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Chemopreventive effects of the p53-modulating agents CP-31398 and Prima-1 in tobacco carcinogen-induced lung tumorigenesis in A/J mice.

Rao CV, Patlolla JM, Qian L, Zhang Y, Brewer M, Mohammed A, Desai D, Amin S, Lightfoot S, Kopelovich L.

Neoplasia. 2013 Sep;15(9):1018-27.


Phenethyl isothiocyanate and sulforaphane and their N-acetylcysteine conjugates inhibit malignant progression of lung adenomas induced by tobacco carcinogens in A/J mice.

Conaway CC, Wang CX, Pittman B, Yang YM, Schwartz JE, Tian D, McIntee EJ, Hecht SS, Chung FL.

Cancer Res. 2005 Sep 15;65(18):8548-57.


β-Escin inhibits NNK-induced lung adenocarcinoma and ALDH1A1 and RhoA/Rock expression in A/J mice and growth of H460 human lung cancer cells.

Patlolla JM, Qian L, Biddick L, Zhang Y, Desai D, Amin S, Lightfoot S, Rao CV.

Cancer Prev Res (Phila). 2013 Oct;6(10):1140-9. doi: 10.1158/1940-6207.CAPR-13-0216. Epub 2013 Aug 20.


Inhibition of azoxymethane-induced colorectal cancer by CP-31398, a TP53 modulator, alone or in combination with low doses of celecoxib in male F344 rats.

Rao CV, Steele VE, Swamy MV, Patlolla JM, Guruswamy S, Kopelovich L.

Cancer Res. 2009 Oct 15;69(20):8175-82. doi: 10.1158/0008-5472.CAN-09-1377. Epub 2009 Oct 13.


Early and delayed intervention with rapamycin prevents NNK-induced lung adenocarcinoma in A/J mice.

Patlolla JM, Kopelovich L, Qian L, Zhang Y, Kumar G, Madka V, Mohammed A, Biddick L, Sadeghi M, Lightfoot S, Rao CV.

Oncol Rep. 2015 Dec;34(6):2925-34. doi: 10.3892/or.2015.4277. Epub 2015 Sep 16.


Chemopreventive efficacy of arylalkyl isothiocyanates and N-acetylcysteine for lung tumorigenesis in Fischer rats.

Chung FL, Kelloff G, Steele V, Pittman B, Zang E, Jiao D, Rigotty J, Choi CI, Rivenson A.

Cancer Res. 1996 Feb 15;56(4):772-8.


Combinations of indole-3-carbinol and silibinin suppress inflammation-driven mouse lung tumorigenesis by modulating critical cell cycle regulators.

Song JM, Qian X, Molla K, Teferi F, Upadhyaya P, O Sullivan G, Luo X, Kassie F.

Carcinogenesis. 2015 Jun;36(6):666-75. doi: 10.1093/carcin/bgv054. Epub 2015 Apr 20.


Dose-dependent inhibition of tobacco smoke carcinogen-induced lung tumorigenesis in A/J mice by indole-3-carbinol.

Kassie F, Matise I, Negia M, Upadhyaya P, Hecht SS.

Cancer Prev Res (Phila). 2008 Dec;1(7):568-76. doi: 10.1158/1940-6207.CAPR-08-0064.


K-ras mutations in lung tumors from A/J and A/J x TSG-p53 F1 mice treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and phenethyl isothiocyanate.

Matzinger SA, Crist KA, Stoner GD, Anderson MW, Pereira MA, Steele VE, Kelloff GJ, Lubet RA, You M.

Carcinogenesis. 1995 Oct;16(10):2487-92.


Effect of gefitinib on N-nitrosamine-4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induced lung tumorigenesis in A/J mice.

Kishino D, Kiura K, Takigawa N, Katayama H, Kuyama S, Sato K, Okada T, Ohashi K, Tanimoto M.

Lung Cancer. 2009 Sep;65(3):284-9. doi: 10.1016/j.lungcan.2008.11.021. Epub 2009 Jan 18.


Chemoprevention of lung tumorigenesis by intranasally administered diindolylmethane in A/J mice.

Qian X, Song JM, Melkamu T, Upadhyaya P, Kassie F.

Carcinogenesis. 2013 Apr;34(4):841-9. doi: 10.1093/carcin/bgs390. Epub 2012 Dec 13.


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