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Investigating Myc-dependent translational regulation in normal and cancer cells.

Cunningham JT, Pourdehnad M, Stumpf CR, Ruggero D.

Methods Mol Biol. 2013;1012:201-12. doi: 10.1007/978-1-62703-429-6_13.


Translation initiation by the c-myc mRNA internal ribosome entry sequence and the poly(A) tail.

Thoma C, Fraterman S, Gentzel M, Wilm M, Hentze MW.

RNA. 2008 Aug;14(8):1579-89. doi: 10.1261/rna.1043908. Epub 2008 Jun 12.


Myc up-regulates formation of the mRNA methyl cap.

Cowling VH.

Biochem Soc Trans. 2010 Dec;38(6):1598-601. doi: 10.1042/BST0381598.


Analysis of the c-myc IRES; a potential role for cell-type specific trans-acting factors and the nuclear compartment.

Stoneley M, Subkhankulova T, Le Quesne JP, Coldwell MJ, Jopling CL, Belsham GJ, Willis AE.

Nucleic Acids Res. 2000 Feb 1;28(3):687-94.


Eukaryotic translation initiation factor 4GI and p97 promote cellular internal ribosome entry sequence-driven translation.

Hundsdoerfer P, Thoma C, Hentze MW.

Proc Natl Acad Sci U S A. 2005 Sep 20;102(38):13421-6. Epub 2005 Sep 7.


Transcription-independent functions of MYC: regulation of translation and DNA replication.

Cole MD, Cowling VH.

Nat Rev Mol Cell Biol. 2008 Oct;9(10):810-5. doi: 10.1038/nrm2467. Epub 2008 Aug 13. Review.


The role of c-myc in regulation of translation initiation.

Schmidt EV.

Oncogene. 2004 Apr 19;23(18):3217-21. Review.


S-adenosyl homocysteine hydrolase is required for Myc-induced mRNA cap methylation, protein synthesis, and cell proliferation.

Fernandez-Sanchez ME, Gonatopoulos-Pournatzis T, Preston G, Lawlor MA, Cowling VH.

Mol Cell Biol. 2009 Dec;29(23):6182-91. doi: 10.1128/MCB.00973-09. Epub 2009 Oct 5.


eIF4E activity is regulated at multiple levels.

Raught B, Gingras AC.

Int J Biochem Cell Biol. 1999 Jan;31(1):43-57. Review.


Internal ribosome entry segment-mediated initiation of c-Myc protein synthesis following genotoxic stress.

Subkhankulova T, Mitchell SA, Willis AE.

Biochem J. 2001 Oct 1;359(Pt 1):183-92.


An essential E box in the promoter of the gene encoding the mRNA cap-binding protein (eukaryotic initiation factor 4E) is a target for activation by c-myc.

Jones RM, Branda J, Johnston KA, Polymenis M, Gadd M, Rustgi A, Callanan L, Schmidt EV.

Mol Cell Biol. 1996 Sep;16(9):4754-64.


Canonical initiation factor requirements of the Myc family of internal ribosome entry segments.

Spriggs KA, Cobbold LC, Jopling CL, Cooper RE, Wilson LA, Stoneley M, Coldwell MJ, Poncet D, Shen YC, Morley SJ, Bushell M, Willis AE.

Mol Cell Biol. 2009 Mar;29(6):1565-74. doi: 10.1128/MCB.01283-08. Epub 2009 Jan 5.


Transcriptional regulation of BRD7 expression by Sp1 and c-Myc.

Liu H, Zhou M, Luo X, Zhang L, Niu Z, Peng C, Ma J, Peng S, Zhou H, Xiang B, Li X, Li S, He J, Li X, Li G.

BMC Mol Biol. 2008 Dec 27;9:111. doi: 10.1186/1471-2199-9-111.


c-Myc affects mRNA translation, cell proliferation and progenitor cell function in the mammary gland.

Stoelzle T, Schwarb P, Trumpp A, Hynes NE.

BMC Biol. 2009 Sep 28;7:63. doi: 10.1186/1741-7007-7-63.


c-myc Repression of TSC2 contributes to control of translation initiation and Myc-induced transformation.

Ravitz MJ, Chen L, Lynch M, Schmidt EV.

Cancer Res. 2007 Dec 1;67(23):11209-17.

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