Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 194


cGMP accumulation causes photoreceptor degeneration in CNG channel deficiency: evidence of cGMP cytotoxicity independently of enhanced CNG channel function.

Xu J, Morris L, Thapa A, Ma H, Michalakis S, Biel M, Baehr W, Peshenko IV, Dizhoor AM, Ding XQ.

J Neurosci. 2013 Sep 11;33(37):14939-48. doi: 10.1523/JNEUROSCI.0909-13.2013.


cGMP/Protein Kinase G Signaling Suppresses Inositol 1,4,5-Trisphosphate Receptor Phosphorylation and Promotes Endoplasmic Reticulum Stress in Photoreceptors of Cyclic Nucleotide-gated Channel-deficient Mice.

Ma H, Butler MR, Thapa A, Belcher J, Yang F, Baehr W, Biel M, Michalakis S, Ding XQ.

J Biol Chem. 2015 Aug 21;290(34):20880-92. doi: 10.1074/jbc.M115.641159. Epub 2015 Jun 29.


Endoplasmic reticulum stress-associated cone photoreceptor degeneration in cyclic nucleotide-gated channel deficiency.

Thapa A, Morris L, Xu J, Ma H, Michalakis S, Biel M, Ding XQ.

J Biol Chem. 2012 May 25;287(22):18018-29. doi: 10.1074/jbc.M112.342220. Epub 2012 Apr 9.


Native cone photoreceptor cyclic nucleotide-gated channel is a heterotetrameric complex comprising both CNGA3 and CNGB3: a study using the cone-dominant retina of Nrl-/- mice.

Matveev AV, Quiambao AB, Browning Fitzgerald J, Ding XQ.

J Neurochem. 2008 Sep;106(5):2042-55. doi: 10.1111/j.1471-4159.2008.05548.x. Epub 2008 Jul 4.


shRNA knockdown of guanylate cyclase 2e or cyclic nucleotide gated channel alpha 1 increases photoreceptor survival in a cGMP phosphodiesterase mouse model of retinitis pigmentosa.

Tosi J, Davis RJ, Wang NK, Naumann M, Lin CS, Tsang SH.

J Cell Mol Med. 2011 Aug;15(8):1778-87. doi: 10.1111/j.1582-4934.2010.01201.x.


Loss of cone cyclic nucleotide-gated channel leads to alterations in light response modulating system and cellular stress response pathways: a gene expression profiling study.

Ma H, Thapa A, Morris LM, Michalakis S, Biel M, Frank MB, Bebak M, Ding XQ.

Hum Mol Genet. 2013 Oct 1;22(19):3906-19. doi: 10.1093/hmg/ddt245. Epub 2013 Jun 4.


Impaired opsin targeting and cone photoreceptor migration in the retina of mice lacking the cyclic nucleotide-gated channel CNGA3.

Michalakis S, Geiger H, Haverkamp S, Hofmann F, Gerstner A, Biel M.

Invest Ophthalmol Vis Sci. 2005 Apr;46(4):1516-24.


Matrix metalloproteinase-9 and -2 enhance the ligand sensitivity of photoreceptor cyclic nucleotide-gated channels.

Meighan PC, Meighan SE, Rich ED, Brown RL, Varnum MD.

Channels (Austin). 2012 May-Jun;6(3):181-96. doi: 10.4161/chan.20904. Epub 2012 May 1.


CNGA3 deficiency affects cone synaptic terminal structure and function and leads to secondary rod dysfunction and degeneration.

Xu J, Morris LM, Michalakis S, Biel M, Fliesler SJ, Sherry DM, Ding XQ.

Invest Ophthalmol Vis Sci. 2012 Mar 1;53(3):1117-29. doi: 10.1167/iovs.11-8168.


Transmembrane S1 mutations in CNGA3 from achromatopsia 2 patients cause loss of function and impaired cellular trafficking of the cone CNG channel.

Patel KA, Bartoli KM, Fandino RA, Ngatchou AN, Woch G, Carey J, Tanaka JC.

Invest Ophthalmol Vis Sci. 2005 Jul;46(7):2282-90.


A key role for cyclic nucleotide gated (CNG) channels in cGMP-related retinitis pigmentosa.

Paquet-Durand F, Beck S, Michalakis S, Goldmann T, Huber G, Mühlfriedel R, Trifunović D, Fischer MD, Fahl E, Duetsch G, Becirovic E, Wolfrum U, van Veen T, Biel M, Tanimoto N, Seeliger MW.

Hum Mol Genet. 2011 Mar 1;20(5):941-7. doi: 10.1093/hmg/ddq539. Epub 2010 Dec 10.


Impairment of rod cGMP-gated channel alpha-subunit expression leads to photoreceptor and bipolar cell degeneration.

Leconte L, Barnstable CJ.

Invest Ophthalmol Vis Sci. 2000 Mar;41(3):917-26.


CNG-modulin: a novel Ca-dependent modulator of ligand sensitivity in cone photoreceptor cGMP-gated ion channels.

Rebrik TI, Botchkina I, Arshavsky VY, Craft CM, Korenbrot JI.

J Neurosci. 2012 Feb 29;32(9):3142-53. doi: 10.1523/JNEUROSCI.5518-11.2012.


Disease-associated mutations in CNGB3 promote cytotoxicity in photoreceptor-derived cells.

Liu C, Sherpa T, Varnum MD.

Mol Vis. 2013 Jun 11;19:1268-81. Print 2013.


Natriuretic peptides and nitric oxide stimulate cGMP synthesis in different cellular compartments.

Piggott LA, Hassell KA, Berkova Z, Morris AP, Silberbach M, Rich TC.

J Gen Physiol. 2006 Jul;128(1):3-14. Epub 2006 Jun 12.


Impaired channel targeting and retinal degeneration in mice lacking the cyclic nucleotide-gated channel subunit CNGB1.

Hüttl S, Michalakis S, Seeliger M, Luo DG, Acar N, Geiger H, Hudl K, Mader R, Haverkamp S, Moser M, Pfeifer A, Gerstner A, Yau KW, Biel M.

J Neurosci. 2005 Jan 5;25(1):130-8.


Loss of HCN1 enhances disease progression in mouse models of CNG channel-linked retinitis pigmentosa and achromatopsia.

Schön C, Asteriti S, Koch S, Sothilingam V, Garcia Garrido M, Tanimoto N, Herms J, Seeliger MW, Cangiano L, Biel M, Michalakis S.

Hum Mol Genet. 2016 Mar 15;25(6):1165-75. doi: 10.1093/hmg/ddv639. Epub 2016 Jan 5.


The B3 Subunit of the Cone Cyclic Nucleotide-gated Channel Regulates the Light Responses of Cones and Contributes to the Channel Structural Flexibility.

Ding XQ, Thapa A, Ma H, Xu J, Elliott MH, Rodgers KK, Smith ML, Wang JS, Pittler SJ, Kefalov VJ.

J Biol Chem. 2016 Apr 15;291(16):8721-34. doi: 10.1074/jbc.M115.696138. Epub 2016 Feb 18.


Alternative splicing governs cone cyclic nucleotide-gated (CNG) channel sensitivity to regulation by phosphoinositides.

Dai G, Sherpa T, Varnum MD.

J Biol Chem. 2014 May 9;289(19):13680-90. doi: 10.1074/jbc.M114.562272. Epub 2014 Mar 27.


Defective trafficking of cone photoreceptor CNG channels induces the unfolded protein response and ER-stress-associated cell death.

Duricka DL, Brown RL, Varnum MD.

Biochem J. 2012 Jan 15;441(2):685-96. doi: 10.1042/BJ20111004.

Supplemental Content

Support Center