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Items: 1 to 20 of 104

1.

Alpha 7 integrin preserves the function of the extensor digitorum longus muscle in dystrophin-null mice.

Hakim CH, Burkin DJ, Duan D.

J Appl Physiol (1985). 2013 Nov 1;115(9):1388-92. doi: 10.1152/japplphysiol.00602.2013. Epub 2013 Aug 29.

2.

Severe muscular dystrophy in mice that lack dystrophin and alpha7 integrin.

Rooney JE, Welser JV, Dechert MA, Flintoff-Dye NL, Kaufman SJ, Burkin DJ.

J Cell Sci. 2006 Jun 1;119(Pt 11):2185-95. Epub 2006 May 9.

3.

Sarcospan integration into laminin-binding adhesion complexes that ameliorate muscular dystrophy requires utrophin and α7 integrin.

Marshall JL, Oh J, Chou E, Lee JA, Holmberg J, Burkin DJ, Crosbie-Watson RH.

Hum Mol Genet. 2015 Apr 1;24(7):2011-22. doi: 10.1093/hmg/ddu615. Epub 2014 Dec 11.

4.

Dystrophin and utrophin expression require sarcospan: loss of α7 integrin exacerbates a newly discovered muscle phenotype in sarcospan-null mice.

Marshall JL, Chou E, Oh J, Kwok A, Burkin DJ, Crosbie-Watson RH.

Hum Mol Genet. 2012 Oct 15;21(20):4378-93. Epub 2012 Jul 13.

5.

AAV-mediated overexpression of human α7 integrin leads to histological and functional improvement in dystrophic mice.

Heller KN, Montgomery CL, Janssen PM, Clark KR, Mendell JR, Rodino-Klapac LR.

Mol Ther. 2013 Mar;21(3):520-5. doi: 10.1038/mt.2012.281. Epub 2013 Jan 15.

6.

Myotendinous junction defects and reduced force transmission in mice that lack alpha7 integrin and utrophin.

Welser JV, Rooney JE, Cohen NC, Gurpur PB, Singer CA, Evans RA, Haines BA, Burkin DJ.

Am J Pathol. 2009 Oct;175(4):1545-54. doi: 10.2353/ajpath.2009.090052. Epub 2009 Sep 3.

7.

Absence of alpha 7 integrin in dystrophin-deficient mice causes a myopathy similar to Duchenne muscular dystrophy.

Guo C, Willem M, Werner A, Raivich G, Emerson M, Neyses L, Mayer U.

Hum Mol Genet. 2006 Mar 15;15(6):989-98. Epub 2006 Feb 13.

PMID:
16476707
8.

Levels of α7 integrin and laminin-α2 are increased following prednisone treatment in the mdx mouse and GRMD dog models of Duchenne muscular dystrophy.

Wuebbles RD, Sarathy A, Kornegay JN, Burkin DJ.

Dis Model Mech. 2013 Sep;6(5):1175-84. doi: 10.1242/dmm.012211. Epub 2013 Jul 11.

9.

SU9516 Increases α7β1 Integrin and Ameliorates Disease Progression in the mdx Mouse Model of Duchenne Muscular Dystrophy.

Sarathy A, Wuebbles RD, Fontelonga TM, Tarchione AR, Mathews Griner LA, Heredia DJ, Nunes AM, Duan S, Brewer PD, Van Ry T, Hennig GW, Gould TW, Dulcey AE, Wang A, Xu X, Chen CZ, Hu X, Zheng W, Southall N, Ferrer M, Marugan J, Burkin DJ.

Mol Ther. 2017 Jun 7;25(6):1395-1407. doi: 10.1016/j.ymthe.2017.03.022. Epub 2017 Apr 5.

10.

Secondary reduction of alpha7B integrin in laminin alpha2 deficient congenital muscular dystrophy supports an additional transmembrane link in skeletal muscle.

Cohn RD, Mayer U, Saher G, Herrmann R, van der Flier A, Sonnenberg A, Sorokin L, Voit T.

J Neurol Sci. 1999 Mar 1;163(2):140-52.

PMID:
10371075
11.

Enhanced expression of the alpha 7 beta 1 integrin reduces muscular dystrophy and restores viability in dystrophic mice.

Burkin DJ, Wallace GQ, Nicol KJ, Kaufman DJ, Kaufman SJ.

J Cell Biol. 2001 Mar 19;152(6):1207-18.

12.

iNOS ablation does not improve specific force of the extensor digitorum longus muscle in dystrophin-deficient mdx4cv mice.

Li D, Shin JH, Duan D.

PLoS One. 2011;6(6):e21618. doi: 10.1371/journal.pone.0021618. Epub 2011 Jun 30.

13.

Constitutive properties, not molecular adaptations, mediate extraocular muscle sparing in dystrophic mdx mice.

Porter JD, Merriam AP, Khanna S, Andrade FH, Richmonds CR, Leahy P, Cheng G, Karathanasis P, Zhou X, Kusner LL, Adams ME, Willem M, Mayer U, Kaminski HJ.

FASEB J. 2003 May;17(8):893-5. Epub 2003 Mar 28.

PMID:
12670877
14.

Truncated dystrophins reduce muscle stiffness in the extensor digitorum longus muscle of mdx mice.

Hakim CH, Duan D.

J Appl Physiol (1985). 2013 Feb 15;114(4):482-9. doi: 10.1152/japplphysiol.00866.2012. Epub 2012 Dec 6.

15.

Laminin-111 protein therapy prevents muscle disease in the mdx mouse model for Duchenne muscular dystrophy.

Rooney JE, Gurpur PB, Burkin DJ.

Proc Natl Acad Sci U S A. 2009 May 12;106(19):7991-6. doi: 10.1073/pnas.0811599106. Epub 2009 Apr 28. Erratum in: Proc Natl Acad Sci U S A. 2009 Sep 8;106(36):15514.

16.

Nitrosative stress elicited by nNOSµ delocalization inhibits muscle force in dystrophin-null mice.

Li D, Yue Y, Lai Y, Hakim CH, Duan D.

J Pathol. 2011 Jan;223(1):88-98. doi: 10.1002/path.2799. Epub 2010 Oct 28.

17.

The passive mechanical properties of the extensor digitorum longus muscle are compromised in 2- to 20-mo-old mdx mice.

Hakim CH, Grange RW, Duan D.

J Appl Physiol (1985). 2011 Jun;110(6):1656-63. doi: 10.1152/japplphysiol.01425.2010. Epub 2011 Mar 17.

18.

Human α7 Integrin Gene (ITGA7) Delivered by Adeno-Associated Virus Extends Survival of Severely Affected Dystrophin/Utrophin-Deficient Mice.

Heller KN, Montgomery CL, Shontz KM, Clark KR, Mendell JR, Rodino-Klapac LR.

Hum Gene Ther. 2015 Oct;26(10):647-56. doi: 10.1089/hum.2015.062. Epub 2015 Aug 11.

19.

Dystrophin expression following the transplantation of normal muscle precursor cells protects mdx muscle from contraction-induced damage.

Rousseau J, Dumont N, Lebel C, Quenneville SP, Côté CH, Frenette J, Tremblay JP.

Cell Transplant. 2010;19(5):589-96. doi: 10.3727/096368910X4863235.

PMID:
20650035
20.

β1D chain increases α7β1 integrin and laminin and protects against sarcolemmal damage in mdx mice.

Liu J, Milner DJ, Boppart MD, Ross RS, Kaufman SJ.

Hum Mol Genet. 2012 Apr 1;21(7):1592-603. doi: 10.1093/hmg/ddr596. Epub 2011 Dec 16.

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