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Items: 1 to 20 of 204

1.

Contribution of GTPase activity to LRRK2-associated Parkinson disease.

Tsika E, Moore DJ.

Small GTPases. 2013 Jul-Sep;4(3):164-70. doi: 10.4161/sgtp.25130. Epub 2013 Jun 10. Review.

2.

GTPase activity and neuronal toxicity of Parkinson's disease-associated LRRK2 is regulated by ArfGAP1.

Stafa K, Trancikova A, Webber PJ, Glauser L, West AB, Moore DJ.

PLoS Genet. 2012;8(2):e1002526. doi: 10.1371/journal.pgen.1002526. Epub 2012 Feb 9.

3.

GTPase activity regulates kinase activity and cellular phenotypes of Parkinson's disease-associated LRRK2.

Biosa A, Trancikova A, Civiero L, Glauser L, Bubacco L, Greggio E, Moore DJ.

Hum Mol Genet. 2013 Mar 15;22(6):1140-56. doi: 10.1093/hmg/dds522. Epub 2012 Dec 13.

4.

Leucine-rich repeat kinase 2 (LRRK2)/PARK8 possesses GTPase activity that is altered in familial Parkinson's disease R1441C/G mutants.

Li X, Tan YC, Poulose S, Olanow CW, Huang XY, Yue Z.

J Neurochem. 2007 Oct;103(1):238-47. Epub 2007 Jul 10.

5.

Conformational heterogeneity of the Roc domains in C. tepidum Roc-COR and implications for human LRRK2 Parkinson mutations.

Rudi K, Ho FY, Gilsbach BK, Pots H, Wittinghofer A, Kortholt A, Klare JP.

Biosci Rep. 2015 Aug 26;35(5). pii: e00254. doi: 10.1042/BSR20150128.

6.

LRRK2 GTPase dysfunction in the pathogenesis of Parkinson's disease.

Xiong Y, Dawson VL, Dawson TM.

Biochem Soc Trans. 2012 Oct;40(5):1074-9. Review.

7.

The GTPase function of LRRK2.

Taymans JM.

Biochem Soc Trans. 2012 Oct;40(5):1063-9. Review.

PMID:
22988866
8.

Mutations in the LRRK2 Roc-COR tandem domain link Parkinson's disease to Wnt signalling pathways.

Sancho RM, Law BM, Harvey K.

Hum Mol Genet. 2009 Oct 15;18(20):3955-68. doi: 10.1093/hmg/ddp337. Epub 2009 Jul 22.

9.

LRRK2 pathobiology in Parkinson's disease.

Martin I, Kim JW, Dawson VL, Dawson TM.

J Neurochem. 2014 Dec;131(5):554-65. doi: 10.1111/jnc.12949. Epub 2014 Oct 10. Review.

10.

Leucine-rich repeat kinase 2: relevance to Parkinson's disease.

Guo L, Wang W, Chen SG.

Int J Biochem Cell Biol. 2006;38(9):1469-75. Epub 2006 Mar 2. Review.

PMID:
16600664
11.

Adenoviral-mediated expression of G2019S LRRK2 induces striatal pathology in a kinase-dependent manner in a rat model of Parkinson's disease.

Tsika E, Nguyen AP, Dusonchet J, Colin P, Schneider BL, Moore DJ.

Neurobiol Dis. 2015 May;77:49-61. doi: 10.1016/j.nbd.2015.02.019. Epub 2015 Feb 28.

PMID:
25731749
12.

The Parkinson's disease-associated protein, leucine-rich repeat kinase 2 (LRRK2), is an authentic GTPase that stimulates kinase activity.

Guo L, Gandhi PN, Wang W, Petersen RB, Wilson-Delfosse AL, Chen SG.

Exp Cell Res. 2007 Oct 1;313(16):3658-70. Epub 2007 Jul 19.

13.

The Parkinson disease gene LRRK2: evolutionary and structural insights.

Marín I.

Mol Biol Evol. 2006 Dec;23(12):2423-33. Epub 2006 Sep 11.

14.

LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity.

Jaleel M, Nichols RJ, Deak M, Campbell DG, Gillardon F, Knebel A, Alessi DR.

Biochem J. 2007 Jul 15;405(2):307-17.

15.

The biology and pathobiology of LRRK2: implications for Parkinson's disease.

Moore DJ.

Parkinsonism Relat Disord. 2008;14 Suppl 2:S92-8. doi: 10.1016/j.parkreldis.2008.04.010. Epub 2008 Jul 7. Review.

PMID:
18602856
16.

GTPase activity plays a key role in the pathobiology of LRRK2.

Xiong Y, Coombes CE, Kilaru A, Li X, Gitler AD, Bowers WJ, Dawson VL, Dawson TM, Moore DJ.

PLoS Genet. 2010 Apr 8;6(4):e1000902. doi: 10.1371/journal.pgen.1000902.

17.

Insight into the mode of action of the LRRK2 Y1699C pathogenic mutant.

Daniëls V, Vancraenenbroeck R, Law BM, Greggio E, Lobbestael E, Gao F, De Maeyer M, Cookson MR, Harvey K, Baekelandt V, Taymans JM.

J Neurochem. 2011 Jan;116(2):304-15. doi: 10.1111/j.1471-4159.2010.07105.x.

18.
19.

Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase.

Deng J, Lewis PA, Greggio E, Sluch E, Beilina A, Cookson MR.

Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1499-504. doi: 10.1073/pnas.0709098105. Epub 2008 Jan 29.

20.

The Parkinson's disease kinase LRRK2 autophosphorylates its GTPase domain at multiple sites.

Greggio E, Taymans JM, Zhen EY, Ryder J, Vancraenenbroeck R, Beilina A, Sun P, Deng J, Jaffe H, Baekelandt V, Merchant K, Cookson MR.

Biochem Biophys Res Commun. 2009 Nov 20;389(3):449-54. doi: 10.1016/j.bbrc.2009.08.163. Epub 2009 Sep 3.

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