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Items: 1 to 20 of 81

1.

Arsenic trioxide inhibits viability of pancreatic cancer stem cells in culture and in a xenograft model via binding to SHH-Gli.

Han JB, Sang F, Chang JJ, Hua YQ, Shi WD, Tang LH, Liu LM.

Onco Targets Ther. 2013 Aug 19;6:1129-38. doi: 10.2147/OTT.S49148. eCollection 2013.

2.

Arsenic trioxide prevents osteosarcoma growth by inhibition of GLI transcription via DNA damage accumulation.

Nakamura S, Nagano S, Nagao H, Ishidou Y, Yokouchi M, Abematsu M, Yamamoto T, Komiya S, Setoguchi T.

PLoS One. 2013 Jul 8;8(7):e69466. doi: 10.1371/journal.pone.0069466. Print 2013.

3.

Arsenic trioxide inhibits human cancer cell growth and tumor development in mice by blocking Hedgehog/GLI pathway.

Beauchamp EM, Ringer L, Bulut G, Sajwan KP, Hall MD, Lee YC, Peaceman D, Ozdemirli M, Rodriguez O, Macdonald TJ, Albanese C, Toretsky JA, Uren A.

J Clin Invest. 2011 Jan;121(1):148-60. doi: 10.1172/JCI42874. Epub 2010 Dec 22.

4.

Targeting of the Hedgehog signal transduction pathway suppresses survival of malignant pleural mesothelioma cells in vitro.

You M, Varona-Santos J, Singh S, Robbins DJ, Savaraj N, Nguyen DM.

J Thorac Cardiovasc Surg. 2014 Jan;147(1):508-16. doi: 10.1016/j.jtcvs.2013.08.035. Epub 2013 Oct 4.

5.

Sonic hedgehog signaling inhibition provides opportunities for targeted therapy by sulforaphane in regulating pancreatic cancer stem cell self-renewal.

Rodova M, Fu J, Watkins DN, Srivastava RK, Shankar S.

PLoS One. 2012;7(9):e46083. doi: 10.1371/journal.pone.0046083. Epub 2012 Sep 28.

6.

A novel combination therapy with arsenic trioxide and parthenolide against pancreatic cancer cells.

Wang W, Adachi M, Zhang R, Zhou J, Zhu D.

Pancreas. 2009 May;38(4):e114-23. doi: 10.1097/MPA.0b013e3181a0b6f2.

PMID:
19342982
7.

Cyclopamine reverts acquired chemoresistance and down-regulates cancer stem cell markers in pancreatic cancer cell lines.

Yao J, An Y, Wie JS, Ji ZL, Lu ZP, Wu JL, Jiang KR, Chen P, Xu ZK, Miao Y.

Swiss Med Wkly. 2011 May 31;141:w13208. doi: 10.4414/smw.2011.13208.

8.

GANT-61 inhibits pancreatic cancer stem cell growth in vitro and in NOD/SCID/IL2R gamma null mice xenograft.

Fu J, Rodova M, Roy SK, Sharma J, Singh KP, Srivastava RK, Shankar S.

Cancer Lett. 2013 Mar 1;330(1):22-32. doi: 10.1016/j.canlet.2012.11.018. Epub 2012 Nov 28.

9.

Nicotine induces self-renewal of pancreatic cancer stem cells via neurotransmitter-driven activation of sonic hedgehog signalling.

Al-Wadei MH, Banerjee J, Al-Wadei HA, Schuller HM.

Eur J Cancer. 2016 Jan;52:188-96. doi: 10.1016/j.ejca.2015.10.003. Epub 2015 Dec 12.

10.

Sonic hedgehog-glioma associated oncogene homolog 1 signaling enhances drug resistance in CD44(+)/Musashi-1(+) gastric cancer stem cells.

Xu M, Gong A, Yang H, George SK, Jiao Z, Huang H, Jiang X, Zhang Y.

Cancer Lett. 2015 Dec 1;369(1):124-33. doi: 10.1016/j.canlet.2015.08.005. Epub 2015 Aug 11.

PMID:
26276718
11.

Sonic Hedgehog-GLI Family Zinc Finger 1 Signaling Pathway Promotes the Growth and Migration of Pancreatic Cancer Cells by Regulating the Transcription of Eukaryotic Translation Initiation Factor 5A2.

Xu X, Liu H, Zhang H, Dai W, Guo C, Xie C, Wei S, He S, Xu X.

Pancreas. 2015 Nov;44(8):1252-8. doi: 10.1097/MPA.0000000000000532.

PMID:
26465952
12.

A mouse model for embryonal tumors with multilayered rosettes uncovers the therapeutic potential of Sonic-hedgehog inhibitors.

Neumann JE, Wefers AK, Lambo S, Bianchi E, Bockstaller M, Dorostkar MM, Meister V, Schindler P, Korshunov A, von Hoff K, Nowak J, Warmuth-Metz M, Schneider MR, Renner-Müller I, Merk DJ, Shakarami M, Sharma T, Chavez L, Glass R, Chan JA, Taketo MM, Neumann P, Kool M, Schüller U.

Nat Med. 2017 Oct;23(10):1191-1202. doi: 10.1038/nm.4402. Epub 2017 Sep 11.

PMID:
28892064
13.

Arsenic trioxide inhibits tumor cell growth in malignant rhabdoid tumors in vitro and in vivo by targeting overexpressed Gli1.

Kerl K, Moreno N, Holsten T, Ahlfeld J, Mertins J, Hotfilder M, Kool M, Bartelheim K, Schleicher S, Handgretinger R, Schüller U, Meisterernst M, Frühwald MC.

Int J Cancer. 2014 Aug 15;135(4):989-95. doi: 10.1002/ijc.28719. Epub 2014 Jan 25.

14.

Ski modulate the characteristics of pancreatic cancer stem cells via regulating sonic hedgehog signaling pathway.

Song L, Chen X, Gao S, Zhang C, Qu C, Wang P, Liu L.

Tumour Biol. 2016 Oct 12. [Epub ahead of print]

PMID:
27734340
16.

Hedgehog signaling antagonist GDC-0449 (Vismodegib) inhibits pancreatic cancer stem cell characteristics: molecular mechanisms.

Singh BN, Fu J, Srivastava RK, Shankar S.

PLoS One. 2011;6(11):e27306. doi: 10.1371/journal.pone.0027306. Epub 2011 Nov 8.

17.

Synergistic inhibition of colon carcinoma cell growth by Hedgehog-Gli1 inhibitor arsenic trioxide and phosphoinositide 3-kinase inhibitor LY294002.

Cai X, Yu K, Zhang L, Li Y, Li Q, Yang Z, Shen T, Duan L, Xiong W, Wang W.

Onco Targets Ther. 2015 Apr 17;8:877-83. doi: 10.2147/OTT.S71034. eCollection 2015.

18.

Down-regulation of Sonic hedgehog signaling pathway activity is involved in 5-fluorouracil-induced apoptosis and motility inhibition in Hep3B cells.

Wang Q, Huang S, Yang L, Zhao L, Yin Y, Liu Z, Chen Z, Zhang H.

Acta Biochim Biophys Sin (Shanghai). 2008 Sep;40(9):819-29.

19.
20.

[Synergistic Inhibitory Effect of Arsenic Trioxide Combined with Itraconazole on Hedgehog Pathway of Multiple Myeloma NCI-H929 Cells].

Huang XB, Shi Y, Wang CS, Wang XD, Cheng J, Che FF.

Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2016 Oct;24(5):1459-1465. doi: 10.7534/j.issn.1009-2137.2016.05.032. Chinese.

PMID:
27784375

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