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Items: 1 to 20 of 94

1.

Synthesis of saxitoxin derivatives bearing guanidine and urea groups at C13 and evaluation of their inhibitory activity on voltage-gated sodium channels.

Akimoto T, Masuda A, Yotsu-Yamashita M, Hirokawa T, Nagasawa K.

Org Biomol Chem. 2013 Oct 14;11(38):6642-9. doi: 10.1039/c3ob41398e. Epub 2013 Aug 30.

PMID:
23989458
2.

Synthesis of skeletal analogues of saxitoxin derivatives and evaluation of their inhibitory activity on sodium ion channels Na(V)1.4 and Na(V)1.5.

Shinohara R, Akimoto T, Iwamoto O, Hirokawa T, Yotsu-Yamashita M, Yamaoka K, Nagasawa K.

Chemistry. 2011 Oct 17;17(43):12144-52. doi: 10.1002/chem.201101058. Epub 2011 Sep 16.

PMID:
21922571
3.

De novo synthesis of modified saxitoxins for sodium ion channel study.

Andresen BM, Du Bois J.

J Am Chem Soc. 2009 Sep 9;131(35):12524-5. doi: 10.1021/ja904179f.

4.

The potencies of synthetic analogues of saxitoxin and the absolute stereoselectivity of decarbamoyl saxitoxin.

Strichartz GR, Hall S, Magnani B, Hong CY, Kishi Y, Debin JA.

Toxicon. 1995 Jun;33(6):723-37.

PMID:
7676464
5.

Fluorescent saxitoxins for live cell imaging of single voltage-gated sodium ion channels beyond the optical diffraction limit.

Ondrus AE, Lee HL, Iwanaga S, Parsons WH, Andresen BM, Moerner WE, Du Bois J.

Chem Biol. 2012 Jul 27;19(7):902-12. doi: 10.1016/j.chembiol.2012.05.021.

6.

Saxitoxin.

Thottumkara AP, Parsons WH, Du Bois J.

Angew Chem Int Ed Engl. 2014 Jun 2;53(23):5760-84. doi: 10.1002/anie.201308235. Epub 2014 Apr 25. Review.

PMID:
24771635
7.

Role of Na(v)1.9 in activity-dependent axon growth in motoneurons.

Subramanian N, Wetzel A, Dombert B, Yadav P, Havlicek S, Jablonka S, Nassar MA, Blum R, Sendtner M.

Hum Mol Genet. 2012 Aug 15;21(16):3655-67. doi: 10.1093/hmg/dds195. Epub 2012 May 28.

PMID:
22641814
8.

Actions of epimers of 12-(OH)-reduced saxitoxin and of 11-(OSO3)-saxitoxin on squid axon.

Kao CY, Kao PN, James-Kracke MR, Koehn FE, Wichmann CF, Schnoes HK.

Toxicon. 1985;23(4):647-55.

PMID:
2414863
9.

Effects of saxitoxin analogues and ligand competition on sodium currents of squid axons.

Frace AM, Hall S, Brodwick MS, Eaton DC.

Am J Physiol. 1986 Aug;251(2 Pt 1):C159-66.

PMID:
2426954
10.

Site-directed mutagenesis of the putative pore region of the rat IIA sodium channel.

Kontis KJ, Goldin AL.

Mol Pharmacol. 1993 Apr;43(4):635-44.

PMID:
8386312
11.

Total synthesis of (-)- and (+)-decarbamoyloxysaxitoxin and (+)-saxitoxin.

Iwamoto O, Shinohara R, Nagasawa K.

Chem Asian J. 2009 Feb 2;4(2):277-85. doi: 10.1002/asia.200800382.

PMID:
19040253
12.

Synthesis of a tricyclic bisguanidine compound structurally related to saxitoxin and its identification in paralytic shellfish toxin-producing microorganisms.

Tsuchiya S, Cho Y, Konoki K, Nagasawa K, Oshima Y, Yotsu-Yamashita M.

Chemistry. 2015 May 18;21(21):7835-40. doi: 10.1002/chem.201500064. Epub 2015 Apr 14.

PMID:
25873235
13.

Cooccupancy of the outer vestibule of voltage-gated sodium channels by micro-conotoxin KIIIA and saxitoxin or tetrodotoxin.

Zhang MM, Gruszczynski P, Walewska A, Bulaj G, Olivera BM, Yoshikami D.

J Neurophysiol. 2010 Jul;104(1):88-97. doi: 10.1152/jn.00145.2010. Epub 2010 Apr 21.

15.

An ab initio study of the guanidinium groups in saxitoxin.

Sapse AM, Rothchild R, Rhee K.

J Mol Model. 2006 Jan;12(2):140-5. Epub 2005 Nov 8.

PMID:
16283117
16.
17.

Development of saxitoxin-conjugated affinity gels.

Watanabe R, Samusawa-Saito R, Oshima Y.

Bioconjug Chem. 2006 Mar-Apr;17(2):459-65.

PMID:
16536478
18.

Saxitoxin blocks L-type ICa.

Su Z, Sheets M, Ishida H, Li F, Barry WH.

J Pharmacol Exp Ther. 2004 Jan;308(1):324-9. Epub 2003 Oct 17.

19.

A 18F-labeled saxitoxin derivative for in vivo PET-MR imaging of voltage-gated sodium channel expression following nerve injury.

Hoehne A, Behera D, Parsons WH, James ML, Shen B, Borgohain P, Bodapati D, Prabhakar A, Gambhir SS, Yeomans DC, Biswal S, Chin FT, Du Bois J.

J Am Chem Soc. 2013 Dec 4;135(48):18012-5. doi: 10.1021/ja408300e. Epub 2013 Nov 21.

PMID:
24261833
20.

A synthesis of (+)-saxitoxin.

Fleming JJ, Du Bois J.

J Am Chem Soc. 2006 Mar 29;128(12):3926-7.

PMID:
16551097

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