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Items: 1 to 20 of 115

1.

Calmodulin modulates the termination threshold for cardiac ryanodine receptor-mediated Ca2+ release.

Tian X, Tang Y, Liu Y, Wang R, Chen SR.

Biochem J. 2013 Nov 1;455(3):367-75. doi: 10.1042/BJ20130805. Erratum in: Biochem J. 2013 Dec 15;456(3):475.

PMID:
23992453
2.

Arrhythmogenic Calmodulin Mutations Affect the Activation and Termination of Cardiac Ryanodine Receptor-mediated Ca2+ Release.

Søndergaard MT, Tian X, Liu Y, Wang R, Chazin WJ, Chen SR, Overgaard MT.

J Biol Chem. 2015 Oct 23;290(43):26151-62. doi: 10.1074/jbc.M115.676627. Epub 2015 Aug 26.

3.

Molecular basis of calmodulin binding to cardiac muscle Ca(2+) release channel (ryanodine receptor).

Yamaguchi N, Xu L, Pasek DA, Evans KE, Meissner G.

J Biol Chem. 2003 Jun 27;278(26):23480-6. Epub 2003 Apr 21.

4.

The Arrhythmogenic Calmodulin p.Phe142Leu Mutation Impairs C-domain Ca2+ Binding but Not Calmodulin-dependent Inhibition of the Cardiac Ryanodine Receptor.

Søndergaard MT, Liu Y, Larsen KT, Nani A, Tian X, Holt C, Wang R, Wimmer R, Van Petegem F, Fill M, Chen SR, Overgaard MT.

J Biol Chem. 2017 Jan 27;292(4):1385-1395. doi: 10.1074/jbc.M116.766253. Epub 2016 Dec 7.

5.

Abnormal termination of Ca2+ release is a common defect of RyR2 mutations associated with cardiomyopathies.

Tang Y, Tian X, Wang R, Fill M, Chen SR.

Circ Res. 2012 Mar 30;110(7):968-77. doi: 10.1161/CIRCRESAHA.111.256560. Epub 2012 Feb 28.

6.

Role of Cys³⁶⁰² in the function and regulation of the cardiac ryanodine receptor.

Mi T, Xiao Z, Guo W, Tang Y, Hiess F, Xiao J, Wang Y, Zhang JZ, Zhang L, Wang R, Jones PP, Chen SR.

Biochem J. 2015 Apr 1;467(1):177-90. doi: 10.1042/BJ20141263.

PMID:
25605235
7.

Divergent regulation of ryanodine receptor 2 calcium release channels by arrhythmogenic human calmodulin missense mutants.

Hwang HS, Nitu FR, Yang Y, Walweel K, Pereira L, Johnson CN, Faggioni M, Chazin WJ, Laver D, George AL Jr, Cornea RL, Bers DM, Knollmann BC.

Circ Res. 2014 Mar 28;114(7):1114-24. doi: 10.1161/CIRCRESAHA.114.303391. Epub 2014 Feb 21.

8.

Cardiac calcium signalling pathologies associated with defective calmodulin regulation of type 2 ryanodine receptor.

Arnáiz-Cot JJ, Damon BJ, Zhang XH, Cleemann L, Yamaguchi N, Meissner G, Morad M.

J Physiol. 2013 Sep 1;591(17):4287-99. doi: 10.1113/jphysiol.2013.256123. Epub 2013 Jul 8.

9.

Regulation of the RYR1 and RYR2 Ca2+ release channel isoforms by Ca2+-insensitive mutants of calmodulin.

Fruen BR, Black DJ, Bloomquist RA, Bardy JM, Johnson JD, Louis CF, Balog EM.

Biochemistry. 2003 Mar 11;42(9):2740-7.

PMID:
12614169
11.

Cardiac hypertrophy associated with impaired regulation of cardiac ryanodine receptor by calmodulin and S100A1.

Yamaguchi N, Chakraborty A, Huang TQ, Xu L, Gomez AC, Pasek DA, Meissner G.

Am J Physiol Heart Circ Physiol. 2013 Jul 1;305(1):H86-94. doi: 10.1152/ajpheart.00144.2013. Epub 2013 May 10.

12.

The EF-hand Ca2+ Binding Domain Is Not Required for Cytosolic Ca2+ Activation of the Cardiac Ryanodine Receptor.

Guo W, Sun B, Xiao Z, Liu Y, Wang Y, Zhang L, Wang R, Chen SR.

J Biol Chem. 2016 Jan 29;291(5):2150-60. doi: 10.1074/jbc.M115.693325. Epub 2015 Dec 9.

13.

Caffeine induces Ca2+ release by reducing the threshold for luminal Ca2+ activation of the ryanodine receptor.

Kong H, Jones PP, Koop A, Zhang L, Duff HJ, Chen SR.

Biochem J. 2008 Sep 15;414(3):441-52. doi: 10.1042/BJ20080489.

14.

The CPVT-associated RyR2 mutation G230C enhances store overload-induced Ca2+ release and destabilizes the N-terminal domains.

Liu Y, Kimlicka L, Hiess F, Tian X, Wang R, Zhang L, Jones PP, Van Petegem F, Chen SR.

Biochem J. 2013 Aug 15;454(1):123-31. doi: 10.1042/BJ20130594.

PMID:
23746327
15.

Cardiac myocyte Z-line calmodulin is mainly RyR2-bound, and reduction is arrhythmogenic and occurs in heart failure.

Yang Y, Guo T, Oda T, Chakraborty A, Chen L, Uchinoumi H, Knowlton AA, Fruen BR, Cornea RL, Meissner G, Bers DM.

Circ Res. 2014 Jan 17;114(2):295-306. doi: 10.1161/CIRCRESAHA.114.302857. Epub 2013 Nov 1.

16.

FRET detection of calmodulin binding to the cardiac RyR2 calcium release channel.

Guo T, Fruen BR, Nitu FR, Nguyen TD, Yang Y, Cornea RL, Bers DM.

Biophys J. 2011 Nov 2;101(9):2170-7. doi: 10.1016/j.bpj.2011.09.030. Epub 2011 Nov 1.

17.

Defective calmodulin binding to the cardiac ryanodine receptor plays a key role in CPVT-associated channel dysfunction.

Xu X, Yano M, Uchinoumi H, Hino A, Suetomi T, Ono M, Tateishi H, Oda T, Okuda S, Doi M, Kobayashi S, Yamamoto T, Ikeda Y, Ikemoto N, Matsuzaki M.

Biochem Biophys Res Commun. 2010 Apr 9;394(3):660-6. doi: 10.1016/j.bbrc.2010.03.046. Epub 2010 Mar 10.

18.

Altered RyR2 regulation by the calmodulin F90L mutation associated with idiopathic ventricular fibrillation and early sudden cardiac death.

Nomikos M, Thanassoulas A, Beck K, Vassilakopoulou V, Hu H, Calver BL, Theodoridou M, Kashir J, Blayney L, Livaniou E, Rizkallah P, Nounesis G, Lai FA.

FEBS Lett. 2014 Aug 25;588(17):2898-902. doi: 10.1016/j.febslet.2014.07.007. Epub 2014 Jul 15.

19.

Dissociation of calmodulin from cardiac ryanodine receptor causes aberrant Ca(2+) release in heart failure.

Ono M, Yano M, Hino A, Suetomi T, Xu X, Susa T, Uchinoumi H, Tateishi H, Oda T, Okuda S, Doi M, Kobayashi S, Yamamoto T, Koseki N, Kyushiki H, Ikemoto N, Matsuzaki M.

Cardiovasc Res. 2010 Sep 1;87(4):609-17. doi: 10.1093/cvr/cvq108. Epub 2010 Apr 13.

20.

The H29D Mutation Does Not Enhance Cytosolic Ca2+ Activation of the Cardiac Ryanodine Receptor.

Xiao Z, Guo W, Yuen SM, Wang R, Zhang L, Van Petegem F, Chen SR.

PLoS One. 2015 Sep 25;10(9):e0139058. doi: 10.1371/journal.pone.0139058. eCollection 2015.

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