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Co-operation of BRCA1 and POH1 relieves the barriers posed by 53BP1 and RAP80 to resection.

Kakarougkas A, Ismail A, Katsuki Y, Freire R, Shibata A, Jeggo PA.

Nucleic Acids Res. 2013 Dec;41(22):10298-311. doi: 10.1093/nar/gkt802. Epub 2013 Sep 5.


DNA DSB repair pathway choice: an orchestrated handover mechanism.

Kakarougkas A, Jeggo PA.

Br J Radiol. 2014 Mar;87(1035):20130685. doi: 10.1259/bjr.20130685. Review.


The ubiquitin-interacting motif containing protein RAP80 interacts with BRCA1 and functions in DNA damage repair response.

Yan J, Kim YS, Yang XP, Li LP, Liao G, Xia F, Jetten AM.

Cancer Res. 2007 Jul 15;67(14):6647-56. Epub 2007 Jul 9.


A small ubiquitin binding domain inhibits ubiquitin-dependent protein recruitment to DNA repair foci.

Helchowski CM, Skow LF, Roberts KH, Chute CL, Canman CE.

Cell Cycle. 2013 Dec 15;12(24):3749-58. doi: 10.4161/cc.26640. Epub 2013 Oct 3.


BRCA1-associated exclusion of 53BP1 from DNA damage sites underlies temporal control of DNA repair.

Chapman JR, Sossick AJ, Boulton SJ, Jackson SP.

J Cell Sci. 2012 Aug 1;125(Pt 15):3529-34. Epub 2012 May 2.


SETDB1, HP1 and SUV39 promote repositioning of 53BP1 to extend resection during homologous recombination in G2 cells.

Alagoz M, Katsuki Y, Ogiwara H, Ogi T, Shibata A, Kakarougkas A, Jeggo P.

Nucleic Acids Res. 2015 Sep 18;43(16):7931-44. doi: 10.1093/nar/gkv722. Epub 2015 Jul 22.


Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage.

Wang B, Elledge SJ.

Proc Natl Acad Sci U S A. 2007 Dec 26;104(52):20759-63. Epub 2007 Dec 5.


Three-dimensional imaging reveals the spatial separation of γH2AX-MDC1-53BP1 and RNF8-RNF168-BRCA1-A complexes at ionizing radiation-induced foci.

Mok MT, Henderson BR.

Radiother Oncol. 2012 Jun;103(3):415-20. doi: 10.1016/j.radonc.2012.04.009. Epub 2012 May 24.


The de-ubiquitylating enzymes USP26 and USP37 regulate homologous recombination by counteracting RAP80.

Typas D, Luijsterburg MS, Wiegant WW, Diakatou M, Helfricht A, Thijssen PE, van den Broek B, Mullenders LH, van Attikum H.

Nucleic Acids Res. 2015 Aug 18;43(14):6919-33. doi: 10.1093/nar/gkv613. Epub 2015 Jun 22. Erratum in: Nucleic Acids Res. 2016 Apr 7;44(6):2976. van de Broek, Bram [Corrected to van den Broek, Bram].


MERIT40 controls BRCA1-Rap80 complex integrity and recruitment to DNA double-strand breaks.

Shao G, Patterson-Fortin J, Messick TE, Feng D, Shanbhag N, Wang Y, Greenberg RA.

Genes Dev. 2009 Mar 15;23(6):740-54. doi: 10.1101/gad.1739609. Epub 2009 Mar 4.


BRCA1 Directs the Repair Pathway to Homologous Recombination by Promoting 53BP1 Dephosphorylation.

Isono M, Niimi A, Oike T, Hagiwara Y, Sato H, Sekine R, Yoshida Y, Isobe SY, Obuse C, Nishi R, Petricci E, Nakada S, Nakano T, Shibata A.

Cell Rep. 2017 Jan 10;18(2):520-532. doi: 10.1016/j.celrep.2016.12.042.


The proteasomal de-ubiquitinating enzyme POH1 promotes the double-strand DNA break response.

Butler LR, Densham RM, Jia J, Garvin AJ, Stone HR, Shah V, Weekes D, Festy F, Beesley J, Morris JR.

EMBO J. 2012 Oct 3;31(19):3918-34. doi: 10.1038/emboj.2012.232. Epub 2012 Aug 21.


Differences in 53BP1 and BRCA1 regulation between cycling and non-cycling cells.

Croke M, Neumann MA, Grotsky DA, Kreienkamp R, Yaddanapudi SC, Gonzalo S.

Cell Cycle. 2013 Dec 1;12(23):3629-39. doi: 10.4161/cc.26582. Epub 2013 Oct 2.


Human RNF169 is a negative regulator of the ubiquitin-dependent response to DNA double-strand breaks.

Poulsen M, Lukas C, Lukas J, Bekker-Jensen S, Mailand N.

J Cell Biol. 2012 Apr 16;197(2):189-99. doi: 10.1083/jcb.201109100. Epub 2012 Apr 9.


RING finger nuclear factor RNF168 is important for defects in homologous recombination caused by loss of the breast cancer susceptibility factor BRCA1.

Muñoz MC, Laulier C, Gunn A, Cheng A, Robbiani DF, Nussenzweig A, Stark JM.

J Biol Chem. 2012 Nov 23;287(48):40618-28. doi: 10.1074/jbc.M112.410951. Epub 2012 Oct 10.


NFBD1/MDC1, 53BP1 and BRCA1 have both redundant and unique roles in the ATM pathway.

Wilson KA, Stern DF.

Cell Cycle. 2008 Nov 15;7(22):3584-94. Epub 2008 Nov 29.


RAP80, ubiquitin and SUMO in the DNA damage response.

Lombardi PM, Matunis MJ, Wolberger C.

J Mol Med (Berl). 2017 Aug;95(8):799-807. doi: 10.1007/s00109-017-1561-1. Epub 2017 Jul 5. Review.


Differential regulation of JAMM domain deubiquitinating enzyme activity within the RAP80 complex.

Patterson-Fortin J, Shao G, Bretscher H, Messick TE, Greenberg RA.

J Biol Chem. 2010 Oct 1;285(40):30971-81. doi: 10.1074/jbc.M110.135319. Epub 2010 Jul 22.


RNF8 regulates assembly of RAD51 at DNA double-strand breaks in the absence of BRCA1 and 53BP1.

Nakada S, Yonamine RM, Matsuo K.

Cancer Res. 2012 Oct 1;72(19):4974-83. doi: 10.1158/0008-5472.CAN-12-1057. Epub 2012 Aug 3.


Mutations in the BRCT binding site of BRCA1 result in hyper-recombination.

Dever SM, Golding SE, Rosenberg E, Adams BR, Idowu MO, Quillin JM, Valerie N, Xu B, Povirk LF, Valerie K.

Aging (Albany NY). 2011 May;3(5):515-32.

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