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Items: 1 to 20 of 117


Novel role for the Streptococcus pneumoniae toxin pneumolysin in the assembly of biofilms.

Shak JR, Ludewick HP, Howery KE, Sakai F, Yi H, Harvey RM, Paton JC, Klugman KP, Vidal JE.

MBio. 2013 Sep 10;4(5):e00655-13. doi: 10.1128/mBio.00655-13.


The LuxS-dependent quorum-sensing system regulates early biofilm formation by Streptococcus pneumoniae strain D39.

Vidal JE, Ludewick HP, Kunkel RM, Zähner D, Klugman KP.

Infect Immun. 2011 Oct;79(10):4050-60. doi: 10.1128/IAI.05186-11. Epub 2011 Aug 8.


Streptococcus pneumoniae biofilm formation is strain dependent, multifactorial, and associated with reduced invasiveness and immunoreactivity during colonization.

Blanchette-Cain K, Hinojosa CA, Akula Suresh Babu R, Lizcano A, Gonzalez-Juarbe N, Munoz-Almagro C, Sanchez CJ, Bergman MA, Orihuela CJ.

MBio. 2013 Oct 15;4(5):e00745-13. doi: 10.1128/mBio.00745-13.


Viability and virulence of pneumolysin, pneumococcal surface protein A, and pneumolysin/pneumococcal surface protein A mutants in the ear.

Schachern PA, Tsuprun V, Goetz S, Cureoglu S, Juhn SK, Briles DE, Paparella MM, Ferrieri P.

JAMA Otolaryngol Head Neck Surg. 2013 Sep;139(9):937-43. doi: 10.1001/jamaoto.2013.4104.


Streptococcus pneumoniae biofilm formation and dispersion during colonization and disease.

Chao Y, Marks LR, Pettigrew MM, Hakansson AP.

Front Cell Infect Microbiol. 2015 Jan 13;4:194. doi: 10.3389/fcimb.2014.00194. eCollection 2014. Review.


Pneumolysin with low hemolytic activity confers an early growth advantage to Streptococcus pneumoniae in the blood.

Harvey RM, Ogunniyi AD, Chen AY, Paton JC.

Infect Immun. 2011 Oct;79(10):4122-30. doi: 10.1128/IAI.05418-11. Epub 2011 Jul 25.


Quorum-sensing systems LuxS/autoinducer 2 and Com regulate Streptococcus pneumoniae biofilms in a bioreactor with living cultures of human respiratory cells.

Vidal JE, Howery KE, Ludewick HP, Nava P, Klugman KP.

Infect Immun. 2013 Apr;81(4):1341-53. doi: 10.1128/IAI.01096-12. Epub 2013 Feb 12.


Pneumococcal interactions with epithelial cells are crucial for optimal biofilm formation and colonization in vitro and in vivo.

Marks LR, Parameswaran GI, Hakansson AP.

Infect Immun. 2012 Aug;80(8):2744-60. doi: 10.1128/IAI.00488-12. Epub 2012 May 29.


Dual function of pneumolysin in the early pathogenesis of murine pneumococcal pneumonia.

Rubins JB, Charboneau D, Paton JC, Mitchell TJ, Andrew PW, Janoff EN.

J Clin Invest. 1995 Jan;95(1):142-50.


Streptococcus pneumoniae in biofilms are unable to cause invasive disease due to altered virulence determinant production.

Sanchez CJ, Kumar N, Lizcano A, Shivshankar P, Dunning Hotopp JC, Jorgensen JH, Tettelin H, Orihuela CJ.

PLoS One. 2011;6(12):e28738. doi: 10.1371/journal.pone.0028738. Epub 2011 Dec 8.


Contributions of pneumolysin, pneumococcal surface protein A (PspA), and PspC to pathogenicity of Streptococcus pneumoniae D39 in a mouse model.

Ogunniyi AD, LeMessurier KS, Graham RM, Watt JM, Briles DE, Stroeher UH, Paton JC.

Infect Immun. 2007 Apr;75(4):1843-51. Epub 2007 Jan 29.


Identification of novel pneumolysin alleles from paediatric carriage isolates of Streptococcus pneumoniae.

Jefferies JM, Tocheva AS, Rubery H, Bennett J, Garland J, Christodoulides M, Faust SN, Smith A, Mitchell TJ, Clarke SC.

J Med Microbiol. 2010 Jul;59(Pt 7):808-14. doi: 10.1099/jmm.0.018663-0. Epub 2010 Mar 25.


Identification of invasive serotype 1 pneumococcal isolates that express nonhemolytic pneumolysin.

Kirkham LA, Jefferies JM, Kerr AR, Jing Y, Clarke SC, Smith A, Mitchell TJ.

J Clin Microbiol. 2006 Jan;44(1):151-9.


Pneumolysin localizes to the cell wall of Streptococcus pneumoniae.

Price KE, Camilli A.

J Bacteriol. 2009 Apr;191(7):2163-8. doi: 10.1128/JB.01489-08. Epub 2009 Jan 23.


Pneumolysin plays a key role at the initial step of establishing pneumococcal nasal colonization.

Hotomi M, Yuasa J, Briles DE, Yamanaka N.

Folia Microbiol (Praha). 2016 Sep;61(5):375-83. doi: 10.1007/s12223-016-0445-z. Epub 2016 Jan 23.


High levels of genetic recombination during nasopharyngeal carriage and biofilm formation in Streptococcus pneumoniae.

Marks LR, Reddinger RM, Hakansson AP.

MBio. 2012 Sep 25;3(5). pii: e00200-12. doi: 10.1128/mBio.00200-12. Print 2012.


The cholesterol-dependent cytolysin pneumolysin from Streptococcus pneumoniae binds to lipid raft microdomains in human corneal epithelial cells.

Taylor SD, Sanders ME, Tullos NA, Stray SJ, Norcross EW, McDaniel LS, Marquart ME.

PLoS One. 2013;8(4):e61300. doi: 10.1371/journal.pone.0061300. Epub 2013 Apr 5.


Early biofilm formation on microtiter plates is not correlated with the invasive disease potential of Streptococcus pneumoniae.

Lizcano A, Chin T, Sauer K, Tuomanen EI, Orihuela CJ.

Microb Pathog. 2010 Mar-Apr;48(3-4):124-30. doi: 10.1016/j.micpath.2010.01.002. Epub 2010 Jan 22.


Detoxified pneumolysin derivative Plym2 directly protects against pneumococcal infection via induction of inflammatory cytokines.

Lu J, Sun T, Hou H, Xu M, Gu T, Dong Y, Wang D, Chen P, Wu C, Liang C, Sun S, Jiang C, Kong W, Wu Y.

Immunol Invest. 2014;43(7):717-26. doi: 10.3109/08820139.2014.930478. Epub 2014 Jul 14.


Pneumolysin activates macrophage lysosomal membrane permeabilization and executes apoptosis by distinct mechanisms without membrane pore formation.

Bewley MA, Naughton M, Preston J, Mitchell A, Holmes A, Marriott HM, Read RC, Mitchell TJ, Whyte MK, Dockrell DH.

MBio. 2014 Oct 7;5(5):e01710-14. doi: 10.1128/mBio.01710-14.

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