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Items: 1 to 20 of 111

1.

The chemical synthesis of α-conotoxins and structurally modified analogs with enhanced biological stability.

Banerjee J, Gyanda R, Chang YP, Armishaw CJ.

Methods Mol Biol. 2013;1081:13-34. doi: 10.1007/978-1-62703-652-8_2.

PMID:
24014431
2.

Establishing regiocontrol of disulfide bond isomers of alpha-conotoxin ImI via the synthesis of N-to-C cyclic analogs.

Armishaw CJ, Dutton JL, Craik DJ, Alewood PF.

Biopolymers. 2010;94(3):307-13. doi: 10.1002/bip.21360.

PMID:
20013812
3.

Oxidative folding and preparation of α-conotoxins for use in high-throughput structure-activity relationship studies.

Gyanda R, Banerjee J, Chang YP, Phillips AM, Toll L, Armishaw CJ.

J Pept Sci. 2013 Jan;19(1):16-24. doi: 10.1002/psc.2467. Epub 2012 Nov 28.

PMID:
23193084
4.

Stabilization of α-conotoxin AuIB: influences of disulfide connectivity and backbone cyclization.

Lovelace ES, Gunasekera S, Alvarmo C, Clark RJ, Nevin ST, Grishin AA, Adams DJ, Craik DJ, Daly NL.

Antioxid Redox Signal. 2011 Jan 1;14(1):87-95. doi: 10.1089/ars.2009.3068. Epub 2010 Aug 20.

PMID:
20486767
5.

Improving the stability of α-conotoxin AuIB through N-to-C cyclization: the effect of linker length on stability and activity at nicotinic acetylcholine receptors.

Armishaw CJ, Jensen AA, Balle LD, Scott KC, Sørensen L, Strømgaard K.

Antioxid Redox Signal. 2011 Jan 1;14(1):65-76. doi: 10.1089/ars.2010.3458. Epub 2010 Oct 19.

PMID:
20649464
6.

Conotoxins as research tools and drug leads.

Armishaw CJ, Alewood PF.

Curr Protein Pept Sci. 2005 Jun;6(3):221-40. Review.

PMID:
15974949
7.

A synthetic combinatorial strategy for developing alpha-conotoxin analogs as potent alpha7 nicotinic acetylcholine receptor antagonists.

Armishaw CJ, Singh N, Medina-Franco JL, Clark RJ, Scott KC, Houghten RA, Jensen AA.

J Biol Chem. 2010 Jan 15;285(3):1809-21. doi: 10.1074/jbc.M109.071183. Epub 2009 Nov 9.

8.

Enhanced microwave-assisted method for on-bead disulfide bond formation: synthesis of alpha-conotoxin MII.

Galanis AS, Albericio F, Grøtli M.

Biopolymers. 2009;92(1):23-34. doi: 10.1002/bip.21116.

PMID:
19003899
9.

lambda-conotoxins, a new family of conotoxins with unique disulfide pattern and protein folding. Isolation and characterization from the venom of Conus marmoreus.

Balaji RA, Ohtake A, Sato K, Gopalakrishnakone P, Kini RM, Seow KT, Bay BH.

J Biol Chem. 2000 Dec 15;275(50):39516-22.

11.

Cyclization of conotoxins to improve their biopharmaceutical properties.

Clark RJ, Akcan M, Kaas Q, Daly NL, Craik DJ.

Toxicon. 2012 Mar 15;59(4):446-55. doi: 10.1016/j.toxicon.2010.12.003. Epub 2010 Dec 10. Review.

PMID:
21147143
12.

Engineering of conotoxins for the treatment of pain.

Carstens BB, Clark RJ, Daly NL, Harvey PJ, Kaas Q, Craik DJ.

Curr Pharm Des. 2011 Dec;17(38):4242-53. Review.

PMID:
22204425
13.

Cosolvent-assisted oxidative folding of a bicyclic alpha-conotoxin ImI.

Nielsen JS, Buczek P, Bulaj G.

J Pept Sci. 2004 May;10(5):249-56.

PMID:
15160836
14.

Backbone cyclization of analgesic conotoxin GeXIVA facilitates direct folding of the ribbon isomer.

Wu X, Huang YH, Kaas Q, Harvey PJ, Wang CK, Tae HS, Adams DJ, Craik DJ.

J Biol Chem. 2017 Oct 13;292(41):17101-17112. doi: 10.1074/jbc.M117.808386. Epub 2017 Aug 28.

PMID:
28851841
15.
16.

A new level of conotoxin diversity, a non-native disulfide bond connectivity in alpha-conotoxin AuIB reduces structural definition but increases biological activity.

Dutton JL, Bansal PS, Hogg RC, Adams DJ, Alewood PF, Craik DJ.

J Biol Chem. 2002 Dec 13;277(50):48849-57. Epub 2002 Oct 9.

17.

Distinct disulfide isomers of μ-conotoxins KIIIA and KIIIB block voltage-gated sodium channels.

Khoo KK, Gupta K, Green BR, Zhang MM, Watkins M, Olivera BM, Balaram P, Yoshikami D, Bulaj G, Norton RS.

Biochemistry. 2012 Dec 11;51(49):9826-35. doi: 10.1021/bi301256s. Epub 2012 Nov 28.

18.

Structure of alpha-conotoxin BuIA: influences of disulfide connectivity on structural dynamics.

Jin AH, Brandstaetter H, Nevin ST, Tan CC, Clark RJ, Adams DJ, Alewood PF, Craik DJ, Daly NL.

BMC Struct Biol. 2007 Apr 20;7:28.

19.

Effects of cyclization on stability, structure, and activity of α-conotoxin RgIA at the α9α10 nicotinic acetylcholine receptor and GABA(B) receptor.

Halai R, Callaghan B, Daly NL, Clark RJ, Adams DJ, Craik DJ.

J Med Chem. 2011 Oct 13;54(19):6984-92. doi: 10.1021/jm201060r. Epub 2011 Sep 15.

PMID:
21888386
20.

Controlled syntheses of natural and disulfide-mispaired regioisomers of alpha-conotoxin SI.

Hargittai B, Barany G.

J Pept Res. 1999 Dec;54(6):468-79.

PMID:
10604592

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