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Items: 1 to 20 of 101

1.

Nonpeptidic angiotensin II AT₁ receptor antagonists derived from 6-substituted aminocarbonyl and acylamino benzimidazoles.

Zhang J, Wang JL, Yu WF, Zhou ZM, Tao WC, Wang YC, Xue WZ, Xu D, Hao LP, Han XF, Fei F, Liu T, Liang AH.

Eur J Med Chem. 2013 Nov;69:44-54. doi: 10.1016/j.ejmech.2013.08.014. Epub 2013 Aug 19.

PMID:
24007859
2.

Design, synthesis and biological evaluation of 6-substituted aminocarbonyl benzimidazole derivatives as nonpeptidic angiotensin II AT1 receptor antagonists.

Wang JL, Zhang J, Zhou ZM, Li ZH, Xue WZ, Xu D, Hao LP, Han XF, Fei F, Liu T, Liang AH.

Eur J Med Chem. 2012 Mar;49:183-90. doi: 10.1016/j.ejmech.2012.01.009. Epub 2012 Jan 17.

PMID:
22309912
3.

Design, synthesis and biological activity of 6-substituted carbamoyl benzimidazoles as new nonpeptidic angiotensin II AT₁ receptor antagonists.

Zhang J, Wang JL, Zhou ZM, Li ZH, Xue WZ, Xu D, Hao LP, Han XF, Fei F, Liu T, Liang AH.

Bioorg Med Chem. 2012 Jul 15;20(14):4208-16. doi: 10.1016/j.bmc.2012.05.056. Epub 2012 Jun 5.

PMID:
22727371
4.

Discovery of novel, potent and low-toxicity angiotensin II receptor type 1 (AT1) blockers: Design, synthesis and biological evaluation of 6-substituted aminocarbonyl benzimidazoles with a chiral center.

Han XF, He X, Wang M, Xu D, Hao LP, Liang AH, Zhang J, Zhou ZM.

Eur J Med Chem. 2015 Oct 20;103:473-87. doi: 10.1016/j.ejmech.2015.09.010. Epub 2015 Sep 12.

PMID:
26397395
5.

Angiotensin II--AT1 receptor antagonists: design, synthesis and evaluation of substituted carboxamido benzimidazole derivatives.

Shah DI, Sharma M, Bansal Y, Bansal G, Singh M.

Eur J Med Chem. 2008 Sep;43(9):1808-12. Epub 2007 Nov 22.

PMID:
18158200
6.

6-Substituted benzimidazoles as new nonpeptide angiotensin II receptor antagonists: synthesis, biological activity, and structure-activity relationships.

Ries UJ, Mihm G, Narr B, Hasselbach KM, Wittneben H, Entzeroth M, van Meel JC, Wienen W, Hauel NH.

J Med Chem. 1993 Dec 10;36(25):4040-51.

PMID:
8258826
7.
8.

In vitro antagonistic properties of a new angiotensin type 1 receptor blocker, azilsartan, in receptor binding and function studies.

Ojima M, Igata H, Tanaka M, Sakamoto H, Kuroita T, Kohara Y, Kubo K, Fuse H, Imura Y, Kusumoto K, Nagaya H.

J Pharmacol Exp Ther. 2011 Mar;336(3):801-8. doi: 10.1124/jpet.110.176636. Epub 2010 Dec 1.

9.

3D QSAR studies on substituted benzimidazole derivatives as angiotensin II-AT1 receptor antagonist.

Vyas VK, Ghate M, Chintha C, Patel P.

Curr Comput Aided Drug Des. 2013 Sep;9(3):433-45.

PMID:
24010938
10.

Design, synthesis, and docking studies of novel benzimidazoles for the treatment of metabolic syndrome.

Mizuno CS, Chittiboyina AG, Shah FH, Patny A, Kurtz TW, Pershadsingh HA, Speth RC, Karamyan VT, Carvalho PB, Avery MA.

J Med Chem. 2010 Feb 11;53(3):1076-85. doi: 10.1021/jm901272d.

PMID:
20073471
11.

The discovery of new potent non-peptide Angiotensin II AT1 receptor blockers: a concise synthesis, molecular docking studies and biological evaluation of N-substituted 5-butylimidazole derivatives.

Agelis G, Resvani A, Durdagi S, Spyridaki K, Tůmová T, Slaninová J, Giannopoulos P, Vlahakos D, Liapakis G, Mavromoustakos T, Matsoukas J.

Eur J Med Chem. 2012 Sep;55:358-74. doi: 10.1016/j.ejmech.2012.07.040. Epub 2012 Jul 31.

PMID:
22889560
12.

Design, synthesis, and evaluation of imidazo[4,5-c]pyridin-4-one derivatives with dual activity at angiotensin II type 1 receptor and peroxisome proliferator-activated receptor-γ.

Casimiro-Garcia A, Heemstra RJ, Bigge CF, Chen J, Ciske FA, Davis JA, Ellis T, Esmaeil N, Flynn D, Han S, Jalaie M, Ohren JF, Powell NA.

Bioorg Med Chem Lett. 2013 Feb 1;23(3):767-72. doi: 10.1016/j.bmcl.2012.11.088. Epub 2012 Dec 1.

PMID:
23265881
13.
14.

Unique "delta lock" structure of telmisartan is involved in its strongest binding affinity to angiotensin II type 1 receptor.

Ohno K, Amano Y, Kakuta H, Niimi T, Takakura S, Orita M, Miyata K, Sakashita H, Takeuchi M, Komuro I, Higaki J, Horiuchi M, Kim-Mitsuyama S, Mori Y, Morishita R, Yamagishi S.

Biochem Biophys Res Commun. 2011 Jan 7;404(1):434-7. doi: 10.1016/j.bbrc.2010.11.139. Epub 2010 Dec 3.

PMID:
21130741
15.

Synthesis and biological activity of 2-alkylbenzimidazoles bearing a N-phenylpyrrole moiety as novel angiotensin II AT1 receptor antagonists.

Xu JY, Zeng Y, Ran Q, Wei Z, Bi Y, He QH, Wang QJ, Hu S, Zhang J, Tang MY, Hua WY, Wu XM.

Bioorg Med Chem Lett. 2007 May 15;17(10):2921-6. Epub 2007 Feb 20.

PMID:
17412584
16.

Design, synthesis, and evaluation of novelly substituted benzimidazole compounds as angiotensin II receptor antagonists.

Bali A, Bansal Y, Sugumaran M, Saggu JS, Balakumar P, Kaur G, Bansal G, Sharma A, Singh M.

Bioorg Med Chem Lett. 2005 Sep 1;15(17):3962-5.

PMID:
16039125
17.

Substituted benzimidazole derivatives as angiotensin II-AT1 receptor antagonist: a review.

Vyas VK, Ghate M.

Mini Rev Med Chem. 2010 Dec;10(14):1366-84. Review.

PMID:
20937029
18.

Molecular characterisation of the interactions between olmesartan and telmisartan and the human angiotensin II AT1 receptor.

Le MT, Pugsley MK, Vauquelin G, Van Liefde I.

Br J Pharmacol. 2007 Aug;151(7):952-62. Epub 2007 Jun 18.

19.

Design, synthesis and biological evaluation of new 5-nitro benzimidazole derivatives as AT1 antagonists with anti-hypertension activities.

Zhu W, Da Y, Wu D, Zheng H, Zhu L, Wang L, Yan Y, Chen Z.

Bioorg Med Chem. 2014 Apr 1;22(7):2294-302. doi: 10.1016/j.bmc.2014.02.008. Epub 2014 Feb 18.

PMID:
24613628
20.

Synthesis and biological evaluation of novel potent angiotensin II receptor antagonists with anti-hypertension effect.

Nie YY, Da YJ, Zheng H, Yang XX, Jia L, Wen CH, Liang LS, Tian J, Chen ZL.

Bioorg Med Chem. 2012 Apr 15;20(8):2747-61. doi: 10.1016/j.bmc.2012.02.003. Epub 2012 Feb 11.

PMID:
22410249

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