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Items: 1 to 20 of 114


Smac-mimetic-induced epithelial cell death reduces the growth of renal cysts.

Fan LX, Zhou X, Sweeney WE Jr, Wallace DP, Avner ED, Grantham JJ, Li X.

J Am Soc Nephrol. 2013 Dec;24(12):2010-22. doi: 10.1681/ASN.2013020176. Epub 2013 Aug 29.


Smac mimetic Birinapant induces apoptosis and enhances TRAIL potency in inflammatory breast cancer cells in an IAP-dependent and TNF-α-independent mechanism.

Allensworth JL, Sauer SJ, Lyerly HK, Morse MA, Devi GR.

Breast Cancer Res Treat. 2013 Jan;137(2):359-71. doi: 10.1007/s10549-012-2352-6. Epub 2012 Dec 7.


Sirtuin 1 inhibition delays cyst formation in autosomal-dominant polycystic kidney disease.

Zhou X, Fan LX, Sweeney WE Jr, Denu JM, Avner ED, Li X.

J Clin Invest. 2013 Jul;123(7):3084-98. doi: 10.1172/JCI64401. Epub 2013 Jun 17.


Apoptosis repressor with caspase recruitment domain modulates second mitochondrial-derived activator of caspases mimetic-induced cell death through BIRC2/MAP3K14 signalling in acute myeloid leukaemia.

Mak PY, Mak DH, Ruvolo V, Jacamo R, Kornblau SM, Kantarjian H, Andreeff M, Carter BZ.

Br J Haematol. 2014 Nov;167(3):376-84. doi: 10.1111/bjh.13054. Epub 2014 Jul 31. Erratum in: Br J Haematol. 2015 Nov;171(3):440.


c-Src inactivation reduces renal epithelial cell-matrix adhesion, proliferation, and cyst formation.

Elliott J, Zheleznova NN, Wilson PD.

Am J Physiol Cell Physiol. 2011 Aug;301(2):C522-9. doi: 10.1152/ajpcell.00163.2010. Epub 2011 Apr 20.


Macrophage migration inhibitory factor promotes cyst growth in polycystic kidney disease.

Chen L, Zhou X, Fan LX, Yao Y, Swenson-Fields KI, Gadjeva M, Wallace DP, Peters DJ, Yu A, Grantham JJ, Li X.

J Clin Invest. 2015 Jun;125(6):2399-412. doi: 10.1172/JCI80467. Epub 2015 May 11.


VEGF receptor inhibition blocks liver cyst growth in pkd2(WS25/-) mice.

Amura CR, Brodsky KS, Groff R, Gattone VH, Voelkel NF, Doctor RB.

Am J Physiol Cell Physiol. 2007 Jul;293(1):C419-28. Epub 2007 May 2.


Birinapant (TL32711), a bivalent SMAC mimetic, targets TRAF2-associated cIAPs, abrogates TNF-induced NF-κB activation, and is active in patient-derived xenograft models.

Benetatos CA, Mitsuuchi Y, Burns JM, Neiman EM, Condon SM, Yu G, Seipel ME, Kapoor GS, Laporte MG, Rippin SR, Deng Y, Hendi MS, Tirunahari PK, Lee YH, Haimowitz T, Alexander MD, Graham MA, Weng D, Shi Y, McKinlay MA, Chunduru SK.

Mol Cancer Ther. 2014 Apr;13(4):867-79. doi: 10.1158/1535-7163.MCT-13-0798. Epub 2014 Feb 21. Erratum in: Mol Cancer Ther. 2014 Sep;13(9):2246-7. Dosage error in article text.


Berberine slows cell growth in autosomal dominant polycystic kidney disease cells.

Bonon A, Mangolini A, Pinton P, Del Senno L, Aguiari G.

Biochem Biophys Res Commun. 2013 Nov 22;441(3):668-74. doi: 10.1016/j.bbrc.2013.10.076. Epub 2013 Oct 31.


Pkd1 regulates immortalized proliferation of renal tubular epithelial cells through p53 induction and JNK activation.

Nishio S, Hatano M, Nagata M, Horie S, Koike T, Tokuhisa T, Mochizuki T.

J Clin Invest. 2005 Apr;115(4):910-8. Epub 2005 Mar 3.


Overcoming cancer cell resistance to Smac mimetic induced apoptosis by modulating cIAP-2 expression.

Petersen SL, Peyton M, Minna JD, Wang X.

Proc Natl Acad Sci U S A. 2010 Jun 29;107(26):11936-41. doi: 10.1073/pnas.1005667107. Epub 2010 Jun 14.


Cell Proliferation and Apoptosis in ADPKD.

Lee EJ.

Adv Exp Med Biol. 2016;933:25-34. Review.


TNF-alpha induces two distinct caspase-8 activation pathways.

Wang L, Du F, Wang X.

Cell. 2008 May 16;133(4):693-703. doi: 10.1016/j.cell.2008.03.036.


Inhibiting the HSP90 chaperone slows cyst growth in a mouse model of autosomal dominant polycystic kidney disease.

Seeger-Nukpezah T, Proia DA, Egleston BL, Nikonova AS, Kent T, Cai KQ, Hensley HH, Ying W, Chimmanamada D, Serebriiskii IG, Golemis EA.

Proc Natl Acad Sci U S A. 2013 Jul 30;110(31):12786-91. doi: 10.1073/pnas.1301904110. Epub 2013 Jul 15.


Novel inhibitors of nuclear transport cause cell cycle arrest and decrease cyst growth in ADPKD associated with decreased CDK4 levels.

Tan M, Wettersten HI, Chu K, Huso DL, Watnick T, Friedlander S, Landesman Y, Weiss RH.

Am J Physiol Renal Physiol. 2014 Dec 1;307(11):F1179-86. doi: 10.1152/ajprenal.00406.2014. Epub 2014 Sep 18.


Smac mimetic bypasses apoptosis resistance in FADD- or caspase-8-deficient cells by priming for tumor necrosis factor α-induced necroptosis.

Laukens B, Jennewein C, Schenk B, Vanlangenakker N, Schier A, Cristofanon S, Zobel K, Deshayes K, Vucic D, Jeremias I, Bertrand MJ, Vandenabeele P, Fulda S.

Neoplasia. 2011 Oct;13(10):971-9.


Cyst formation and activation of the extracellular regulated kinase pathway after kidney specific inactivation of Pkd1.

Shibazaki S, Yu Z, Nishio S, Tian X, Thomson RB, Mitobe M, Louvi A, Velazquez H, Ishibe S, Cantley LG, Igarashi P, Somlo S.

Hum Mol Genet. 2008 Jun 1;17(11):1505-16. doi: 10.1093/hmg/ddn039. Epub 2008 Feb 7.


Scattered Deletion of PKD1 in Kidneys Causes a Cystic Snowball Effect and Recapitulates Polycystic Kidney Disease.

Leonhard WN, Zandbergen M, Veraar K, van den Berg S, van der Weerd L, Breuning M, de Heer E, Peters DJ.

J Am Soc Nephrol. 2015 Jun;26(6):1322-33. doi: 10.1681/ASN.2013080864. Epub 2014 Oct 31.


Combination effects of SMAC mimetic birinapant with TNFα, TRAIL, and docetaxel in preclinical models of HNSCC.

Eytan DF, Snow GE, Carlson SG, Schiltz S, Chen Z, Van Waes C.

Laryngoscope. 2015 Mar;125(3):E118-24. doi: 10.1002/lary.25056. Epub 2014 Nov 28.

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