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Role of Shp2 in forebrain neurons in regulating metabolic and cardiovascular functions and responses to leptin.

do Carmo JM, da Silva AA, Sessums PO, Ebaady SH, Pace BR, Rushing JS, Davis MT, Hall JE.

Int J Obes (Lond). 2014 Jun;38(6):775-83. doi: 10.1038/ijo.2013.177. Epub 2013 Sep 13.


Shp2 signaling in POMC neurons is important for leptin's actions on blood pressure, energy balance, and glucose regulation.

do Carmo JM, da Silva AA, Ebaady SE, Sessums PO, Abraham RS, Elmquist JK, Lowell BB, Hall JE.

Am J Physiol Regul Integr Comp Physiol. 2014 Dec 15;307(12):R1438-47. doi: 10.1152/ajpregu.00131.2014. Epub 2014 Oct 22.


Control of blood pressure, appetite, and glucose by leptin in mice lacking leptin receptors in proopiomelanocortin neurons.

do Carmo JM, da Silva AA, Cai Z, Lin S, Dubinion JH, Hall JE.

Hypertension. 2011 May;57(5):918-26. doi: 10.1161/HYPERTENSIONAHA.110.161349. Epub 2011 Mar 21.


Neuronal Shp2 tyrosine phosphatase controls energy balance and metabolism.

Zhang EE, Chapeau E, Hagihara K, Feng GS.

Proc Natl Acad Sci U S A. 2004 Nov 9;101(45):16064-9. Epub 2004 Nov 1.


Role of proopiomelanocortin neuron Stat3 in regulating arterial pressure and mediating the chronic effects of leptin.

Dubinion JH, do Carmo JM, Adi A, Hamza S, da Silva AA, Hall JE.

Hypertension. 2013 May;61(5):1066-74. doi: 10.1161/HYPERTENSIONAHA.111.00020. Epub 2013 Mar 25.


Regulation of Blood Pressure, Appetite, and Glucose by Leptin After Inactivation of Insulin Receptor Substrate 2 Signaling in the Entire Brain or in Proopiomelanocortin Neurons.

do Carmo JM, da Silva AA, Wang Z, Freeman NJ, Alsheik AJ, Adi A, Hall JE.

Hypertension. 2016 Feb;67(2):378-86. doi: 10.1161/HYPERTENSIONAHA.115.06153. Epub 2015 Nov 30.


Differential control of metabolic and cardiovascular functions by melanocortin-4 receptors in proopiomelanocortin neurons.

do Carmo JM, da Silva AA, Rushing JS, Pace B, Hall JE.

Am J Physiol Regul Integr Comp Physiol. 2013 Aug 15;305(4):R359-68. doi: 10.1152/ajpregu.00518.2012. Epub 2013 Jul 10.


Shp2 controls female body weight and energy balance by integrating leptin and estrogen signals.

He Z, Zhang SS, Meng Q, Li S, Zhu HH, Raquil MA, Alderson N, Zhang H, Wu J, Rui L, Cai D, Feng GS.

Mol Cell Biol. 2012 May;32(10):1867-78. doi: 10.1128/MCB.06712-11. Epub 2012 Mar 19.


Cardiovascular and metabolic responses to fasting and thermoneutrality are conserved in obese Zucker rats.

Overton JM, Williams TD, Chambers JB, Rashotte ME.

Am J Physiol Regul Integr Comp Physiol. 2001 Apr;280(4):R1007-15.


Disrupted Leptin Signaling in the Lateral Hypothalamus and Ventral Premammillary Nucleus Alters Insulin and Glucagon Secretion and Protects Against Diet-Induced Obesity.

Denroche HC, Glavas MM, Tudurí E, Karunakaran S, Quong WL, Philippe M, Britton HM, Clee SM, Kieffer TJ.

Endocrinology. 2016 Jul;157(7):2671-85. doi: 10.1210/en.2015-1998. Epub 2016 May 16.


Changes in ambient temperature elicit divergent control of metabolic and cardiovascular actions by leptin.

do Carmo JM, da Silva AA, Romero DG, Hall JE.

FASEB J. 2017 Jun;31(6):2418-2428. doi: 10.1096/fj.201601224R. Epub 2017 Feb 22.


Shp2 as a therapeutic target for leptin resistance and obesity.

Feng GS.

Expert Opin Ther Targets. 2006 Feb;10(1):135-42. Review.


Development of diabesity in mice with neuronal deletion of Shp2 tyrosine phosphatase.

Krajewska M, Banares S, Zhang EE, Huang X, Scadeng M, Jhala US, Feng GS, Krajewski S.

Am J Pathol. 2008 May;172(5):1312-24. doi: 10.2353/ajpath.2008.070594. Epub 2008 Apr 10.


Leptin receptor expression in hindbrain Glp-1 neurons regulates food intake and energy balance in mice.

Scott MM, Williams KW, Rossi J, Lee CE, Elmquist JK.

J Clin Invest. 2011 Jun;121(6):2413-21. doi: 10.1172/JCI43703. Epub 2011 May 23.


Brain-mediated antidiabetic, anorexic, and cardiovascular actions of leptin require melanocortin-4 receptor signaling.

da Silva AA, Spradley FT, Granger JP, Hall JE, do Carmo JM.

J Neurophysiol. 2015 Apr 1;113(7):2786-91. doi: 10.1152/jn.00911.2014. Epub 2015 Feb 25.


Cardiovascular and metabolic responses to fasting and thermoneutrality in Ay mice.

Williams TD, Chambers JB, Gagnon SP, Roberts LM, Henderson RP, Overton JM.

Physiol Behav. 2003 Apr;78(4-5):615-23.


Distinct networks of leptin- and insulin-sensing neurons regulate thermogenic responses to nutritional and cold challenges.

Chong AC, Greendyk RA, Zeltser LM.

Diabetes. 2015 Jan;64(1):137-46. doi: 10.2337/db14-0567. Epub 2014 Aug 14.


Food intake reductions and increases in energetic responses by hindbrain leptin and melanotan II are enhanced in mice with POMC-specific PTP1B deficiency.

De Jonghe BC, Hayes MR, Zimmer DJ, Kanoski SE, Grill HJ, Bence KK.

Am J Physiol Endocrinol Metab. 2012 Sep 1;303(5):E644-51. doi: 10.1152/ajpendo.00009.2012. Epub 2012 Jul 3.


Diet-induced obesity and cardiovascular regulation in C57BL/6J mice.

Williams TD, Chambers JB, Roberts LM, Henderson RP, Overton JM.

Clin Exp Pharmacol Physiol. 2003 Oct;30(10):769-78.


Deletion of protein tyrosine phosphatase 1b in proopiomelanocortin neurons reduces neurogenic control of blood pressure and protects mice from leptin- and sympatho-mediated hypertension.

Bruder-Nascimento T, Butler BR, Herren DJ, Brands MW, Bence KK, Belin de Chantemèle EJ.

Pharmacol Res. 2015 Dec;102:235-44. doi: 10.1016/j.phrs.2015.10.012. Epub 2015 Oct 30.

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