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Items: 1 to 20 of 92

1.

Open-channel structures of the human glycine receptor α1 full-length transmembrane domain.

Mowrey DD, Cui T, Jia Y, Ma D, Makhov AM, Zhang P, Tang P, Xu Y.

Structure. 2013 Oct 8;21(10):1897-904. doi: 10.1016/j.str.2013.07.014. Epub 2013 Aug 29.

2.

Correlating structural and energetic changes in glycine receptor activation.

Scott S, Lynch JW, Keramidas A.

J Biol Chem. 2015 Feb 27;290(9):5621-34. doi: 10.1074/jbc.M114.616573. Epub 2015 Jan 8.

3.
5.

Glycine receptor mechanism elucidated by electron cryo-microscopy.

Du J, Lü W, Wu S, Cheng Y, Gouaux E.

Nature. 2015 Oct 8;526(7572):224-9. doi: 10.1038/nature14853. Epub 2015 Sep 7.

6.

Ensemble-based virtual screening for cannabinoid-like potentiators of the human glycine receptor α1 for the treatment of pain.

Wells MM, Tillman TS, Mowrey DD, Sun T, Xu Y, Tang P.

J Med Chem. 2015 Apr 9;58(7):2958-2966. doi: 10.1021/jm501873p. Epub 2015 Mar 27.

7.

Structure and dynamics of the second and third transmembrane domains of human glycine receptor.

Ma D, Liu Z, Li L, Tang P, Xu Y.

Biochemistry. 2005 Jun 21;44(24):8790-800.

PMID:
15952785
8.

Analysis of hyperekplexia mutations identifies transmembrane domain rearrangements that mediate glycine receptor activation.

Bode A, Lynch JW.

J Biol Chem. 2013 Nov 22;288(47):33760-71. doi: 10.1074/jbc.M113.513804. Epub 2013 Oct 4.

9.

Ethanol Modulation is Quantitatively Determined by the Transmembrane Domain of Human α1 Glycine Receptors.

Horani S, Stater EP, Corringer PJ, Trudell JR, Harris RA, Howard RJ.

Alcohol Clin Exp Res. 2015 Jun;39(6):962-8. doi: 10.1111/acer.12735. Epub 2015 May 14.

10.

Intermediate closed state for glycine receptor function revealed by cysteine cross-linking.

Prevost MS, Moraga-Cid G, Van Renterghem C, Edelstein SJ, Changeux JP, Corringer PJ.

Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):17113-8. doi: 10.1073/pnas.1317009110. Epub 2013 Oct 1.

11.

Contributions of conserved residues at the gating interface of glycine receptors.

Pless SA, Leung AW, Galpin JD, Ahern CA.

J Biol Chem. 2011 Oct 7;286(40):35129-36. doi: 10.1074/jbc.M111.269027. Epub 2011 Aug 11.

12.

Roles for loop 2 residues of alpha1 glycine receptors in agonist activation.

Crawford DK, Perkins DI, Trudell JR, Bertaccini EJ, Davies DL, Alkana RL.

J Biol Chem. 2008 Oct 10;283(41):27698-706. doi: 10.1074/jbc.M802384200. Epub 2008 Jul 25.

13.

Evidence for α-helices in the large intracellular domain mediating modulation of the α1-glycine receptor by ethanol and Gβγ.

Burgos CF, Castro PA, Mariqueo T, Bunster M, Guzmán L, Aguayo LG.

J Pharmacol Exp Ther. 2015 Jan;352(1):148-55. doi: 10.1124/jpet.114.217976. Epub 2014 Oct 22. Erratum in: J Pharmacol Exp Ther. 2015 Feb;352(2):325.

14.

A gating mechanism of pentameric ligand-gated ion channels.

Calimet N, Simoes M, Changeux JP, Karplus M, Taly A, Cecchini M.

Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):E3987-96. doi: 10.1073/pnas.1313785110. Epub 2013 Sep 16. Review.

15.

Effects of a mutation in the TM2-TM3 linker region of the glycine receptor alpha1 subunit on gating and allosteric modulation.

Dupre ML, Broyles JM, Mihic SJ.

Brain Res. 2007 Jun 4;1152:1-9. Epub 2007 Mar 15.

PMID:
17434460
16.
17.

A recombinant glycine receptor fragment forms homo-oligomers distinct from its GABA(A) counterpart.

Xue H, Shi H, Tsang SY, Zheng H, Savva CG, Sun J, Holzenburg A.

J Mol Biol. 2001 Oct 5;312(5):915-20.

PMID:
11580237
18.

The relative orientation of the TM3 and TM4 domains varies between α1 and α3 glycine receptors.

Han L, Talwar S, Lynch JW.

ACS Chem Neurosci. 2013 Feb 20;4(2):248-54. doi: 10.1021/cn300177g. Epub 2012 Nov 28.

19.

Functional prokaryotic-eukaryotic chimera from the pentameric ligand-gated ion channel family.

Duret G, Van Renterghem C, Weng Y, Prevost M, Moraga-Cid G, Huon C, Sonner JM, Corringer PJ.

Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):12143-8. doi: 10.1073/pnas.1104494108. Epub 2011 Jul 5.

20.

Structure and Pharmacologic Modulation of Inhibitory Glycine Receptors.

Burgos CF, Yévenes GE, Aguayo LG.

Mol Pharmacol. 2016 Sep;90(3):318-25. doi: 10.1124/mol.116.105726. Epub 2016 Jul 11. Review.

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