 Sep;150(3):550-60. doi: 10.1016/j.pain.2010.06.015.

10.

Integrating GRK2 and NFkappaB in the Pathophysiology of Cardiac Hypertrophy.

Sorriento D, Santulli G, Franco A, Cipolletta E, Napolitano L, Gambardella J, Gomez-Monterrey I, Campiglia P, Trimarco B, Iaccarino G, Ciccarelli M.

J Cardiovasc Transl Res. 2015 Nov;8(8):493-502. doi: 10.1007/s12265-015-9646-0.

PMID:
26224342
12.

GRK2-dependent desensitization downstream of G proteins.

Jurado-Pueyo M, Campos PM, Mayor F, Murga C.

J Recept Signal Transduct Res. 2008;28(1-2):59-70. doi: 10.1080/10799890801941939 . Review.

PMID:
18437630
13.

Mitochondria contribute to LPS-induced MAPK activation via uncoupling protein UCP2 in macrophages.

Emre Y, Hurtaud C, Nübel T, Criscuolo F, Ricquier D, Cassard-Doulcier AM.

Biochem J. 2007 Mar 1;402(2):271-8.

14.

Inhibition of WNT signaling by G protein-coupled receptor (GPCR) kinase 2 (GRK2).

Wang L, Gesty-Palmer D, Fields TA, Spurney RF.

Mol Endocrinol. 2009 Sep;23(9):1455-65. doi: 10.1210/me.2009-0084.

15.

TLR4 Signaling augments monocyte chemotaxis by regulating G protein-coupled receptor kinase 2 translocation.

Liu Z, Jiang Y, Li Y, Wang J, Fan L, Scott MJ, Xiao G, Li S, Billiar TR, Wilson MA, Fan J.

J Immunol. 2013 Jul 15;191(2):857-64. doi: 10.4049/jimmunol.1300790. Erratum in: J Immunol. 2013 Sep 1;191(5):2847.

16.

G alpha(q)-mediated activation of GRK2 by mechanical stretch in cardiac myocytes: the role of protein kinase C.

Malhotra R, D'Souza KM, Staron ML, Birukov KG, Bodi I, Akhter SA.

J Biol Chem. 2010 Apr 30;285(18):13748-60. doi: 10.1074/jbc.M110.109272. Retraction in: Malhotra R, D'Souza KM, Staron ML, Birukov KG, Bodi I, Akhter SA. J Biol Chem. 2016 Jul 1;291(27):14390.

17.

Roles of phosphorylation-dependent and -independent mechanisms in the regulation of histamine H2 receptor by G protein-coupled receptor kinase 2.

Fernandez N, Gottardo FL, Alonso MN, Monczor F, Shayo C, Davio C.

J Biol Chem. 2011 Aug 19;286(33):28697-706. doi: 10.1074/jbc.M111.269613.

18.

Regulation of the epithelial Na+ channel by the RH domain of G protein-coupled receptor kinase, GRK2, and Galphaq/11.

Lee IH, Song SH, Campbell CR, Kumar S, Cook DI, Dinudom A.

J Biol Chem. 2011 Jun 3;286(22):19259-69. doi: 10.1074/jbc.M111.239772.

19.

Mitochondrial ROS govern the LPS-induced pro-inflammatory response in microglia cells by regulating MAPK and NF-κB pathways.

Park J, Min JS, Kim B, Chae UB, Yun JW, Choi MS, Kong IK, Chang KT, Lee DS.

Neurosci Lett. 2015 Jan 1;584:191-6. doi: 10.1016/j.neulet.2014.10.016.

PMID:
25459294
20.

Low nociceptor GRK2 prolongs prostaglandin E2 hyperalgesia via biased cAMP signaling to Epac/Rap1, protein kinase Cepsilon, and MEK/ERK.

Eijkelkamp N, Wang H, Garza-Carbajal A, Willemen HL, Zwartkruis FJ, Wood JN, Dantzer R, Kelley KW, Heijnen CJ, Kavelaars A.

J Neurosci. 2010 Sep 22;30(38):12806-15. doi: 10.1523/JNEUROSCI.3142-10.2010.

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