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Items: 1 to 20 of 94

1.

RasGRPs are targets of the anti-cancer agent ingenol-3-angelate.

Song X, Lopez-Campistrous A, Sun L, Dower NA, Kedei N, Yang J, Kelsey JS, Lewin NE, Esch TE, Blumberg PM, Stone JC.

PLoS One. 2013 Aug 21;8(8):e72331. doi: 10.1371/journal.pone.0072331. eCollection 2013.

2.

A proapoptotic signaling pathway involving RasGRP, Erk, and Bim in B cells.

Stang SL, Lopez-Campistrous A, Song X, Dower NA, Blumberg PM, Wender PA, Stone JC.

Exp Hematol. 2009 Jan;37(1):122-134. doi: 10.1016/j.exphem.2008.09.008.

3.

Integration of DAG signaling systems mediated by PKC-dependent phosphorylation of RasGRP3.

Teixeira C, Stang SL, Zheng Y, Beswick NS, Stone JC.

Blood. 2003 Aug 15;102(4):1414-20. Epub 2003 May 1.

4.

Characterization of the interaction of ingenol 3-angelate with protein kinase C.

Kedei N, Lundberg DJ, Toth A, Welburn P, Garfield SH, Blumberg PM.

Cancer Res. 2004 May 1;64(9):3243-55.

5.

Differential membrane binding and diacylglycerol recognition by C1 domains of RasGRPs.

Johnson JE, Goulding RE, Ding Z, Partovi A, Anthony KV, Beaulieu N, Tazmini G, Cornell RB, Kay RJ.

Biochem J. 2007 Sep 1;406(2):223-36.

6.

Phosphorylation of RasGRP3 on threonine 133 provides a mechanistic link between PKC and Ras signaling systems in B cells.

Zheng Y, Liu H, Coughlin J, Zheng J, Li L, Stone JC.

Blood. 2005 May 1;105(9):3648-54. Epub 2005 Jan 18.

7.

Regulation and Function of the RasGRP Family of Ras Activators in Blood Cells.

Stone JC.

Genes Cancer. 2011 Mar;2(3):320-34. doi: 10.1177/1947601911408082.

8.

RasGRP1 and RasGRP3 regulate B cell proliferation by facilitating B cell receptor-Ras signaling.

Coughlin JJ, Stang SL, Dower NA, Stone JC.

J Immunol. 2005 Dec 1;175(11):7179-84.

9.

Iridals are a novel class of ligands for phorbol ester receptors with modest selectivity for the RasGRP receptor subfamily.

Shao L, Lewin NE, Lorenzo PS, Hu Z, Enyedy IJ, Garfield SH, Stone JC, Marner FJ, Blumberg PM, Wang S.

J Med Chem. 2001 Nov 8;44(23):3872-80.

PMID:
11689073
10.

Bryostatin analogue-induced apoptosis in mantle cell lymphoma cell lines.

Lopez-Campistrous A, Song X, Schrier AJ, Wender PA, Dower NA, Stone JC.

Exp Hematol. 2012 Aug;40(8):646-56.e2. doi: 10.1016/j.exphem.2012.03.002. Epub 2012 Mar 28.

11.

Effects of protein kinase C modulation by PEP005, a novel ingenol angelate, on mitogen-activated protein kinase and phosphatidylinositol 3-kinase signaling in cancer cells.

Serova M, Ghoul A, Benhadji KA, Faivre S, Le Tourneau C, Cvitkovic E, Lokiec F, Lord J, Ogbourne SM, Calvo F, Raymond E.

Mol Cancer Ther. 2008 Apr;7(4):915-22. doi: 10.1158/1535-7163.MCT-07-2060.

12.

Phorbol esters modulate the Ras exchange factor RasGRP3.

Lorenzo PS, Kung JW, Bottorff DA, Garfield SH, Stone JC, Blumberg PM.

Cancer Res. 2001 Feb 1;61(3):943-9.

13.

HIV type 1 inhibition by protein kinase C modulatory compounds.

Warrilow D, Gardner J, Darnell GA, Suhrbier A, Harrich D.

AIDS Res Hum Retroviruses. 2006 Sep;22(9):854-64.

PMID:
16989610
15.

[RasGRP proteins--Ras-activating factors].

SzamaƂek M, Baer-Dubowska W.

Postepy Biochem. 2007;53(2):112-20. Review. Polish.

PMID:
17969871
16.

A diacylglycerol-protein kinase C-RasGRP1 pathway directs Ras activation upon antigen receptor stimulation of T cells.

Roose JP, Mollenauer M, Gupta VA, Stone J, Weiss A.

Mol Cell Biol. 2005 Jun;25(11):4426-41.

17.

Structural basis of RasGRP binding to high-affinity PKC ligands.

Rong SB, Enyedy IJ, Qiao L, Zhao L, Ma D, Pearce LL, Lorenzo PS, Stone JC, Blumberg PM, Wang S, Kozikowski AP.

J Med Chem. 2002 Feb 14;45(4):853-60.

PMID:
11831896
18.

Novel antileukemic compound ingenol 3-angelate inhibits T cell apoptosis by activating protein kinase Ctheta.

Lee WY, Hampson P, Coulthard L, Ali F, Salmon M, Lord JM, Scheel-Toellner D.

J Biol Chem. 2010 Jul 30;285(31):23889-98. doi: 10.1074/jbc.M109.041962. Epub 2010 May 14.

19.

N-benzyladriamycin-14-valerate (AD 198) exhibits potent anti-tumor activity on TRAF3-deficient mouse B lymphoma and human multiple myeloma.

Edwards SK, Moore CR, Liu Y, Grewal S, Covey LR, Xie P.

BMC Cancer. 2013 Oct 16;13:481. doi: 10.1186/1471-2407-13-481.

20.

A novel diacylglycerol-lactone shows marked selectivity in vitro among C1 domains of protein kinase C (PKC) isoforms alpha and delta as well as selectivity for RasGRP compared with PKCalpha.

Pu Y, Perry NA, Yang D, Lewin NE, Kedei N, Braun DC, Choi SH, Blumberg PM, Garfield SH, Stone JC, Duan D, Marquez VE.

J Biol Chem. 2005 Jul 22;280(29):27329-38. Epub 2005 May 27.

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