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The MutSβ complex is a modulator of p53-driven tumorigenesis through its functions in both DNA double-strand break repair and mismatch repair.

van Oers JM, Edwards Y, Chahwan R, Zhang W, Smith C, Pechuan X, Schaetzlein S, Jin B, Wang Y, Bergman A, Scharff MD, Edelmann W.

Oncogene. 2014 Jul 24;33(30):3939-46. doi: 10.1038/onc.2013.365. Epub 2013 Sep 9.


The associated contributions of p53 and the DNA mismatch repair protein Msh6 to spontaneous tumorigenesis.

Young LC, Keuling AM, Lai R, Nation PN, Tron VA, Andrew SE.

Carcinogenesis. 2007 Oct;28(10):2131-8. Epub 2007 Jul 5.


ATP binding and hydrolysis by Saccharomyces cerevisiae Msh2-Msh3 are differentially modulated by mismatch and double-strand break repair DNA substrates.

Kumar C, Eichmiller R, Wang B, Williams GM, Bianco PR, Surtees JA.

DNA Repair (Amst). 2014 Jun;18:18-30. doi: 10.1016/j.dnarep.2014.03.032. Epub 2014 Apr 18.


The distinct spectra of tumor-associated Apc mutations in mismatch repair-deficient Apc1638N mice define the roles of MSH3 and MSH6 in DNA repair and intestinal tumorigenesis.

Kuraguchi M, Yang K, Wong E, Avdievich E, Fan K, Kolodner RD, Lipkin M, Brown AM, Kucherlapati R, Edelmann W.

Cancer Res. 2001 Nov 1;61(21):7934-42.


Polμ deficiency induces moderate shortening of P53-/- mouse lifespan and modifies tumor spectrum.

Escudero B, Herrero D, Torres Y, Cañón S, Molina A, Carmona RM, Suela J, Blanco L, Samper E, Bernad A.

DNA Repair (Amst). 2017 Jun;54:40-45. doi: 10.1016/j.dnarep.2017.04.001. Epub 2017 Apr 10.


Female embryonic lethality in mice nullizygous for both Msh2 and p53.

Cranston A, Bocker T, Reitmair A, Palazzo J, Wilson T, Mak T, Fishel R.

Nat Genet. 1997 Sep;17(1):114-8.


Mcph1/Brit1 deficiency promotes genomic instability and tumor formation in a mouse model.

Liang Y, Gao H, Lin SY, Goss JA, Du C, Li K.

Oncogene. 2015 Aug 13;34(33):4368-78. doi: 10.1038/onc.2014.367. Epub 2014 Nov 3.


EMAST is a Form of Microsatellite Instability That is Initiated by Inflammation and Modulates Colorectal Cancer Progression.

Carethers JM, Koi M, Tseng-Rogenski SS.

Genes (Basel). 2015 Mar 31;6(2):185-205. doi: 10.3390/genes6020185. Review.


Mammalian Exo1 encodes both structural and catalytic functions that play distinct roles in essential biological processes.

Schaetzlein S, Chahwan R, Avdievich E, Roa S, Wei K, Eoff RL, Sellers RS, Clark AB, Kunkel TA, Scharff MD, Edelmann W.

Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):E2470-9. doi: 10.1073/pnas.1308512110. Epub 2013 Jun 10.


Heterozygosity for p53 promotes microsatellite instability and tumorigenesis on a Msh2 deficient background.

Toft NJ, Curtis LJ, Sansom OJ, Leitch AL, Wyllie AH, te Riele H, Arends MJ, Clarke AR.

Oncogene. 2002 Sep 12;21(41):6299-306.


Synergistic interaction of Rnf8 and p53 in the protection against genomic instability and tumorigenesis.

Halaby MJ, Hakem A, Li L, El Ghamrasni S, Venkatesan S, Hande PM, Sanchez O, Hakem R.

PLoS Genet. 2013;9(1):e1003259. doi: 10.1371/journal.pgen.1003259. Epub 2013 Jan 31.


Distinct requirements within the Msh3 nucleotide binding pocket for mismatch and double-strand break repair.

Kumar C, Williams GM, Havens B, Dinicola MK, Surtees JA.

J Mol Biol. 2013 Jun 12;425(11):1881-98. doi: 10.1016/j.jmb.2013.02.024. Epub 2013 Feb 28.


Mouse models for hereditary nonpolyposis colorectal cancer.

de Wind N, Dekker M, van Rossum A, van der Valk M, te Riele H.

Cancer Res. 1998 Jan 15;58(2):248-55.


Schizosaccharomyces pombe MutSα and MutLα Maintain Stability of Tetra-Nucleotide Repeats and Msh3 of Hepta-Nucleotide Repeats.

Villahermosa D, Christensen O, Knapp K, Fleck O.

G3 (Bethesda). 2017 May 5;7(5):1463-1473. doi: 10.1534/g3.117.040816.


Spontaneous and mutagen-induced transformation of primary cultures of Msh2-/- p53-/- colonocytes.

Sevignani C, Cranston A, Iozzo RV, Fishel R, Calabretta B.

Cancer Res. 1999 Dec 1;59(23):5882-6.


DNA mismatch repair complex MutSβ promotes GAA·TTC repeat expansion in human cells.

Halabi A, Ditch S, Wang J, Grabczyk E.

J Biol Chem. 2012 Aug 24;287(35):29958-67. doi: 10.1074/jbc.M112.356758. Epub 2012 Jul 11.


MutSbeta exceeds MutSalpha in dinucleotide loop repair.

Kantelinen J, Kansikas M, Korhonen MK, Ollila S, Heinimann K, Kariola R, Nyström M.

Br J Cancer. 2010 Mar 16;102(6):1068-73. doi: 10.1038/sj.bjc.6605531. Epub 2010 Feb 16.


The mouse mismatch repair protein, MSH3, is a nucleoplasmic protein that aggregates into denser nuclear bodies under conditions of stress.

Holt I, Thanh Lam L, Tomé S, Wansink DG, Te Riele H, Gourdon G, Morris GE.

J Cell Biochem. 2011 Jun;112(6):1612-21. doi: 10.1002/jcb.23075.


(CAG)(n)-hairpin DNA binds to Msh2-Msh3 and changes properties of mismatch recognition.

Owen BA, Yang Z, Lai M, Gajec M, Badger JD 2nd, Hayes JJ, Edelmann W, Kucherlapati R, Wilson TM, McMurray CT.

Nat Struct Mol Biol. 2005 Aug;12(8):663-70. Epub 2005 Jul 17. Erratum in: Nat Struct Mol Biol. 2005 Sep;12(9):824. Gajek, Maciez [corrected to Gajec, Maciej].


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