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Anti-tumour activity of longikaurin A (LK-A), a novel natural diterpenoid, in nasopharyngeal carcinoma.

Zou QF, Du JK, Zhang H, Wang HB, Hu ZD, Chen SP, Du Y, Li MZ, Xie D, Zou J, Sun HD, Pu JX, Zeng MS.

J Transl Med. 2013 Aug 28;11:200. doi: 10.1186/1479-5876-11-200.


Longikaurin A, a natural ent-kaurane, induces G2/M phase arrest via downregulation of Skp2 and apoptosis induction through ROS/JNK/c-Jun pathway in hepatocellular carcinoma cells.

Liao YJ, Bai HY, Li ZH, Zou J, Chen JW, Zheng F, Zhang JX, Mai SJ, Zeng MS, Sun HD, Pu JX, Xie D.

Cell Death Dis. 2014 Mar 20;5:e1137. doi: 10.1038/cddis.2014.66.


Effusanin E suppresses nasopharyngeal carcinoma cell growth by inhibiting NF-κB and COX-2 signaling.

Zhuang M, Zhao M, Qiu H, Shi D, Wang J, Tian Y, Lin L, Deng W.

PLoS One. 2014 Oct 21;9(10):e109951. doi: 10.1371/journal.pone.0109951. eCollection 2014.


Oridonin triggers apoptosis in colorectal carcinoma cells and suppression of microRNA-32 expression augments oridonin-mediated apoptotic effects.

Yang J, Jiang H, Wang C, Yang B, Zhao L, Hu D, Qiu G, Dong X, Xiao B.

Biomed Pharmacother. 2015 May;72:125-34. doi: 10.1016/j.biopha.2015.04.016. Epub 2015 Apr 27.


[Longikaurin A induces apoptosis of multiple myeloma H929 cells].

Zhao S, Pu JX, Sun HD, Wu YL.

Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2012 Jun;20(3):611-5. Chinese.


Xerophilusin B induces cell cycle arrest and apoptosis in esophageal squamous cell carcinoma cells and does not cause toxicity in nude mice.

Yao R, Chen Z, Zhou C, Luo M, Shi X, Li J, Gao Y, Zhou F, Pu J, Sun H, He J.

J Nat Prod. 2015 Jan 23;78(1):10-6. doi: 10.1021/np500429w. Epub 2015 Jan 2.


Oridonin inhibits BxPC-3 cell growth through cell apoptosis.

Xu B, Shen W, Liu X, Zhang T, Ren J, Fan Y, Xu J.

Acta Biochim Biophys Sin (Shanghai). 2015 Mar;47(3):164-73. doi: 10.1093/abbs/gmu134. Epub 2015 Feb 3.


A Novel Potent Anticancer Compound Optimized from a Natural Oridonin Scaffold Induces Apoptosis and Cell Cycle Arrest through the Mitochondrial Pathway.

Xu S, Yao H, Luo S, Zhang YK, Yang DH, Li D, Wang G, Hu M, Qiu Y, Wu X, Yao H, Xie W, Chen ZS, Xu J.

J Med Chem. 2017 Feb 23;60(4):1449-1468. doi: 10.1021/acs.jmedchem.6b01652. Epub 2017 Feb 13.


Therapeutic effect of TMZ-POH on human nasopharyngeal carcinoma depends on reactive oxygen species accumulation.

Xie L, Song X, Guo W, Wang X, Wei L, Li Y, Lv L, Wang W, Chen TC, Song X.

Oncotarget. 2016 Jan 12;7(2):1651-62. doi: 10.18632/oncotarget.6410.


The therapeutic effects of Longikaurin A, a natural ent-kauranoid, in esophageal squamous cell carcinoma depend on ROS accumulation and JNK/p38 MAPK activation.

Che Y, Wang J, Yuan Z, Li Y, Lu Z, Zhang Z, Zhang J, Wan J, Sun H, Chen Z, Pu J, He J.

Toxicol Lett. 2017 Aug 8. pii: S0378-4274(17)31165-7. doi: 10.1016/j.toxlet.2017.08.005. [Epub ahead of print]


Oridonin Inhibits Cell Proliferation and Induces Apoptosis in Rheumatoid Arthritis Fibroblast-Like Synoviocytes.

Shang CH, Zhang QQ, Zhou JH.

Inflammation. 2016 Apr;39(2):873-80. doi: 10.1007/s10753-016-0318-2.


Apoptosis induced by low-dose paclitaxel is associated with p53 upregulation in nasopharyngeal carcinoma cells.

Tan G, Heqing L, Jiangbo C, Ming J, Yanhong M, Xianghe L, Hong S, Li G.

Int J Cancer. 2002 Jan 10;97(2):168-72.


Longikaurin A, a natural ent-kaurane, suppresses stemness in nasopharyngeal carcinoma cells.

Yuan Y, Du Y, Hu XY, Liu MY, Du JK, Liu XM, Yu HE, Wang TZ, Pu JX, Zhong Q, Zou QF.

Oncol Lett. 2017 Mar;13(3):1672-1680. doi: 10.3892/ol.2017.5625. Epub 2017 Jan 19.


A new curcumin analogue exhibits enhanced antitumor activity in nasopharyngeal carcinoma.

Pan Y, Xiao J, Liang G, Wang M, Wang D, Wang S, Yang H.

Oncol Rep. 2013 Jul;30(1):239-45. doi: 10.3892/or.2013.2457. Epub 2013 May 14.


Therapeutic efficacy of seliciclib in combination with ionizing radiation for human nasopharyngeal carcinoma.

Hui AB, Yue S, Shi W, Alajez NM, Ito E, Green SR, Frame S, O'Sullivan B, Liu FF.

Clin Cancer Res. 2009 Jun 1;15(11):3716-24. doi: 10.1158/1078-0432.CCR-08-2790. Epub 2009 May 26.


JD enhances the anti-tumour effects of low-dose paclitaxel on gastric cancer MKN45 cells both in vitro and in vivo.

Wang C, Wang R, Zhou K, Wang S, Wang J, Shi H, Dou Y, Yang D, Chang L, Shi X, Liu Y, Xu X, Zhang X, Ke Y, Liu H.

Cancer Chemother Pharmacol. 2016 Nov;78(5):971-982. Epub 2016 Sep 12.


Physcion, a naturally occurring anthraquinone derivative, induces apoptosis and autophagy in human nasopharyngeal carcinoma.

Pang MJ, Yang Z, Zhang XL, Liu ZF, Fan J, Zhang HY.

Acta Pharmacol Sin. 2016 Dec;37(12):1623-1640. doi: 10.1038/aps.2016.98. Epub 2016 Oct 3.


Activation of lytic cycle of Epstein-Barr virus by suberoylanilide hydroxamic acid leads to apoptosis and tumor growth suppression of nasopharyngeal carcinoma.

Hui KF, Ho DN, Tsang CM, Middeldorp JM, Tsao GS, Chiang AK.

Int J Cancer. 2012 Oct 15;131(8):1930-40. doi: 10.1002/ijc.27439. Epub 2012 Mar 8.

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