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Items: 1 to 20 of 136

1.

Dietary salt intake regulates WNK3-SPAK-NKCC1 phosphorylation cascade in mouse aorta through angiotensin II.

Zeniya M, Sohara E, Kita S, Iwamoto T, Susa K, Mori T, Oi K, Chiga M, Takahashi D, Yang SS, Lin SH, Rai T, Sasaki S, Uchida S.

Hypertension. 2013 Nov;62(5):872-8. doi: 10.1161/HYPERTENSIONAHA.113.01543. Epub 2013 Sep 9.

2.

Kelch-Like Protein 2 Mediates Angiotensin II-With No Lysine 3 Signaling in the Regulation of Vascular Tonus.

Zeniya M, Morimoto N, Takahashi D, Mori Y, Mori T, Ando F, Araki Y, Yoshizaki Y, Inoue Y, Isobe K, Nomura N, Oi K, Nishida H, Sasaki S, Sohara E, Rai T, Uchida S.

J Am Soc Nephrol. 2015 Sep;26(9):2129-38. doi: 10.1681/ASN.2014070639. Epub 2015 Jan 2.

3.

Effect of heterozygous deletion of WNK1 on the WNK-OSR1/ SPAK-NCC/NKCC1/NKCC2 signal cascade in the kidney and blood vessels.

Susa K, Kita S, Iwamoto T, Yang SS, Lin SH, Ohta A, Sohara E, Rai T, Sasaki S, Alessi DR, Uchida S.

Clin Exp Nephrol. 2012 Aug;16(4):530-8.

PMID:
22294159
4.

Modulation of NCC activity by low and high K(+) intake: insights into the signaling pathways involved.

Castañeda-Bueno M, Cervantes-Perez LG, Rojas-Vega L, Arroyo-Garza I, Vázquez N, Moreno E, Gamba G.

Am J Physiol Renal Physiol. 2014 Jun 15;306(12):F1507-19. doi: 10.1152/ajprenal.00255.2013. Epub 2014 Apr 23.

5.

Phosphatidylinositol 3-kinase/Akt signaling pathway activates the WNK-OSR1/SPAK-NCC phosphorylation cascade in hyperinsulinemic db/db mice.

Nishida H, Sohara E, Nomura N, Chiga M, Alessi DR, Rai T, Sasaki S, Uchida S.

Hypertension. 2012 Oct;60(4):981-90. doi: 10.1161/HYPERTENSIONAHA.112.201509. Epub 2012 Sep 4.

6.

Inhibition of WNK3 Kinase Signaling Reduces Brain Damage and Accelerates Neurological Recovery After Stroke.

Begum G, Yuan H, Kahle KT, Li L, Wang S, Shi Y, Shmukler BE, Yang SS, Lin SH, Alper SL, Sun D.

Stroke. 2015 Jul;46(7):1956-65. doi: 10.1161/STROKEAHA.115.008939. Epub 2015 Jun 11.

7.

A novel Ste20-related proline/alanine-rich kinase (SPAK)-independent pathway involving calcium-binding protein 39 (Cab39) and serine threonine kinase with no lysine member 4 (WNK4) in the activation of Na-K-Cl cotransporters.

Ponce-Coria J, Markadieu N, Austin TM, Flammang L, Rios K, Welling PA, Delpire E.

J Biol Chem. 2014 Jun 20;289(25):17680-8. doi: 10.1074/jbc.M113.540518. Epub 2014 May 8.

8.

SPAK/OSR1 regulate NKCC1 and WNK activity: analysis of WNK isoform interactions and activation by T-loop trans-autophosphorylation.

Thastrup JO, Rafiqi FH, Vitari AC, Pozo-Guisado E, Deak M, Mehellou Y, Alessi DR.

Biochem J. 2012 Jan 1;441(1):325-37. doi: 10.1042/BJ20111879.

9.

WNK1 regulates vasoconstriction and blood pressure response to α 1-adrenergic stimulation in mice.

Bergaya S, Faure S, Baudrie V, Rio M, Escoubet B, Bonnin P, Henrion D, Loirand G, Achard JM, Jeunemaitre X, Hadchouel J.

Hypertension. 2011 Sep;58(3):439-45. doi: 10.1161/HYPERTENSIONAHA.111.172429. Epub 2011 Jul 18.

10.

Chemical library screening for WNK signalling inhibitors using fluorescence correlation spectroscopy.

Mori T, Kikuchi E, Watanabe Y, Fujii S, Ishigami-Yuasa M, Kagechika H, Sohara E, Rai T, Sasaki S, Uchida S.

Biochem J. 2013 Nov 1;455(3):339-45. doi: 10.1042/BJ20130597.

PMID:
23981180
11.

Chronic Metabolic Acidosis Activates Renal Tubular Sodium Chloride Cotransporter through Angiotension II-dependent WNK4-SPAK Phosphorylation Pathway.

Fang YW, Yang SS, Cheng CJ, Tseng MH, Hsu HM, Lin SH.

Sci Rep. 2016 Jan 5;6:18360. doi: 10.1038/srep18360.

12.

SPAK deficiency corrects pseudohypoaldosteronism II caused by WNK4 mutation.

Chu PY, Cheng CJ, Wu YC, Fang YW, Chau T, Uchida S, Sasaki S, Yang SS, Lin SH.

PLoS One. 2013 Sep 11;8(9):e72969. doi: 10.1371/journal.pone.0072969. eCollection 2013.

13.

Dietary salt regulates the phosphorylation of OSR1/SPAK kinases and the sodium chloride cotransporter through aldosterone.

Chiga M, Rai T, Yang SS, Ohta A, Takizawa T, Sasaki S, Uchida S.

Kidney Int. 2008 Dec;74(11):1403-9. doi: 10.1038/ki.2008.451. Epub 2008 Sep 17.

14.

A minor role of WNK3 in regulating phosphorylation of renal NKCC2 and NCC co-transporters in vivo.

Oi K, Sohara E, Rai T, Misawa M, Chiga M, Alessi DR, Sasaki S, Uchida S.

Biol Open. 2012 Feb 15;1(2):120-7. doi: 10.1242/bio.2011048. Epub 2011 Nov 24.

15.

Role of the WNK-activated SPAK kinase in regulating blood pressure.

Rafiqi FH, Zuber AM, Glover M, Richardson C, Fleming S, Jovanović S, Jovanović A, O'Shaughnessy KM, Alessi DR.

EMBO Mol Med. 2010 Feb;2(2):63-75. doi: 10.1002/emmm.200900058.

16.

Effect of angiotensin II on the WNK-OSR1/SPAK-NCC phosphorylation cascade in cultured mpkDCT cells and in vivo mouse kidney.

Talati G, Ohta A, Rai T, Sohara E, Naito S, Vandewalle A, Sasaki S, Uchida S.

Biochem Biophys Res Commun. 2010 Mar 19;393(4):844-8. doi: 10.1016/j.bbrc.2010.02.096. Epub 2010 Feb 20.

PMID:
20175999
17.

Role of SPAK and OSR1 signalling in the regulation of NaCl cotransporters.

Mercier-Zuber A, O'Shaughnessy KM.

Curr Opin Nephrol Hypertens. 2011 Sep;20(5):534-40. doi: 10.1097/MNH.0b013e3283484b06. Review.

PMID:
21610494
18.

On the substrate recognition and negative regulation of SPAK, a kinase modulating Na+-K+-2Cl- cotransport activity.

Gagnon KB, Delpire E.

Am J Physiol Cell Physiol. 2010 Sep;299(3):C614-20. doi: 10.1152/ajpcell.00074.2010. Epub 2010 May 12. Erratum in: Am J Physiol Cell Physiol. 2010 Sep;299(3):C614.

19.

SPAK-knockout mice manifest Gitelman syndrome and impaired vasoconstriction.

Yang SS, Lo YF, Wu CC, Lin SW, Yeh CJ, Chu P, Sytwu HK, Uchida S, Sasaki S, Lin SH.

J Am Soc Nephrol. 2010 Nov;21(11):1868-77. doi: 10.1681/ASN.2009121295. Epub 2010 Sep 2.

20.

Discovery of Novel SPAK Inhibitors That Block WNK Kinase Signaling to Cation Chloride Transporters.

Kikuchi E, Mori T, Zeniya M, Isobe K, Ishigami-Yuasa M, Fujii S, Kagechika H, Ishihara T, Mizushima T, Sasaki S, Sohara E, Rai T, Uchida S.

J Am Soc Nephrol. 2015 Jul;26(7):1525-36. doi: 10.1681/ASN.2014060560. Epub 2014 Nov 5.

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