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Items: 1 to 20 of 118

1.

A new class of rhomboid protease inhibitors discovered by activity-based fluorescence polarization.

Wolf EV, Zeißler A, Vosyka O, Zeiler E, Sieber S, Verhelst SH.

PLoS One. 2013 Aug 22;8(8):e72307. doi: 10.1371/journal.pone.0072307. eCollection 2013.

2.

Activity-based probes for rhomboid proteases discovered in a mass spectrometry-based assay.

Vosyka O, Vinothkumar KR, Wolf EV, Brouwer AJ, Liskamp RM, Verhelst SH.

Proc Natl Acad Sci U S A. 2013 Feb 12;110(7):2472-7. doi: 10.1073/pnas.1215076110. Epub 2013 Jan 28.

3.

Inhibitor Fingerprinting of Rhomboid Proteases by Activity-Based Protein Profiling Reveals Inhibitor Selectivity and Rhomboid Autoprocessing.

Wolf EV, Zeissler A, Verhelst SH.

ACS Chem Biol. 2015 Oct 16;10(10):2325-33. doi: 10.1021/acschembio.5b00514. Epub 2015 Aug 7.

PMID:
26218717
4.

Substrate binding and specificity of rhomboid intramembrane protease revealed by substrate-peptide complex structures.

Zoll S, Stanchev S, Began J, Skerle J, Lepšík M, Peclinovská L, Majer P, Strisovsky K.

EMBO J. 2014 Oct 16;33(20):2408-21. doi: 10.15252/embj.201489367. Epub 2014 Sep 12.

5.

Untangling structure-function relationships in the rhomboid family of intramembrane proteases.

Brooks CL, Lemieux MJ.

Biochim Biophys Acta. 2013 Dec;1828(12):2862-72. doi: 10.1016/j.bbamem.2013.05.003. Review.

6.

The structural basis for catalysis and substrate specificity of a rhomboid protease.

Vinothkumar KR, Strisovsky K, Andreeva A, Christova Y, Verhelst S, Freeman M.

EMBO J. 2010 Nov 17;29(22):3797-809. doi: 10.1038/emboj.2010.243. Epub 2010 Oct 1.

7.

Activity Assays for Rhomboid Proteases.

Arutyunova E, Strisovsky K, Lemieux MJ.

Methods Enzymol. 2017;584:395-437. doi: 10.1016/bs.mie.2016.11.002. Epub 2016 Dec 8.

PMID:
28065272
8.

Crystal Structures and Inhibition Kinetics Reveal a Two-Stage Catalytic Mechanism with Drug Design Implications for Rhomboid Proteolysis.

Cho S, Dickey SW, Urban S.

Mol Cell. 2016 Feb 4;61(3):329-340. doi: 10.1016/j.molcel.2015.12.022. Epub 2016 Jan 21.

9.
10.

Inhibitors of rhomboid proteases.

Wolf EV, Verhelst SH.

Biochimie. 2016 Mar;122:38-47. doi: 10.1016/j.biochi.2015.07.007. Epub 2015 Jul 10. Review.

PMID:
26166068
11.

Influence of hydrophobic mismatch on the catalytic activity of Escherichia coli GlpG rhomboid protease.

Foo AC, Harvey BG, Metz JJ, Goto NK.

Protein Sci. 2015 Apr;24(4):464-73. doi: 10.1002/pro.2585. Epub 2014 Nov 4.

12.

Activity-based protein profiling of the Escherichia coli GlpG rhomboid protein delineates the catalytic core.

Sherratt AR, Blais DR, Ghasriani H, Pezacki JP, Goto NK.

Biochemistry. 2012 Oct 2;51(39):7794-803. doi: 10.1021/bi301087c. Epub 2012 Sep 21.

PMID:
22963263
13.

Mechanism and Inhibition of Rhomboid Proteases.

Strisovsky K.

Methods Enzymol. 2017;584:279-293. doi: 10.1016/bs.mie.2016.10.014. Epub 2016 Nov 22. Review.

PMID:
28065267
14.

Structure and mechanism of rhomboid protease.

Ha Y, Akiyama Y, Xue Y.

J Biol Chem. 2013 May 31;288(22):15430-6. doi: 10.1074/jbc.R112.422378. Epub 2013 Apr 12. Review.

15.

Large lateral movement of transmembrane helix S5 is not required for substrate access to the active site of rhomboid intramembrane protease.

Xue Y, Ha Y.

J Biol Chem. 2013 Jun 7;288(23):16645-54. doi: 10.1074/jbc.M112.438127. Epub 2013 Apr 22.

16.

Proteolytic action of GlpG, a rhomboid protease in the Escherichia coli cytoplasmic membrane.

Maegawa S, Ito K, Akiyama Y.

Biochemistry. 2005 Oct 18;44(41):13543-52.

PMID:
16216077
17.
18.

Cleavage of a multispanning membrane protein by an intramembrane serine protease.

Erez E, Bibi E.

Biochemistry. 2009 Dec 29;48(51):12314-22. doi: 10.1021/bi901648g.

PMID:
19919105
20.

Monocyclic β-lactams are selective, mechanism-based inhibitors of rhomboid intramembrane proteases.

Pierrat OA, Strisovsky K, Christova Y, Large J, Ansell K, Bouloc N, Smiljanic E, Freeman M.

ACS Chem Biol. 2011 Apr 15;6(4):325-35. doi: 10.1021/cb100314y. Epub 2011 Jan 12.

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