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Items: 1 to 20 of 130

1.

The antihelmintic drug pyrvinium pamoate targets aggressive breast cancer.

Xu W, Lacerda L, Debeb BG, Atkinson RL, Solley TN, Li L, Orton D, McMurray JS, Hang BI, Lee E, Klopp AH, Ueno NT, Reuben JM, Krishnamurthy S, Woodward WA.

PLoS One. 2013 Aug 27;8(8):e71508. doi: 10.1371/journal.pone.0071508. eCollection 2013.

2.

WNT pathway inhibitor pyrvinium pamoate inhibits the self-renewal and metastasis of breast cancer stem cells.

Xu L, Zhang L, Hu C, Liang S, Fei X, Yan N, Zhang Y, Zhang F.

Int J Oncol. 2016 Mar;48(3):1175-86. doi: 10.3892/ijo.2016.3337. Epub 2016 Jan 13.

PMID:
26781188
3.

The impact of pyrvinium pamoate on colon cancer cell viability.

Wiegering A, Uthe FW, Hüttenrauch M, Mühling B, Linnebacher M, Krummenast F, Germer CT, Thalheimer A, Otto C.

Int J Colorectal Dis. 2014 Oct;29(10):1189-98. doi: 10.1007/s00384-014-1975-y. Epub 2014 Jul 26.

PMID:
25060218
4.

Wnt blockers inhibit the proliferation of lung cancer stem cells.

Zhang X, Lou Y, Zheng X, Wang H, Sun J, Dong Q, Han B.

Drug Des Devel Ther. 2015 Apr 28;9:2399-407. doi: 10.2147/DDDT.S76602. eCollection 2015.

5.

Sulforaphane, a dietary component of broccoli/broccoli sprouts, inhibits breast cancer stem cells.

Li Y, Zhang T, Korkaya H, Liu S, Lee HF, Newman B, Yu Y, Clouthier SG, Schwartz SJ, Wicha MS, Sun D.

Clin Cancer Res. 2010 May 1;16(9):2580-90. doi: 10.1158/1078-0432.CCR-09-2937. Epub 2010 Apr 13.

6.

Pre-clinical studies of Notch signaling inhibitor RO4929097 in inflammatory breast cancer cells.

Debeb BG, Cohen EN, Boley K, Freiter EM, Li L, Robertson FM, Reuben JM, Cristofanilli M, Buchholz TA, Woodward WA.

Breast Cancer Res Treat. 2012 Jul;134(2):495-510. doi: 10.1007/s10549-012-2075-8. Epub 2012 May 1.

7.

Histone deacetylase inhibitors stimulate dedifferentiation of human breast cancer cells through WNT/β-catenin signaling.

Debeb BG, Lacerda L, Xu W, Larson R, Solley T, Atkinson R, Sulman EP, Ueno NT, Krishnamurthy S, Reuben JM, Buchholz TA, Woodward WA.

Stem Cells. 2012 Nov;30(11):2366-77. doi: 10.1002/stem.1219.

8.

Baicalein suppresses metastasis of breast cancer cells by inhibiting EMT via downregulation of SATB1 and Wnt/β-catenin pathway.

Ma X, Yan W, Dai Z, Gao X, Ma Y, Xu Q, Jiang J, Zhang S.

Drug Des Devel Ther. 2016 Apr 18;10:1419-41. doi: 10.2147/DDDT.S102541. eCollection 2016.

9.

Pyrvinium Targets CD133 in Human Glioblastoma Brain Tumor-Initiating Cells.

Venugopal C, Hallett R, Vora P, Manoranjan B, Mahendram S, Qazi MA, McFarlane N, Subapanditha M, Nolte SM, Singh M, Bakhshinyan D, Garg N, Vijayakumar T, Lach B, Provias JP, Reddy K, Murty NK, Doble BW, Bhatia M, Hassell JA, Singh SK.

Clin Cancer Res. 2015 Dec 1;21(23):5324-37. doi: 10.1158/1078-0432.CCR-14-3147. Epub 2015 Jul 7.

10.

Compound Kushen Injection suppresses human breast cancer stem-like cells by down-regulating the canonical Wnt/β-catenin pathway.

Xu W, Lin H, Zhang Y, Chen X, Hua B, Hou W, Qi X, Pei Y, Zhu X, Zhao Z, Yang L.

J Exp Clin Cancer Res. 2011 Oct 28;30:103. doi: 10.1186/1756-9966-30-103.

11.

Targeting treatment-resistant breast cancer stem cells with FKBPL and its peptide derivative, AD-01, via the CD44 pathway.

McClements L, Yakkundi A, Papaspyropoulos A, Harrison H, Ablett MP, Jithesh PV, McKeen HD, Bennett R, Donley C, Kissenpfennig A, McIntosh S, McCarthy HO, O'Neill E, Clarke RB, Robson T.

Clin Cancer Res. 2013 Jul 15;19(14):3881-93. doi: 10.1158/1078-0432.CCR-13-0595. Epub 2013 Jun 5.

12.

Down-regulation of vitamin D receptor in mammospheres: implications for vitamin D resistance in breast cancer and potential for combination therapy.

Pervin S, Hewison M, Braga M, Tran L, Chun R, Karam A, Chaudhuri G, Norris K, Singh R.

PLoS One. 2013;8(1):e53287. doi: 10.1371/journal.pone.0053287. Epub 2013 Jan 14. Erratum in: PLoS One. 2013;8(10). doi:10.1371/annotation/5326d117-3f31-4e43-a5c4-9e1fb41719e9.

13.

Phosphosulindac (OXT-328) selectively targets breast cancer stem cells in vitro and in human breast cancer xenografts.

Zhu C, Cheng KW, Ouyang N, Huang L, Sun Y, Constantinides P, Rigas B.

Stem Cells. 2012 Oct;30(10):2065-75. doi: 10.1002/stem.1139.

14.

Salinomycin possesses anti-tumor activity and inhibits breast cancer stem-like cells via an apoptosis-independent pathway.

An H, Kim JY, Lee N, Cho Y, Oh E, Seo JH.

Biochem Biophys Res Commun. 2015 Oct 30;466(4):696-703. doi: 10.1016/j.bbrc.2015.09.108. Epub 2015 Sep 25.

PMID:
26407842
15.

Garcinol regulates EMT and Wnt signaling pathways in vitro and in vivo, leading to anticancer activity against breast cancer cells.

Ahmad A, Sarkar SH, Bitar B, Ali S, Aboukameel A, Sethi S, Li Y, Bao B, Kong D, Banerjee S, Padhye SB, Sarkar FH.

Mol Cancer Ther. 2012 Oct;11(10):2193-201. doi: 10.1158/1535-7163.MCT-12-0232-T. Epub 2012 Jul 19.

16.

Small molecule antagonists of the Wnt/β-catenin signaling pathway target breast tumor-initiating cells in a Her2/Neu mouse model of breast cancer.

Hallett RM, Kondratyev MK, Giacomelli AO, Nixon AM, Girgis-Gabardo A, Ilieva D, Hassell JA.

PLoS One. 2012;7(3):e33976. doi: 10.1371/journal.pone.0033976. Epub 2012 Mar 28.

17.

Effect of niclosamide on basal-like breast cancers.

Londoño-Joshi AI, Arend RC, Aristizabal L, Lu W, Samant RS, Metge BJ, Hidalgo B, Grizzle WE, Conner M, Forero-Torres A, Lobuglio AF, Li Y, Buchsbaum DJ.

Mol Cancer Ther. 2014 Apr;13(4):800-11. doi: 10.1158/1535-7163.MCT-13-0555. Epub 2014 Feb 19.

18.

Specific inhibition of Notch1 signaling enhances the antitumor efficacy of chemotherapy in triple negative breast cancer through reduction of cancer stem cells.

Qiu M, Peng Q, Jiang I, Carroll C, Han G, Rymer I, Lippincott J, Zachwieja J, Gajiwala K, Kraynov E, Thibault S, Stone D, Gao Y, Sofia S, Gallo J, Li G, Yang J, Li K, Wei P.

Cancer Lett. 2013 Jan 28;328(2):261-70. doi: 10.1016/j.canlet.2012.09.023. Epub 2012 Oct 3.

PMID:
23041621
19.

Ursolic acid inhibits the proliferation of human ovarian cancer stem-like cells through epithelial-mesenchymal transition.

Zhang J, Wang W, Qian L, Zhang Q, Lai D, Qi C.

Oncol Rep. 2015 Nov;34(5):2375-84. doi: 10.3892/or.2015.4213. Epub 2015 Aug 20.

PMID:
26323892
20.

LGR5 Promotes Breast Cancer Progression and Maintains Stem-Like Cells Through Activation of Wnt/β-Catenin Signaling.

Yang L, Tang H, Kong Y, Xie X, Chen J, Song C, Liu X, Ye F, Li N, Wang N, Xie X.

Stem Cells. 2015 Oct;33(10):2913-24. doi: 10.1002/stem.2083. Epub 2015 Jul 14.

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