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Multiple checkpoint breach of B cell tolerance in Rasgrp1-deficient mice.

Bartlett A, Buhlmann JE, Stone J, Lim B, Barrington RA.

J Immunol. 2013 Oct 1;191(7):3605-13. doi: 10.4049/jimmunol.1202892. Epub 2013 Aug 30.


CD275-Independent IL-17-Producing T Follicular Helper-like Cells in Lymphopenic Autoimmune-Prone Mice.

Smith C, Buhlmann JE, Wang X, Bartlett A, Lim B, Barrington RA.

J Immunol. 2016 Jun 15;196(12):4935-46. doi: 10.4049/jimmunol.1402193. Epub 2016 May 16.


Chronic immunodeficiency in mice lacking RasGRP1 results in CD4 T cell immune activation and exhaustion.

Priatel JJ, Chen X, Zenewicz LA, Shen H, Harder KW, Horwitz MS, Teh HS.

J Immunol. 2007 Aug 15;179(4):2143-52.


The role of RasGRPs in regulation of lymphocyte proliferation.

Coughlin JJ, Stang SL, Dower NA, Stone JC.

Immunol Lett. 2006 May 15;105(1):77-82. Epub 2006 Feb 20.


Preferential development of CD4 and CD8 T regulatory cells in RasGRP1-deficient mice.

Chen X, Priatel JJ, Chow MT, Teh HS.

J Immunol. 2008 May 1;180(9):5973-82.


Loss of the proapoptotic protein, Bim, breaks B cell anergy.

Oliver PM, Vass T, Kappler J, Marrack P.

J Exp Med. 2006 Mar 20;203(3):731-41. Epub 2006 Mar 6.


The microRNA miR-148a functions as a critical regulator of B cell tolerance and autoimmunity.

Gonzalez-Martin A, Adams BD, Lai M, Shepherd J, Salvador-Bernaldez M, Salvador JM, Lu J, Nemazee D, Xiao C.

Nat Immunol. 2016 Apr;17(4):433-40. doi: 10.1038/ni.3385. Epub 2016 Feb 22.


Signaling lymphocytic activation molecule (SLAM)/SLAM-associated protein pathway regulates human B-cell tolerance.

Menard L, Cantaert T, Chamberlain N, Tangye SG, Riminton S, Church JA, Klion A, Cunningham-Rundles C, Nichols KE, Meffre E.

J Allergy Clin Immunol. 2014 Apr;133(4):1149-61. doi: 10.1016/j.jaci.2013.10.051. Epub 2013 Dec 25.


RasGRP1 and RasGRP3 regulate B cell proliferation by facilitating B cell receptor-Ras signaling.

Coughlin JJ, Stang SL, Dower NA, Stone JC.

J Immunol. 2005 Dec 1;175(11):7179-84.


Loss of the pro-apoptotic BH3-only Bcl-2 family member Bim sustains B lymphopoiesis in the absence of IL-7.

Huntington ND, Labi V, Cumano A, Vieira P, Strasser A, Villunger A, Di Santo JP, Alves NL.

Int Immunol. 2009 Jun;21(6):715-25. doi: 10.1093/intimm/dxp043. Epub 2009 May 19.


Cell-intrinsic expression of TLR9 in autoreactive B cells constrains BCR/TLR7-dependent responses.

Nündel K, Green NM, Shaffer AL, Moody KL, Busto P, Eilat D, Miyake K, Oropallo MA, Cancro MP, Marshak-Rothstein A.

J Immunol. 2015 Mar 15;194(6):2504-12. doi: 10.4049/jimmunol.1402425. Epub 2015 Feb 13.


Critical roles of Bim in T cell activation and T cell-mediated autoimmune inflammation in mice.

Ludwinski MW, Sun J, Hilliard B, Gong S, Xue F, Carmody RJ, DeVirgiliis J, Chen YH.

J Clin Invest. 2009 Jun;119(6):1706-13. doi: 10.1172/JCI37619.


B cell-intrinsic TLR7 signaling is essential for the development of spontaneous germinal centers.

Soni C, Wong EB, Domeier PP, Khan TN, Satoh T, Akira S, Rahman ZS.

J Immunol. 2014 Nov 1;193(9):4400-14. doi: 10.4049/jimmunol.1401720. Epub 2014 Sep 24.


Deletion of WASp and N-WASp in B cells cripples the germinal center response and results in production of IgM autoantibodies.

Dahlberg CI, Torres ML, Petersen SH, Baptista MA, Keszei M, Volpi S, Grasset EK, Karlsson MC, Walter JE, Snapper SB, Notarangelo LD, Westerberg LS.

J Autoimmun. 2015 Aug;62:81-92. doi: 10.1016/j.jaut.2015.06.003. Epub 2015 Jul 2.


Enforced expression of the apoptosis inhibitor Bcl-2 ablates tolerance induction in DNA-reactive B cells through a novel mechanism.

Wang YH, Yan Y, Rice JS, Volpe BT, Diamond B.

J Autoimmun. 2011 Aug;37(1):18-27. doi: 10.1016/j.jaut.2011.03.002. Epub 2011 Apr 1.


Autoimmunity as the consequence of a spontaneous mutation in Rasgrp1.

Layer K, Lin G, Nencioni A, Hu W, Schmucker A, Antov AN, Li X, Takamatsu S, Chevassut T, Dower NA, Stang SL, Beier D, Buhlmann J, Bronson RT, Elkon KB, Stone JC, Van Parijs L, Lim B.

Immunity. 2003 Aug;19(2):243-55. Retraction in: Immunity. 2012 May 25;36(5):886.


Differential requirement of RasGRP1 for γδ T cell development and activation.

Chen Y, Ci X, Gorentla B, Sullivan SA, Stone JC, Zhang W, Pereira P, Lu J, Zhong XP.

J Immunol. 2012 Jul 1;189(1):61-71. doi: 10.4049/jimmunol.1103272. Epub 2012 May 23.


G alpha q-containing G proteins regulate B cell selection and survival and are required to prevent B cell-dependent autoimmunity.

Misra RS, Shi G, Moreno-Garcia ME, Thankappan A, Tighe M, Mousseau B, Kusser K, Becker-Herman S, Hudkins KL, Dunn R, Kehry MR, Migone TS, Marshak-Rothstein A, Simon M, Randall TD, Alpers CE, Liggitt D, Rawlings DJ, Lund FE.

J Exp Med. 2010 Aug 2;207(8):1775-89. doi: 10.1084/jem.20092735. Epub 2010 Jul 12.


Dedicator of cytokinesis 8-deficient patients have a breakdown in peripheral B-cell tolerance and defective regulatory T cells.

Janssen E, Morbach H, Ullas S, Bannock JM, Massad C, Menard L, Barlan I, Lefranc G, Su H, Dasouki M, Al-Herz W, Keles S, Chatila T, Geha RS, Meffre E.

J Allergy Clin Immunol. 2014 Dec;134(6):1365-74. doi: 10.1016/j.jaci.2014.07.042. Epub 2014 Sep 11.


The BH3-only proteins Bim and Puma cooperate to impose deletional tolerance of organ-specific antigens.

Gray DH, Kupresanin F, Berzins SP, Herold MJ, O'Reilly LA, Bouillet P, Strasser A.

Immunity. 2012 Sep 21;37(3):451-62. doi: 10.1016/j.immuni.2012.05.030. Epub 2012 Sep 6.

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