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1.55Å-resolution structure of ent-copalyl diphosphate synthase and exploration of general acid function by site-directed mutagenesis.

Köksal M, Potter K, Peters RJ, Christianson DW.

Biochim Biophys Acta. 2014 Jan;1840(1):184-90. doi: 10.1016/j.bbagen.2013.09.004. Epub 2013 Sep 12.


Structure and mechanism of the diterpene cyclase ent-copalyl diphosphate synthase.

Köksal M, Hu H, Coates RM, Peters RJ, Christianson DW.

Nat Chem Biol. 2011 May 22;7(7):431-3. doi: 10.1038/nchembio.578.


Structure, function and inhibition of ent-kaurene synthase from Bradyrhizobium japonicum.

Liu W, Feng X, Zheng Y, Huang CH, Nakano C, Hoshino T, Bogue S, Ko TP, Chen CC, Cui Y, Li J, Wang I, Hsu ST, Oldfield E, Guo RT.

Sci Rep. 2014 Oct 1;4:6214. doi: 10.1038/srep06214.


Two residues determine the product profile of the class II diterpene synthases TPS14 and TPS21 of Tripterygium wilfordii.

Hansen NL, Nissen JN, Hamberger B.

Phytochemistry. 2017 Jun;138:52-56. doi: 10.1016/j.phytochem.2017.02.022. Epub 2017 Mar 6.


X-ray crystal structure of aristolochene synthase from Aspergillus terreus and evolution of templates for the cyclization of farnesyl diphosphate.

Shishova EY, Di Costanzo L, Cane DE, Christianson DW.

Biochemistry. 2007 Feb 20;46(7):1941-51. Epub 2007 Jan 30.


Mechanism of Germacradien-4-ol Synthase-Controlled Water Capture.

Grundy DJ, Chen M, González V, Leoni S, Miller DJ, Christianson DW, Allemann RK.

Biochemistry. 2016 Apr 12;55(14):2112-21. doi: 10.1021/acs.biochem.6b00115. Epub 2016 Mar 30.


Novel product chemistry from mechanistic analysis of ent-copalyl diphosphate synthases from plant hormone biosynthesis.

Potter K, Criswell J, Zi J, Stubbs A, Peters RJ.

Angew Chem Int Ed Engl. 2014 Jul 7;53(28):7198-202. doi: 10.1002/anie.201402911. Epub 2014 May 23.


One amino acid makes the difference: the formation of ent-kaurene and 16α-hydroxy-ent-kaurane by diterpene synthases in poplar.

Irmisch S, Müller AT, Schmidt L, Günther J, Gershenzon J, Köllner TG.

BMC Plant Biol. 2015 Oct 28;15:262. doi: 10.1186/s12870-015-0647-6.


Biosynthesis of the microtubule-destabilizing diterpene pseudolaric acid B from golden larch involves an unusual diterpene synthase.

Mafu S, Karunanithi PS, Palazzo TA, Harrod BL, Rodriguez SM, Mollhoff IN, O'Brien TE, Tong S, Fiehn O, Tantillo DJ, Bohlmann J, Zerbe P.

Proc Natl Acad Sci U S A. 2017 Jan 31;114(5):974-979. doi: 10.1073/pnas.1612901114. Epub 2017 Jan 17.


Transcripts of two ent-copalyl diphosphate synthase genes differentially localize in rice plants according to their distinct biological roles.

Toyomasu T, Usui M, Sugawara C, Kanno Y, Sakai A, Takahashi H, Nakazono M, Kuroda M, Miyamoto K, Morimoto Y, Mitsuhashi W, Okada K, Yamaguchi S, Yamane H.

J Exp Bot. 2015 Jan;66(1):369-76. doi: 10.1093/jxb/eru424. Epub 2014 Oct 21.


Cocrystal structure of protein farnesyltransferase complexed with a farnesyl diphosphate substrate.

Long SB, Casey PJ, Beese LS.

Biochemistry. 1998 Jul 7;37(27):9612-8.


Biological functions of ent- and syn-copalyl diphosphate synthases in rice: key enzymes for the branch point of gibberellin and phytoalexin biosynthesis.

Otomo K, Kenmoku H, Oikawa H, König WA, Toshima H, Mitsuhashi W, Yamane H, Sassa T, Toyomasu T.

Plant J. 2004 Sep;39(6):886-93.


Diterpene cyclases and the nature of the isoprene fold.

Cao R, Zhang Y, Mann FM, Huang C, Mukkamala D, Hudock MP, Mead ME, Prisic S, Wang K, Lin FY, Chang TK, Peters RJ, Oldfield E.

Proteins. 2010 Aug 15;78(11):2417-32. doi: 10.1002/prot.22751.


Roles of amino acids in the Escherichia coli octaprenyl diphosphate synthase active site probed by structure-guided site-directed mutagenesis.

Chang KM, Chen SH, Kuo CJ, Chang CK, Guo RT, Yang JM, Liang PH.

Biochemistry. 2012 Apr 24;51(16):3412-9. doi: 10.1021/bi300069j. Epub 2012 Apr 10.


16-Aza-ent-beyerane and 16-Aza-ent-trachylobane: potent mechanism-based inhibitors of recombinant ent-kaurene synthase from Arabidopsis thaliana.

Roy A, Roberts FG, Wilderman PR, Zhou K, Peters RJ, Coates RM.

J Am Chem Soc. 2007 Oct 17;129(41):12453-60. Epub 2007 Sep 25.

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