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Items: 1 to 20 of 104

1.

Second-generation minimal physiologically-based pharmacokinetic model for monoclonal antibodies.

Cao Y, Balthasar JP, Jusko WJ.

J Pharmacokinet Pharmacodyn. 2013 Oct;40(5):597-607. doi: 10.1007/s10928-013-9332-2. Epub 2013 Aug 31.

2.

Survey of monoclonal antibody disposition in man utilizing a minimal physiologically-based pharmacokinetic model.

Cao Y, Jusko WJ.

J Pharmacokinet Pharmacodyn. 2014 Dec;41(6):571-80. doi: 10.1007/s10928-014-9374-0. Epub 2014 Aug 22.

3.

Across-Species Scaling of Monoclonal Antibody Pharmacokinetics Using a Minimal PBPK Model.

Zhao J, Cao Y, Jusko WJ.

Pharm Res. 2015 Oct;32(10):3269-81. doi: 10.1007/s11095-015-1703-5. Epub 2015 May 5.

4.

Towards a platform PBPK model to characterize the plasma and tissue disposition of monoclonal antibodies in preclinical species and human.

Shah DK, Betts AM.

J Pharmacokinet Pharmacodyn. 2012 Feb;39(1):67-86. doi: 10.1007/s10928-011-9232-2. Epub 2011 Dec 6.

PMID:
22143261
5.

Incorporating target-mediated drug disposition in a minimal physiologically-based pharmacokinetic model for monoclonal antibodies.

Cao Y, Jusko WJ.

J Pharmacokinet Pharmacodyn. 2014 Aug;41(4):375-87. doi: 10.1007/s10928-014-9372-2. Epub 2014 Jul 31.

6.

Applications of minimal physiologically-based pharmacokinetic models.

Cao Y, Jusko WJ.

J Pharmacokinet Pharmacodyn. 2012 Dec;39(6):711-23. doi: 10.1007/s10928-012-9280-2. Epub 2012 Nov 23.

7.
8.

Physiologically-based pharmacokinetic (PBPK) model to predict IgG tissue kinetics in wild-type and FcRn-knockout mice.

Garg A, Balthasar JP.

J Pharmacokinet Pharmacodyn. 2007 Oct;34(5):687-709. Epub 2007 Jul 18.

PMID:
17636457
9.

Monoclonal antibody disposition: a simplified PBPK model and its implications for the derivation and interpretation of classical compartment models.

Fronton L, Pilari S, Huisinga W.

J Pharmacokinet Pharmacodyn. 2014 Apr;41(2):87-107. doi: 10.1007/s10928-014-9349-1. Epub 2014 Feb 4.

PMID:
24493102
10.

Scale-up of a physiologically-based pharmacokinetic model to predict the disposition of monoclonal antibodies in monkeys.

Glassman PM, Chen Y, Balthasar JP.

J Pharmacokinet Pharmacodyn. 2015 Oct;42(5):527-40. doi: 10.1007/s10928-015-9444-y. Epub 2015 Sep 12.

PMID:
26364301
11.

Application of PBPK modeling to predict monoclonal antibody disposition in plasma and tissues in mouse models of human colorectal cancer.

Abuqayyas L, Balthasar JP.

J Pharmacokinet Pharmacodyn. 2012 Dec;39(6):683-710. doi: 10.1007/s10928-012-9279-8. Epub 2012 Nov 27.

12.

Simplification of complex physiologically based pharmacokinetic models of monoclonal antibodies.

Elmeliegy M, Lowe P, Krzyzanski W.

AAPS J. 2014 Jul;16(4):810-42. doi: 10.1208/s12248-014-9591-x. Epub 2014 May 29.

13.

Interstitial IgG antibody pharmacokinetics assessed by combined in vivo- and physiologically-based pharmacokinetic modelling approaches.

Eigenmann MJ, Karlsen TV, Krippendorff BF, Tenstad O, Fronton L, Otteneder MB, Wiig H.

J Physiol. 2017 Dec 15;595(24):7311-7330. doi: 10.1113/JP274819. Epub 2017 Oct 29.

PMID:
28960303
14.

Physiologically-based pharmacokinetic modeling to predict the clinical pharmacokinetics of monoclonal antibodies.

Glassman PM, Balthasar JP.

J Pharmacokinet Pharmacodyn. 2016 Aug;43(4):427-46. doi: 10.1007/s10928-016-9482-0. Epub 2016 Jul 4.

PMID:
27377311
15.

Predicting the effects of 8C2, a monoclonal anti-topotecan antibody, on plasma and tissue disposition of topotecan.

Shah DK, Balthasar JP.

J Pharmacokinet Pharmacodyn. 2014 Feb;41(1):55-69. doi: 10.1007/s10928-013-9346-9. Epub 2013 Dec 25.

16.

Simulation of monoclonal antibody pharmacokinetics in humans using a minimal physiologically based model.

Li L, Gardner I, Dostalek M, Jamei M.

AAPS J. 2014 Sep;16(5):1097-109. doi: 10.1208/s12248-014-9640-5. Epub 2014 Jul 9.

18.

Evaluation of near infrared fluorescent labeling of monoclonal antibodies as a tool for tissue distribution.

Conner KP, Rock BM, Kwon GK, Balthasar JP, Abuqayyas L, Wienkers LC, Rock DA.

Drug Metab Dispos. 2014 Nov;42(11):1906-13. doi: 10.1124/dmd.114.060319. Epub 2014 Sep 10. Erratum in: Drug Metab Dispos. 2015 Jan;43(1):53.

19.

Predicted and observed effects of antibody affinity and antigen density on monoclonal antibody uptake in solid tumors.

Sung C, Shockley TR, Morrison PF, Dvorak HF, Yarmush ML, Dedrick RL.

Cancer Res. 1992 Jan 15;52(2):377-84.

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