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Items: 1 to 20 of 109

1.

Fibrosis caused by loss of PTEN expression in mouse fibroblasts is crucially dependent on CCN2.

Liu S, Parapuram SK, Leask A.

Arthritis Rheum. 2013 Nov;65(11):2940-4. doi: 10.1002/art.38121.

2.

Loss of PTEN expression by dermal fibroblasts causes skin fibrosis.

Parapuram SK, Shi-wen X, Elliott C, Welch ID, Jones H, Baron M, Denton CP, Abraham DJ, Leask A.

J Invest Dermatol. 2011 Oct;131(10):1996-2003. doi: 10.1038/jid.2011.156. Epub 2011 Jun 9.

3.

Loss of PTEN expression by mouse fibroblasts results in lung fibrosis through a CCN2-dependent mechanism.

Parapuram SK, Thompson K, Tsang M, Hutchenreuther J, Bekking C, Liu S, Leask A.

Matrix Biol. 2015 Apr;43:35-41. doi: 10.1016/j.matbio.2015.01.017. Epub 2015 Jan 30.

PMID:
25644104
4.

CCN2 is required for bleomycin-induced skin fibrosis in mice.

Liu S, Shi-wen X, Abraham DJ, Leask A.

Arthritis Rheum. 2011 Jan;63(1):239-46. doi: 10.1002/art.30074.

5.

CCN2 expression by fibroblasts is not required for cutaneous tissue repair.

Liu S, Thompson K, Leask A.

Wound Repair Regen. 2014 Jan-Feb;22(1):119-24. doi: 10.1111/wrr.12131.

PMID:
24393160
6.

Pivotal role of connective tissue growth factor in lung fibrosis: MAPK-dependent transcriptional activation of type I collagen.

Ponticos M, Holmes AM, Shi-wen X, Leoni P, Khan K, Rajkumar VS, Hoyles RK, Bou-Gharios G, Black CM, Denton CP, Abraham DJ, Leask A, Lindahl GE.

Arthritis Rheum. 2009 Jul;60(7):2142-55. doi: 10.1002/art.24620.

7.

Adenosine A2A receptors in diffuse dermal fibrosis: pathogenic role in human dermal fibroblasts and in a murine model of scleroderma.

Chan ES, Fernandez P, Merchant AA, Montesinos MC, Trzaska S, Desai A, Tung CF, Khoa DN, Pillinger MH, Reiss AB, Tomic-Canic M, Chen JF, Schwarzschild MA, Cronstein BN.

Arthritis Rheum. 2006 Aug;54(8):2632-42.

8.

Selective expression of connective tissue growth factor in fibroblasts in vivo promotes systemic tissue fibrosis.

Sonnylal S, Shi-Wen X, Leoni P, Naff K, Van Pelt CS, Nakamura H, Leask A, Abraham D, Bou-Gharios G, de Crombrugghe B.

Arthritis Rheum. 2010 May;62(5):1523-32. doi: 10.1002/art.27382.

9.

Endoglin promotes TGF-β/Smad1 signaling in scleroderma fibroblasts.

Morris E, Chrobak I, Bujor A, Hant F, Mummery C, Ten Dijke P, Trojanowska M.

J Cell Physiol. 2011 Dec;226(12):3340-8. doi: 10.1002/jcp.22690.

10.

Studying the CCN Proteins in Fibrosis.

Hutchenreuther J, Leask A, Thompson K.

Methods Mol Biol. 2017;1489:423-429.

PMID:
27734394
11.

Rac inhibition reverses the phenotype of fibrotic fibroblasts.

Xu SW, Liu S, Eastwood M, Sonnylal S, Denton CP, Abraham DJ, Leask A.

PLoS One. 2009 Oct 13;4(10):e7438. doi: 10.1371/journal.pone.0007438.

12.
13.

Connective tissue growth factor/CCN2-null mouse embryonic fibroblasts retain intact transforming growth factor-beta responsiveness.

Mori Y, Hinchcliff M, Wu M, Warner-Blankenship M, M Lyons K, Varga J.

Exp Cell Res. 2008 Mar 10;314(5):1094-104. doi: 10.1016/j.yexcr.2007.12.010. Epub 2007 Dec 23.

14.

Enhanced expression of ephrins and thrombospondins in the dermis of patients with early diffuse systemic sclerosis: potential contribution to perturbed angiogenesis and fibrosis.

Avouac J, Clemessy M, Distler JH, Gasc JM, Ruiz B, Vacher-Lavenu MC, Wipff J, Kahan A, Boileau C, Corvol P, Allanore Y.

Rheumatology (Oxford). 2011 Aug;50(8):1494-504. doi: 10.1093/rheumatology/keq448. Epub 2011 Mar 30.

PMID:
21454305
15.

Skin progenitor cells contribute to bleomycin-induced skin fibrosis.

Liu S, Herault Y, Pavlovic G, Leask A.

Arthritis Rheumatol. 2014 Mar;66(3):707-13. doi: 10.1002/art.38276.

16.

Systemic sclerosis endothelial cells recruit and activate dermal fibroblasts by induction of a connective tissue growth factor (CCN2)/transforming growth factor β-dependent mesenchymal-to-mesenchymal transition.

Serratì S, Chillà A, Laurenzana A, Margheri F, Giannoni E, Magnelli L, Chiarugi P, Dotor J, Feijoo E, Bazzichi L, Bombardieri S, Kahaleh B, Fibbi G, Del Rosso M.

Arthritis Rheum. 2013 Jan;65(1):258-69. doi: 10.1002/art.37705.

17.

Reduced expression of connective tissue growth factor (CTGF/CCN2) mediates collagen loss in chronologically aged human skin.

Quan T, Shao Y, He T, Voorhees JJ, Fisher GJ.

J Invest Dermatol. 2010 Feb;130(2):415-24. doi: 10.1038/jid.2009.224. Epub 2009 Jul 30.

18.

Akt inhibition up-regulates MMP1 through a CCN2-dependent pathway in human dermal fibroblasts.

Bujor AM, Nakerakanti S, Morris E, Hant FN, Trojanowska M.

Exp Dermatol. 2010 Apr;19(4):347-54. doi: 10.1111/j.1600-0625.2010.01065.x. Epub 2010 Feb 25.

19.

Lipoic acid plays a role in scleroderma: insights obtained from scleroderma dermal fibroblasts.

Tsou PS, Balogh B, Pinney AJ, Zakhem G, Lozier A, Amin MA, Stinson WA, Schiopu E, Khanna D, Fox DA, Koch AE.

Arthritis Res Ther. 2014;16(5):411.

20.

Negative regulation of myofibroblast differentiation by PTEN (Phosphatase and Tensin Homolog Deleted on chromosome 10).

White ES, Atrasz RG, Hu B, Phan SH, Stambolic V, Mak TW, Hogaboam CM, Flaherty KR, Martinez FJ, Kontos CD, Toews GB.

Am J Respir Crit Care Med. 2006 Jan 1;173(1):112-21. Epub 2005 Sep 22.

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