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Tricyclic compounds containing nonenolizable cyano enones. A novel class of highly potent anti-inflammatory and cytoprotective agents.

Honda T, Yoshizawa H, Sundararajan C, David E, Lajoie MJ, Favaloro FG Jr, Janosik T, Su X, Honda Y, Roebuck BD, Gribble GW.

J Med Chem. 2011 Mar 24;54(6):1762-78. doi: 10.1021/jm101445p. Epub 2011 Mar 1.



Zheng S, Resch D, Honda T, Jasinski JP.

Acta Crystallogr Sect E Struct Rep Online. 2012 Nov 1;68(Pt 11):o3095-6. doi: 10.1107/S1600536812041244. Epub 2012 Oct 10.


Antidepressant effects of TBE-31 and MCE-1, the novel Nrf2 activators, in an inflammation model of depression.

Yao W, Zhang JC, Ishima T, Ren Q, Yang C, Dong C, Ma M, Saito A, Honda T, Hashimoto K.

Eur J Pharmacol. 2016 Dec 15;793:21-27. doi: 10.1016/j.ejphar.2016.10.037. Epub 2016 Nov 1.


Synthesis, molecular modeling and NAD(P)H:quinone oxidoreductase 1 inducer activity of novel cyanoenone and enone benzenesulfonamides.

Ghorab MM, Higgins M, Alsaid MS, Arafa RK, Shahat AA, Dinkova-Kostova AT.

J Enzyme Inhib Med Chem. 2014 Dec;29(6):840-5. doi: 10.3109/14756366.2013.858146. Epub 2014 Jan 14.


Dynamic and coordinated regulation of KEAP1-NRF2-ARE and p53/p21 signaling pathways is associated with acetaminophen injury responsive liver regeneration.

Fan X, Chen P, Tan H, Zeng H, Jiang Y, Wang Y, Wang Y, Hou X, Bi H, Huang M.

Drug Metab Dispos. 2014 Sep;42(9):1532-9. doi: 10.1124/dmd.114.059394. Epub 2014 Jul 7.


New Monocyclic, Bicyclic, and Tricyclic Ethynylcyanodienones as Activators of the Keap1/Nrf2/ARE Pathway and Inhibitors of Inducible Nitric Oxide Synthase.

Li W, Zheng S, Higgins M, Morra RP Jr, Mendis AT, Chien CW, Ojima I, Mierke DF, Dinkova-Kostova AT, Honda T.

J Med Chem. 2015 Jun 11;58(11):4738-48. doi: 10.1021/acs.jmedchem.5b00393. Epub 2015 May 20.


Altered disposition of acetaminophen in Nrf2-null and Keap1-knockdown mice.

Reisman SA, Csanaky IL, Aleksunes LM, Klaassen CD.

Toxicol Sci. 2009 May;109(1):31-40. doi: 10.1093/toxsci/kfp047. Epub 2009 Feb 26.


NAD(P)H:quinone oxidoreductase 1 activity reduces hypertrophy in 3T3-L1 adipocytes.

Vomhof-DeKrey EE, Picklo MJ.

Free Radic Biol Med. 2012 Aug 15;53(4):690-700. doi: 10.1016/j.freeradbiomed.2012.05.047. Epub 2012 Jun 8.


Keap1 cysteine 288 as a potential target for diallyl trisulfide-induced Nrf2 activation.

Kim S, Lee HG, Park SA, Kundu JK, Keum YS, Cha YN, Na HK, Surh YJ.

PLoS One. 2014 Jan 28;9(1):e85984. doi: 10.1371/journal.pone.0085984. eCollection 2014.


Butylated hydroxyanisole induces distinct expression patterns of Nrf2 and detoxification enzymes in the liver and small intestine of C57BL/6 mice.

Luo L, Chen Y, Wu D, Shou J, Wang S, Ye J, Tang X, Wang XJ.

Toxicol Appl Pharmacol. 2015 Nov 1;288(3):339-48. doi: 10.1016/j.taap.2015.08.006. Epub 2015 Aug 18.


An exceptionally potent inducer of cytoprotective enzymes: elucidation of the structural features that determine inducer potency and reactivity with Keap1.

Dinkova-Kostova AT, Talalay P, Sharkey J, Zhang Y, Holtzclaw WD, Wang XJ, David E, Schiavoni KH, Finlayson S, Mierke DF, Honda T.

J Biol Chem. 2010 Oct 29;285(44):33747-55. doi: 10.1074/jbc.M110.163485. Epub 2010 Aug 26.


The hepatotoxic metabolite of acetaminophen directly activates the Keap1-Nrf2 cell defense system.

Copple IM, Goldring CE, Jenkins RE, Chia AJ, Randle LE, Hayes JD, Kitteringham NR, Park BK.

Hepatology. 2008 Oct;48(4):1292-301. doi: 10.1002/hep.22472.


Assurance of mitochondrial integrity and mammalian longevity by the p62-Keap1-Nrf2-Nqo1 cascade.

Kwon J, Han E, Bui CB, Shin W, Lee J, Lee S, Choi YB, Lee AH, Lee KH, Park C, Obin MS, Park SK, Seo YJ, Oh GT, Lee HW, Shin J.

EMBO Rep. 2012 Feb 1;13(2):150-6. doi: 10.1038/embor.2011.246.


Constitutive activation of nuclear factor-E2-related factor 2 induces biotransformation enzyme and transporter expression in livers of mice with hepatocyte-specific deletion of Kelch-like ECH-associated protein 1.

Cheng Q, Taguchi K, Aleksunes LM, Manautou JE, Cherrington NJ, Yamamoto M, Slitt AL.

J Biochem Mol Toxicol. 2011 Sep-Oct;25(5):320-9. doi: 10.1002/jbt.20392. Epub 2011 May 2.


Activation of NRF2 pathway in spleen, thymus as well as peripheral blood mononuclear cells by acute arsenic exposure in mice.

Duan X, Li J, Zhang Y, Li W, Zhao L, Nie H, Sun G, Li B.

Int Immunopharmacol. 2015 Oct;28(2):1059-67. doi: 10.1016/j.intimp.2015.08.025. Epub 2015 Sep 11.


2-(penta-1,3-diynyl)-5-(3,4-dihydroxybut-1-ynyl)thiophene, a novel NQO1 inducing agent from Echinops grijsii Hance.

Shi J, Zhang X, Jiang H.

Molecules. 2010 Aug 3;15(8):5273-81. doi: 10.3390/molecules15085273.

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