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Items: 1 to 20 of 121

1.

Common CYP2D6 polymorphisms affecting alternative splicing and transcription: long-range haplotypes with two regulatory variants modulate CYP2D6 activity.

Wang D, Poi MJ, Sun X, Gaedigk A, Leeder JS, Sadee W.

Hum Mol Genet. 2014 Jan 1;23(1):268-78. doi: 10.1093/hmg/ddt417. Epub 2013 Aug 28.

2.

Functional characterization of CYP2D6 enhancer polymorphisms.

Wang D, Papp AC, Sun X.

Hum Mol Genet. 2015 Mar 15;24(6):1556-62. doi: 10.1093/hmg/ddu566. Epub 2014 Nov 7.

3.

Polymorphisms and phenotypic analysis of cytochrome P450 2D6 in the Tibetan population.

Jin TB, Ma LF, Zhang JY, Yuan DY, Sun Q, Zong TY, Geng TT, Cui YL, Kang LL, Chen C.

Gene. 2013 Sep 15;527(1):360-5. doi: 10.1016/j.gene.2013.03.110. Epub 2013 May 3.

PMID:
23644254
4.

Polymorphism of human cytochrome P450 2D6 and its clinical significance: Part I.

Zhou SF.

Clin Pharmacokinet. 2009;48(11):689-723. doi: 10.2165/11318030-000000000-00000. Review.

PMID:
19817501
5.

Genetic polymorphism, linkage disequilibrium, haplotype structure and novel allele analysis of CYP2C19 and CYP2D6 in Han Chinese.

Zhou Q, Yu XM, Lin HB, Wang L, Yun QZ, Hu SN, Wang DM.

Pharmacogenomics J. 2009 Dec;9(6):380-94. doi: 10.1038/tpj.2009.31. Epub 2009 Jul 28.

PMID:
19636337
6.

Impaired expression of CYP2D6 in intermediate metabolizers carrying the *41 allele caused by the intronic SNP 2988G>A: evidence for modulation of splicing events.

Toscano C, Klein K, Blievernicht J, Schaeffeler E, Saussele T, Raimundo S, Eichelbaum M, Schwab M, Zanger UM.

Pharmacogenet Genomics. 2006 Oct;16(10):755-66.

PMID:
17001295
7.
8.

Linkage disequilibrium mapping identifies a 390 kb region associated with CYP2D6 poor drug metabolising activity.

Hosking LK, Boyd PR, Xu CF, Nissum M, Cantone K, Purvis IJ, Khakhar R, Barnes MR, Liberwirth U, Hagen-Mann K, Ehm MG, Riley JH.

Pharmacogenomics J. 2002;2(3):165-75.

9.

Identification and characterization of novel sequence variations in the cytochrome P4502D6 (CYP2D6) gene in African Americans.

Gaedigk A, Bhathena A, Ndjountché L, Pearce RE, Abdel-Rahman SM, Alander SW, Bradford LD, Rogan PK, Leeder JS.

Pharmacogenomics J. 2005;5(3):173-82. Erratum in: Pharmacogenomics J. 2005;5(4):276. Rogan, PK [added].

10.

Polymorphism of human cytochrome P450 2D6 and its clinical significance: part II.

Zhou SF.

Clin Pharmacokinet. 2009;48(12):761-804. doi: 10.2165/11318070-000000000-00000.

PMID:
19902987
11.

Cytochrome P450 2D6 variants in a Caucasian population: allele frequencies and phenotypic consequences.

Sachse C, Brockmöller J, Bauer S, Roots I.

Am J Hum Genet. 1997 Feb;60(2):284-95.

12.

Discovery of novel functional variants and extensive evaluation of CYP2D6 genetic polymorphisms in Koreans.

Lee SJ, Lee SS, Jung HJ, Kim HS, Park SJ, Yeo CW, Shin JG.

Drug Metab Dispos. 2009 Jul;37(7):1464-70. doi: 10.1124/dmd.108.022368. Epub 2009 Apr 13.

13.

Molecular diversity at the CYP2D6 locus in the Mediterranean region.

Fuselli S, Dupanloup I, Frigato E, Cruciani F, Scozzari R, Moral P, Sistonen J, Sajantila A, Barbujani G.

Eur J Hum Genet. 2004 Nov;12(11):916-24.

14.

Genetic polymorphism in cytochrome P450 2D6 (CYP2D6): Population distribution of CYP2D6 activity.

Neafsey P, Ginsberg G, Hattis D, Sonawane B.

J Toxicol Environ Health B Crit Rev. 2009;12(5-6):334-61. doi: 10.1080/10937400903158342. Review.

PMID:
20183526
15.

Novel cytochrome P450-2D6 promoter sequence variations in hepatitis C positive and negative subjects.

Ho MT, Kelly EJ, Bodor M, Bui T, Kowdley KV, Ho RJ.

Ann Hepatol. 2011 Jul-Sep;10(3):327-32.

16.

A silent mutation (2939G>A, exon 6; CYP2D6*59) leading to impaired expression and function of CYP2D6.

Toscano C, Raimundo S, Klein K, Eichelbaum M, Schwab M, Zanger UM.

Pharmacogenet Genomics. 2006 Oct;16(10):767-70.

PMID:
17001296
17.

Functional analysis of CYP2D6.31 variant: homology modeling suggests possible disruption of redox partner interaction by Arg440His substitution.

Allorge D, Bréant D, Harlow J, Chowdry J, Lo-Guidice JM, Chevalier D, Cauffiez C, Lhermitte M, Blaney FE, Tucker GT, Broly F, Ellis SW.

Proteins. 2005 May 1;59(2):339-46.

PMID:
15726636
18.

Genetic polymorphism of hepatocyte nuclear factor-4alpha influences human cytochrome P450 2D6 activity.

Lee SS, Cha EY, Jung HJ, Shon JH, Kim EY, Yeo CW, Shin JG.

Hepatology. 2008 Aug;48(2):635-45. doi: 10.1002/hep.22396.

PMID:
18666237
20.

Effects of single SNPs, haplotypes, and whole-genome LD maps on accuracy of association mapping.

Maniatis N, Collins A, Morton NE.

Genet Epidemiol. 2007 Apr;31(3):179-88.

PMID:
17285621

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