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Items: 1 to 20 of 126

1.

Synthesis and antiproliferative evaluation of novel benzoimidazole-contained oxazole-bridged analogs of combretastatin A-4.

Zhou J, Jin J, Zhang Y, Yin Y, Chen X, Xu B.

Eur J Med Chem. 2013 Oct;68:222-32. doi: 10.1016/j.ejmech.2013.08.006. Epub 2013 Aug 13.

PMID:
23981529
2.

New oxazole-bridged combretastatin A-4 analogues as potential vascular-disrupting agents.

Mahal K, Biersack B, Schobert R.

Int J Clin Pharmacol Ther. 2013 Jan;51(1):41-3. No abstract available.

3.

Design, synthesis and biological evaluation of dihydronaphthalene and benzosuberene analogs of the combretastatins as inhibitors of tubulin polymerization in cancer chemotherapy.

Sriram M, Hall JJ, Grohmann NC, Strecker TE, Wootton T, Franken A, Trawick ML, Pinney KG.

Bioorg Med Chem. 2008 Sep 1;16(17):8161-71. doi: 10.1016/j.bmc.2008.07.050. Epub 2008 Jul 24.

PMID:
18722127
4.

Combretastatin linked 1,3,4-oxadiazole conjugates as a Potent Tubulin Polymerization inhibitors.

Kamal A, Srikanth PS, Vishnuvardhan MV, Kumar GB, Suresh Babu K, Hussaini SM, Kapure JS, Alarifi A.

Bioorg Chem. 2016 Apr;65:126-36. doi: 10.1016/j.bioorg.2016.02.007. Epub 2016 Feb 26.

PMID:
26943479
5.

Synthesis and biological evaluation of 1,2,3-triazole linked aminocombretastatin conjugates as mitochondrial mediated apoptosis inducers.

Kamal A, Shaik B, Nayak VL, Nagaraju B, Kapure JS, Shaheer Malik M, Shaik TB, Prasad B.

Bioorg Med Chem. 2014 Oct 1;22(19):5155-67. doi: 10.1016/j.bmc.2014.08.008. Epub 2014 Aug 19.

PMID:
25192811
6.

Correlation of hydrogen-bonding propensity and anticancer profile of tetrazole-tethered combretastatin analogues.

Jedhe GS, Paul D, Gonnade RG, Santra MK, Hamel E, Nguyen TL, Sanjayan GJ.

Bioorg Med Chem Lett. 2013 Aug 15;23(16):4680-4. doi: 10.1016/j.bmcl.2013.06.004. Epub 2013 Jun 12.

7.

Combretastatin dinitrogen-substituted stilbene analogues as tubulin-binding and vascular-disrupting agents.

Siles R, Ackley JF, Hadimani MB, Hall JJ, Mugabe BE, Guddneppanavar R, Monk KA, Chapuis JC, Pettit GR, Chaplin DJ, Edvardsen K, Trawick ML, Garner CM, Pinney KG.

J Nat Prod. 2008 Mar;71(3):313-20. doi: 10.1021/np070377j. Epub 2008 Feb 28.

PMID:
18303849
8.

Design, synthesis, and biological evaluation of novel alkylsulfanyl-1,2,4-triazoles as cis-restricted combretastatin A-4 analogues.

Li YH, Zhang B, Yang HK, Li Q, Diao PC, You WW, Zhao PL.

Eur J Med Chem. 2017 Jan 5;125:1098-1106. doi: 10.1016/j.ejmech.2016.10.051. Epub 2016 Oct 24.

PMID:
27810596
9.

Design, synthesis, biological evaluation and molecular modeling of 1,3,4-oxadiazoline analogs of combretastatin-A4 as novel antitubulin agents.

Hu Y, Lu X, Chen K, Yan R, Li QS, Zhu HL.

Bioorg Med Chem. 2012 Jan 15;20(2):903-9. doi: 10.1016/j.bmc.2011.11.057. Epub 2011 Dec 3.

PMID:
22192936
10.

Synthesis and biological evaluation of 3-(trimethoxyphenyl)-2(3H)-thiazole thiones as combretastatin analogs.

Banimustafa M, Kheirollahi A, Safavi M, Kabudanian Ardestani S, Aryapour H, Foroumadi A, Emami S.

Eur J Med Chem. 2013;70:692-702. doi: 10.1016/j.ejmech.2013.10.046. Epub 2013 Oct 25.

PMID:
24219991
11.

Synthesis and evaluation of diaryl sulfides and diaryl selenide compounds for antitubulin and cytotoxic activity.

dos Santos Edos A, Hamel E, Bai R, Burnett JC, Tozatti CS, Bogo D, Perdomo RT, Antunes AM, Marques MM, Matos Mde F, de Lima DP.

Bioorg Med Chem Lett. 2013 Aug 15;23(16):4669-73. doi: 10.1016/j.bmcl.2013.06.009. Epub 2013 Jun 12.

12.

Design, synthesis and biological studies of novel tubulin inhibitors.

Sun Y, Pandit B, Chettiar SN, Etter JP, Lewis A, Johnsamuel J, Li PK.

Bioorg Med Chem Lett. 2013 Aug 1;23(15):4465-8. doi: 10.1016/j.bmcl.2013.04.078. Epub 2013 May 7.

PMID:
23790539
13.

Synthesis and evaluation of benzimidazole carbamates bearing indole moieties for antiproliferative and antitubulin activities.

Guan Q, Han C, Zuo D, Zhai M, Li Z, Zhang Q, Zhai Y, Jiang X, Bao K, Wu Y, Zhang W.

Eur J Med Chem. 2014 Nov 24;87:306-15. doi: 10.1016/j.ejmech.2014.09.071. Epub 2014 Sep 28.

PMID:
25262051
14.

Discovery of azaisoerianin derivatives as potential antitumors agents.

Soussi MA, Provot O, Bernadat G, Bignon J, Wdzieczak-Bakala J, Desravines D, Dubois J, Brion JD, Messaoudi S, Alami M.

Eur J Med Chem. 2014 May 6;78:178-89. doi: 10.1016/j.ejmech.2014.03.032. Epub 2014 Mar 13.

PMID:
24681982
15.

Synthesis and antiproliferative activity of conformationally restricted 1,2,3-triazole analogues of combretastatins in the sea urchin embryo model and against human cancer cell lines.

Demchuk DV, Samet AV, Chernysheva NB, Ushkarov VI, Stashina GA, Konyushkin LD, Raihstat MM, Firgang SI, Philchenkov AA, Zavelevich MP, Kuiava LM, Chekhun VF, Blokhin DY, Kiselyov AS, Semenova MN, Semenov VV.

Bioorg Med Chem. 2014 Jan 15;22(2):738-55. doi: 10.1016/j.bmc.2013.12.015. Epub 2013 Dec 12.

PMID:
24387982
16.

Combretastatin-like chalcones as inhibitors of microtubule polymerization. Part 1: synthesis and biological evaluation of antivascular activity.

Ducki S, Rennison D, Woo M, Kendall A, Chabert JF, McGown AT, Lawrence NJ.

Bioorg Med Chem. 2009 Nov 15;17(22):7698-710. doi: 10.1016/j.bmc.2009.09.039. Epub 2009 Sep 25.

PMID:
19837593
17.

N-aryl-6-methoxy-1,2,3,4-tetrahydroquinolines: a novel class of antitumor agents targeting the colchicine site on tubulin.

Wang XF, Wang SB, Ohkoshi E, Wang LT, Hamel E, Qian K, Morris-Natschke SL, Lee KH, Xie L.

Eur J Med Chem. 2013 Sep;67:196-207. doi: 10.1016/j.ejmech.2013.06.041. Epub 2013 Jun 29.

18.

Synthesis and biological evaluation of novel 3,4-diaryl-1,2,5-selenadiazol analogues of combretastatin A-4.

Guan Q, Yang F, Guo D, Xu J, Jiang M, Liu C, Bao K, Wu Y, Zhang W.

Eur J Med Chem. 2014 Nov 24;87:1-9. doi: 10.1016/j.ejmech.2014.09.046. Epub 2014 Sep 16.

PMID:
25233100
19.

Synthesis and cytotoxic evaluation of combretafurans, potential scaffolds for dual-action antitumoral agents.

Pirali T, Busacca S, Beltrami L, Imovilli D, Pagliai F, Miglio G, Massarotti A, Verotta L, Tron GC, Sorba G, Genazzani AA.

J Med Chem. 2006 Aug 24;49(17):5372-6.

PMID:
16913727
20.

Synthesis and antitumor activity of 1,5-disubstituted 1,2,4-triazoles as cis-restricted combretastatin analogues.

Romagnoli R, Baraldi PG, Cruz-Lopez O, Lopez Cara C, Carrion MD, Brancale A, Hamel E, Chen L, Bortolozzi R, Basso G, Viola G.

J Med Chem. 2010 May 27;53(10):4248-58. doi: 10.1021/jm100245q.

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