Sort by

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 88


SLX4 assembles a telomere maintenance toolkit by bridging multiple endonucleases with telomeres.

Wan B, Yin J, Horvath K, Sarkar J, Chen Y, Wu J, Wan K, Lu J, Gu P, Yu EY, Lue NF, Chang S, Liu Y, Lei M.

Cell Rep. 2013 Sep 12;4(5):861-9. doi: 10.1016/j.celrep.2013.08.017.


SLX4 contributes to telomere preservation and regulated processing of telomeric joint molecule intermediates.

Sarkar J, Wan B, Yin J, Vallabhaneni H, Horvath K, Kulikowicz T, Bohr VA, Zhang Y, Lei M, Liu Y.

Nucleic Acids Res. 2015 Jul 13;43(12):5912-23. doi: 10.1093/nar/gkv522.


Localization-dependent and -independent roles of SLX4 in regulating telomeres.

Wilson JS, Tejera AM, Castor D, Toth R, Blasco MA, Rouse J.

Cell Rep. 2013 Sep 12;4(5):853-60. doi: 10.1016/j.celrep.2013.07.033.


Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair.

Svendsen JM, Smogorzewska A, Sowa ME, O'Connell BC, Gygi SP, Elledge SJ, Harper JW.

Cell. 2009 Jul 10;138(1):63-77. doi: 10.1016/j.cell.2009.06.030.


Human SLX4 is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases.

Fekairi S, Scaglione S, Chahwan C, Taylor ER, Tissier A, Coulon S, Dong MQ, Ruse C, Yates JR 3rd, Russell P, Fuchs RP, McGowan CH, Gaillard PH.

Cell. 2009 Jul 10;138(1):78-89. doi: 10.1016/j.cell.2009.06.029.


Coordination of structure-specific nucleases by human SLX4/BTBD12 is required for DNA repair.

Muñoz IM, Hain K, Déclais AC, Gardiner M, Toh GW, Sanchez-Pulido L, Heuckmann JM, Toth R, Macartney T, Eppink B, Kanaar R, Ponting CP, Lilley DM, Rouse J.

Mol Cell. 2009 Jul 10;35(1):116-27. doi: 10.1016/j.molcel.2009.06.020.


The basic N-terminal domain of TRF2 limits recombination endonuclease action at human telomeres.

Saint-Léger A, Koelblen M, Civitelli L, Bah A, Djerbi N, Giraud-Panis MJ, Londoño-Vallejo A, Ascenzioni F, Gilson E.

Cell Cycle. 2014;13(15):2469-74. doi: 10.4161/cc.29422.


ERCC1/XPF removes the 3' overhang from uncapped telomeres and represses formation of telomeric DNA-containing double minute chromosomes.

Zhu XD, Niedernhofer L, Kuster B, Mann M, Hoeijmakers JH, de Lange T.

Mol Cell. 2003 Dec;12(6):1489-98.


Human XPF controls TRF2 and telomere length maintenance through distinctive mechanisms.

Wu Y, Mitchell TR, Zhu XD.

Mech Ageing Dev. 2008 Oct;129(10):602-10. doi: 10.1016/j.mad.2008.08.004.


Human GEN1 and the SLX4-associated nucleases MUS81 and SLX1 are essential for the resolution of replication-induced Holliday junctions.

Garner E, Kim Y, Lach FP, Kottemann MC, Smogorzewska A.

Cell Rep. 2013 Oct 17;5(1):207-15. doi: 10.1016/j.celrep.2013.08.041.


Dimerization of SLX4 contributes to functioning of the SLX4-nuclease complex.

Yin J, Wan B, Sarkar J, Horvath K, Wu J, Chen Y, Cheng G, Wan K, Chin P, Lei M, Liu Y.

Nucleic Acids Res. 2016 Jun 2;44(10):4871-80. doi: 10.1093/nar/gkw354.


Coordinated actions of SLX1-SLX4 and MUS81-EME1 for Holliday junction resolution in human cells.

Wyatt HD, Sarbajna S, Matos J, West SC.

Mol Cell. 2013 Oct 24;52(2):234-47. doi: 10.1016/j.molcel.2013.08.035.


Involvement of SLX4 in interstrand cross-link repair is regulated by the Fanconi anemia pathway.

Yamamoto KN, Kobayashi S, Tsuda M, Kurumizaka H, Takata M, Kono K, Jiricny J, Takeda S, Hirota K.

Proc Natl Acad Sci U S A. 2011 Apr 19;108(16):6492-6. doi: 10.1073/pnas.1018487108.


Cooperative control of holliday junction resolution and DNA repair by the SLX1 and MUS81-EME1 nucleases.

Castor D, Nair N, Déclais AC, Lachaud C, Toth R, Macartney TJ, Lilley DM, Arthur JS, Rouse J.

Mol Cell. 2013 Oct 24;52(2):221-33. doi: 10.1016/j.molcel.2013.08.036.


Identification and characterization of MUS81 point mutations that abolish interaction with the SLX4 scaffold protein.

Nair N, Castor D, Macartney T, Rouse J.

DNA Repair (Amst). 2014 Dec;24:131-7. doi: 10.1016/j.dnarep.2014.08.004.


Noncovalent interactions with SUMO and ubiquitin orchestrate distinct functions of the SLX4 complex in genome maintenance.

Ouyang J, Garner E, Hallet A, Nguyen HD, Rickman KA, Gill G, Smogorzewska A, Zou L.

Mol Cell. 2015 Jan 8;57(1):108-22. doi: 10.1016/j.molcel.2014.11.015.


Structure and mechanism of nucleases regulated by SLX4.

Nowotny M, Gaur V.

Curr Opin Struct Biol. 2016 Feb;36:97-105. doi: 10.1016/ Review.


Disruption of SLX4-MUS81 Function Increases the Relative Biological Effectiveness of Proton Radiation.

Liu Q, Underwood TS, Kung J, Wang M, Lu HM, Paganetti H, Held KD, Hong TS, Efstathiou JA, Willers H.

Int J Radiat Oncol Biol Phys. 2016 May 1;95(1):78-85. doi: 10.1016/j.ijrobp.2016.01.046.


Regulation of multiple DNA repair pathways by the Fanconi anemia protein SLX4.

Kim Y, Spitz GS, Veturi U, Lach FP, Auerbach AD, Smogorzewska A.

Blood. 2013 Jan 3;121(1):54-63. doi: 10.1182/blood-2012-07-441212.

Items per page

Supplemental Content

Support Center