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Overexpression of 4EBP1, p70S6K, Akt1 or Akt2 differentially promotes Coxsackievirus B3-induced apoptosis in HeLa cells.

Li X, Li Z, Zhou W, Xing X, Huang L, Tian L, Chen J, Chen C, Ma X, Yang Z.

Cell Death Dis. 2013 Sep 12;4:e803-9. doi: 10.1038/cddis.2013.331.


Both PI3K- and mTOR-signaling pathways take part in CVB3-induced apoptosis of Hela cells.

Li X, Zhang J, Chen Z, Yang L, Xing X, Ma X, Yang Z.

DNA Cell Biol. 2013 Jul;32(7):359-70. doi: 10.1089/dna.2013.2003. Epub 2013 May 25.


Protein kinase B/Akt regulates coxsackievirus B3 replication through a mechanism which is not caspase dependent.

Esfandiarei M, Luo H, Yanagawa B, Suarez A, Dabiri D, Zhang J, McManus BM.

J Virol. 2004 Apr;78(8):4289-98.


LY294002 and Rapamycin promote coxsackievirus-induced cytopathic effect and apoptosis via inhibition of PI3K/AKT/mTOR signaling pathway.

Chen Z, Yang L, Liu Y, Tang A, Li X, Zhang J, Yang Z.

Mol Cell Biochem. 2014 Jan;385(1-2):169-77. doi: 10.1007/s11010-013-1825-1. Epub 2013 Sep 27.


Overexpression of interferon-gamma-inducible GTPase inhibits coxsackievirus B3-induced apoptosis through the activation of the phosphatidylinositol 3-kinase/Akt pathway and inhibition of viral replication.

Zhang HM, Yuan J, Cheung P, Luo H, Yanagawa B, Chau D, Stephan-Tozy N, Wong BW, Zhang J, Wilson JE, McManus BM, Yang D.

J Biol Chem. 2003 Aug 29;278(35):33011-9. Epub 2003 Jun 20.


Activation of Akt/mTOR pathway is associated with poor prognosis of nasopharyngeal carcinoma.

Wang W, Wen Q, Xu L, Xie G, Li J, Luo J, Chu S, Shi L, Huang D, Li J, Fan S.

PLoS One. 2014 Aug 28;9(8):e106098. doi: 10.1371/journal.pone.0106098. eCollection 2014.


The anti-apoptotic function of human αA-crystallin is directly related to its chaperone activity.

Pasupuleti N, Matsuyama S, Voss O, Doseff AI, Song K, Danielpour D, Nagaraj RH.

Cell Death Dis. 2010;1:e31. doi: 10.1038/cddis.2010.3.


Dual inhibition of Bcl-2 and Bcl-xL strikingly enhances PI3K inhibition-induced apoptosis in human myeloid leukemia cells through a GSK3- and Bim-dependent mechanism.

Rahmani M, Aust MM, Attkisson E, Williams DC Jr, Ferreira-Gonzalez A, Grant S.

Cancer Res. 2013 Feb 15;73(4):1340-51. doi: 10.1158/0008-5472.CAN-12-1365. Epub 2012 Dec 12.


Immunohistochemical analysis of the mammalian target of rapamycin signalling pathway in extramammary Paget's disease.

Chen S, Nakahara T, Uchi H, Takeuchi S, Takahara M, Kido M, Dugu L, Tu Y, Moroi Y, Furue M.

Br J Dermatol. 2009 Aug;161(2):357-63. doi: 10.1111/j.1365-2133.2009.09179.x. Epub 2009 Apr 29.


Activation of mammalian target of rapamycin signaling promotes cell cycle progression and protects cells from apoptosis in mantle cell lymphoma.

Peponi E, Drakos E, Reyes G, Leventaki V, Rassidakis GZ, Medeiros LJ.

Am J Pathol. 2006 Dec;169(6):2171-80.


4EBP1/eIF4E and p70S6K/RPS6 axes play critical and distinct roles in hepatocarcinogenesis driven by AKT and N-Ras proto-oncogenes in mice.

Wang C, Cigliano A, Jiang L, Li X, Fan B, Pilo MG, Liu Y, Gui B, Sini M, Smith JW, Dombrowski F, Calvisi DF, Evert M, Chen X.

Hepatology. 2015 Jan;61(1):200-13. doi: 10.1002/hep.27396. Epub 2014 Nov 25.


[Role of dysregulation of Bim in resistance of melanoma cells to endoplasmic reticulum stress-induced apoptosis].

Hou LL, Jin L, Han CC, Cheng B, Wang L, Zhang XD, Zhang LJ.

Zhonghua Zhong Liu Za Zhi. 2011 Jul;33(7):494-8. Chinese.


The role of RhoC in ovarian epithelial carcinoma: a marker for carcinogenesis, progression, prognosis, and target therapy.

Zhao Y, Zheng HC, Chen S, Gou WF, Xiao LJ, Niu ZF.

Gynecol Oncol. 2013 Sep;130(3):570-8. doi: 10.1016/j.ygyno.2013.06.004. Epub 2013 Jun 10.


The BH3-only protein Bim plays a critical role in leukemia cell death triggered by concomitant inhibition of the PI3K/Akt and MEK/ERK1/2 pathways.

Rahmani M, Anderson A, Habibi JR, Crabtree TR, Mayo M, Harada H, Ferreira-Gonzalez A, Dent P, Grant S.

Blood. 2009 Nov 12;114(20):4507-16. doi: 10.1182/blood-2008-09-177881. Epub 2009 Sep 22.


Effects of Livin gene RNA interference on apoptosis of cervical cancer HeLa cells and enhanced sensitivity to cisplatin.

Yu L, Wang Z.

J Huazhong Univ Sci Technolog Med Sci. 2009 Oct;29(5):625-30. doi: 10.1007/s11596-009-0518-1. Epub 2009 Oct 11.


[Effect and mechanism of an autophagy gene beclin 1 on cervical cancer HeLa cells].

Wang ZH, Li L, Duan ZL.

Zhonghua Fu Chan Ke Za Zhi. 2011 Feb;46(2):125-31. Chinese.


FoxO proteins' nuclear retention and BH3-only protein Bim induction evoke mitochondrial dysfunction-mediated apoptosis in berberine-treated HepG2 cells.

Shukla S, Rizvi F, Raisuddin S, Kakkar P.

Free Radic Biol Med. 2014 Nov;76:185-99. doi: 10.1016/j.freeradbiomed.2014.07.039. Epub 2014 Aug 13.


A comprehensive immunohistochemical and molecular approach to the PI3K/AKT/mTOR (phosphoinositide 3-kinase/v-akt murine thymoma viral oncogene/mammalian target of rapamycin) pathway in bladder urothelial carcinoma.

Korkolopoulou P, Levidou G, Trigka EA, Prekete N, Karlou M, Thymara I, Sakellariou S, Fragkou P, Isaiadis D, Pavlopoulos P, Patsouris E, Saetta AA.

BJU Int. 2012 Dec;110(11 Pt C):E1237-48. doi: 10.1111/j.1464-410X.2012.11569.x. Epub 2012 Oct 29.

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