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Evaluation of cancer dependence and druggability of PRP4 kinase using cellular, biochemical, and structural approaches.

Gao Q, Mechin I, Kothari N, Guo Z, Deng G, Haas K, McManus J, Hoffmann D, Wang A, Wiederschain D, Rocnik J, Czechtizky W, Chen X, McLean L, Arlt H, Harper D, Liu F, Majid T, Patel V, Lengauer C, Garcia-Echeverria C, Zhang B, Cheng H, Dorsch M, Huang SM.

J Biol Chem. 2013 Oct 18;288(42):30125-38. doi: 10.1074/jbc.M113.473348. Epub 2013 Sep 3.


Functional and structural characterization of the prp3 binding domain of the yeast prp4 splicing factor.

Ayadi L, Callebaut I, Saguez C, Villa T, Mornon JP, Banroques J.

J Mol Biol. 1998 Dec 4;284(3):673-87.


Functional analysis of the fission yeast Prp4 protein kinase involved in pre-mRNA splicing and isolation of a putative mammalian homologue.

Gross T, Lützelberger M, Weigmann H, Klingenhoff A, Shenoy S, Käufer NF.

Nucleic Acids Res. 1997 Mar 1;25(5):1028-35.


Mutational analysis of the PRP4 protein of Saccharomyces cerevisiae suggests domain structure and snRNP interactions.

Hu J, Xu Y, Schappert K, Harrington T, Wang A, Braga R, Mogridge J, Friesen JD.

Nucleic Acids Res. 1994 May 11;22(9):1724-34.


Extragenic suppressors of Saccharomyces cerevisiae prp4 mutations identify a negative regulator of PRP genes.

Maddock JR, Weidenhammer EM, Adams CC, Lunz RL, Woolford JL Jr.

Genetics. 1994 Mar;136(3):833-47.


Cloning of human PRP4 reveals interaction with Clk1.

Kojima T, Zama T, Wada K, Onogi H, Hagiwara M.

J Biol Chem. 2001 Aug 24;276(34):32247-56. Epub 2001 Jun 19.


Prp4 Kinase Grants the License to Splice: Control of Weak Splice Sites during Spliceosome Activation.

Eckert D, Andrée N, Razanau A, Zock-Emmenthal S, Lützelberger M, Plath S, Schmidt H, Guerra-Moreno A, Cozzuto L, Ayté J, Käufer NF.

PLoS Genet. 2016 Jan 5;12(1):e1005768. doi: 10.1371/journal.pgen.1005768. eCollection 2016 Jan.


Interaction of PRP4 with Kruppel-like factor 13 regulates CCL5 transcription.

Huang B, Ahn YT, McPherson L, Clayberger C, Krensky AM.

J Immunol. 2007 Jun 1;178(11):7081-7.


PRP4: a protein of the yeast U4/U6 small nuclear ribonucleoprotein particle.

Banroques J, Abelson JN.

Mol Cell Biol. 1989 Sep;9(9):3710-9.


Mammalian PRP4 kinase copurifies and interacts with components of both the U5 snRNP and the N-CoR deacetylase complexes.

Dellaire G, Makarov EM, Cowger JJ, Longman D, Sutherland HG, Lührmann R, Torchia J, Bickmore WA.

Mol Cell Biol. 2002 Jul;22(14):5141-56.


A composite double-/single-stranded RNA-binding region in protein Prp3 supports tri-snRNP stability and splicing.

Liu S, Mozaffari-Jovin S, Wollenhaupt J, Santos KF, Theuser M, Dunin-Horkawicz S, Fabrizio P, Bujnicki JM, Lührmann R, Wahl MC.

Elife. 2015 Jul 10;4:e07320. doi: 10.7554/eLife.07320.


Genetic and pharmacological inhibition of PDK1 in cancer cells: characterization of a selective allosteric kinase inhibitor.

Nagashima K, Shumway SD, Sathyanarayanan S, Chen AH, Dolinski B, Xu Y, Keilhack H, Nguyen T, Wiznerowicz M, Li L, Lutterbach BA, Chi A, Paweletz C, Allison T, Yan Y, Munshi SK, Klippel A, Kraus M, Bobkova EV, Deshmukh S, Xu Z, Mueller U, Szewczak AA, Pan BS, Richon V, Pollock R, Blume-Jensen P, Northrup A, Andersen JN.

J Biol Chem. 2011 Feb 25;286(8):6433-48. doi: 10.1074/jbc.M110.156463. Epub 2010 Nov 30.


PRP4 is a spindle assembly checkpoint protein required for MPS1, MAD1, and MAD2 localization to the kinetochores.

Montembault E, Dutertre S, Prigent C, Giet R.

J Cell Biol. 2007 Nov 19;179(4):601-9. Epub 2007 Nov 12.

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