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Items: 1 to 20 of 87

1.

3-O-methylthespesilactam, a new small-molecule anticancer pan-JAK inhibitor against A2058 human melanoma cells.

Li MY, Tian Y, Shen L, Buettner R, Li HZ, Liu L, Yuan YC, Xiao Q, Wu J, Jove R.

Biochem Pharmacol. 2013 Nov 15;86(10):1411-8. doi: 10.1016/j.bcp.2013.08.065. Epub 2013 Sep 7.

PMID:
24021352
2.

6-Bromoindirubin-3'-oxime inhibits JAK/STAT3 signaling and induces apoptosis of human melanoma cells.

Liu L, Nam S, Tian Y, Yang F, Wu J, Wang Y, Scuto A, Polychronopoulos P, Magiatis P, Skaltsounis L, Jove R.

Cancer Res. 2011 Jun 1;71(11):3972-9. doi: 10.1158/0008-5472.CAN-10-3852. Epub 2011 May 24.

3.

A novel 7-bromoindirubin with potent anticancer activity suppresses survival of human melanoma cells associated with inhibition of STAT3 and Akt signaling.

Liu L, Kritsanida M, Magiatis P, Gaboriaud N, Wang Y, Wu J, Buettner R, Yang F, Nam S, Skaltsounis L, Jove R.

Cancer Biol Ther. 2012 Nov;13(13):1255-61. doi: 10.4161/cbt.21781. Epub 2012 Aug 16.

4.

17-hydroxy-jolkinolide B inhibits signal transducers and activators of transcription 3 signaling by covalently cross-linking Janus kinases and induces apoptosis of human cancer cells.

Wang Y, Ma X, Yan S, Shen S, Zhu H, Gu Y, Wang H, Qin G, Yu Q.

Cancer Res. 2009 Sep 15;69(18):7302-10. doi: 10.1158/0008-5472.CAN-09-0462. Epub 2009 Aug 25.

5.

Inhibitors of JAK2 and JAK3: an update on the patent literature 2010 - 2012.

Dymock BW, See CS.

Expert Opin Ther Pat. 2013 Apr;23(4):449-501. doi: 10.1517/13543776.2013.765862. Epub 2013 Feb 1. Review.

PMID:
23367873
6.

Jak inhibitor induces S phase cell-cycle arrest and augments TRAIL-induced apoptosis in human hepatocellular carcinoma cells.

Fuke H, Shiraki K, Sugimoto K, Tanaka J, Beppu T, Yoneda K, Yamamoto N, Ito K, Masuya M, Takei Y.

Biochem Biophys Res Commun. 2007 Nov 23;363(3):738-44. Epub 2007 Sep 21.

PMID:
17904524
7.

A novel requirement for Janus kinases as mediators of drug resistance induced by fibroblast growth factor-2 in human cancer cells.

Carmo CR, Lyons-Lewis J, Seckl MJ, Costa-Pereira AP.

PLoS One. 2011;6(5):e19861. doi: 10.1371/journal.pone.0019861. Epub 2011 May 20.

8.

Hirsutane sesquiterpenoids from the marine-derived fungus Chondrostereum sp.

Li HJ, Lan WJ, Lam CK, Yang F, Zhu XF.

Chem Biodivers. 2011 Feb;8(2):317-24. doi: 10.1002/cbdv.201000036.

PMID:
21337504
9.

SD-1029 inhibits signal transducer and activator of transcription 3 nuclear translocation.

Duan Z, Bradner JE, Greenberg E, Levine R, Foster R, Mahoney J, Seiden MV.

Clin Cancer Res. 2006 Nov 15;12(22):6844-52.

10.

Cell density dependent increase of constitutive signal transducers and activators of transcription 3 activity in melanoma cells is mediated by Janus kinases.

Kreis S, Munz GA, Haan S, Heinrich PC, Behrmann I.

Mol Cancer Res. 2007 Dec;5(12):1331-41. doi: 10.1158/1541-7786.MCR-07-0317.

11.

JAK/STAT pathway plays a critical role in the proinflammatory gene expression and apoptosis of RAW264.7 cells induced by trichothecenes as DON and T-2 toxin.

Wang X, Liu Q, Ihsan A, Huang L, Dai M, Hao H, Cheng G, Liu Z, Wang Y, Yuan Z.

Toxicol Sci. 2012 Jun;127(2):412-24. doi: 10.1093/toxsci/kfs106. Epub 2012 Mar 27.

PMID:
22454431
12.

Advances in the discovery of selective JAK inhibitors.

Menet CJ, Rompaey LV, Geney R.

Prog Med Chem. 2013;52:153-223. doi: 10.1016/B978-0-444-62652-3.00004-1. Review.

PMID:
23384668
13.

Discovery, synthesis, and evaluation of small-molecule signal transducer and activator of transcription 3 inhibitors.

Shi ZB, Zhao D, Huang YY, Du Y, Cao XR, Gong ZN, Zhao R, Li JX.

Chem Pharm Bull (Tokyo). 2012;60(12):1574-80.

14.

Synthesis and structure-activity relationships for cytotoxicity and apoptosis-inducing activity of (+)-halichonine B.

Hayakawa I, Nakamura T, Ohno O, Suenaga K, Kigoshi H.

Org Biomol Chem. 2015 Oct 21;13(39):9969-76. doi: 10.1039/c5ob01488c.

PMID:
26287439
15.

Discovery of embelin as a cell-permeable, small-molecular weight inhibitor of XIAP through structure-based computational screening of a traditional herbal medicine three-dimensional structure database.

Nikolovska-Coleska Z, Xu L, Hu Z, Tomita Y, Li P, Roller PP, Wang R, Fang X, Guo R, Zhang M, Lippman ME, Yang D, Wang S.

J Med Chem. 2004 May 6;47(10):2430-40.

PMID:
15115387
16.

INCB16562, a JAK1/2 selective inhibitor, is efficacious against multiple myeloma cells and reverses the protective effects of cytokine and stromal cell support.

Li J, Favata M, Kelley JA, Caulder E, Thomas B, Wen X, Sparks RB, Arvanitis A, Rogers JD, Combs AP, Vaddi K, Solomon KA, Scherle PA, Newton R, Fridman JS.

Neoplasia. 2010 Jan;12(1):28-38.

17.

Pyridone 6, a pan-Janus-activated kinase inhibitor, induces growth inhibition of multiple myeloma cells.

Pedranzini L, Dechow T, Berishaj M, Comenzo R, Zhou P, Azare J, Bornmann W, Bromberg J.

Cancer Res. 2006 Oct 1;66(19):9714-21.

18.

Design and synthesis of a quinazolinone natural product-templated library with cytotoxic activity.

Liu JF, Kaselj M, Isome Y, Ye P, Sargent K, Sprague K, Cherrak D, Wilson CJ, Si Y, Yohannes D, Ng SC.

J Comb Chem. 2006 Jan-Feb;8(1):7-10. No abstract available.

PMID:
16398546
19.

Morin inhibits STAT3 tyrosine 705 phosphorylation in tumor cells through activation of protein tyrosine phosphatase SHP1.

Gupta SC, Phromnoi K, Aggarwal BB.

Biochem Pharmacol. 2013 Apr 1;85(7):898-912. doi: 10.1016/j.bcp.2012.12.018. Epub 2012 Dec 29.

PMID:
23279849
20.

Design, synthesis, and biological evaluation of alcyopterosin A and illudalane derivatives as anticancer agents.

Finkielsztein LM, Bruno AM, Renou SG, Moltrasio Iglesias GY.

Bioorg Med Chem. 2006 Mar 15;14(6):1863-70.

PMID:
16321541

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