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Items: 1 to 20 of 95

1.

Selective inhibitors of bacterial t-RNA-(N(1)G37) methyltransferase (TrmD) that demonstrate novel ordering of the lid domain.

Hill PJ, Abibi A, Albert R, Andrews B, Gagnon MM, Gao N, Grebe T, Hajec LI, Huang J, Livchak S, Lahiri SD, McKinney DC, Thresher J, Wang H, Olivier N, Buurman ET.

J Med Chem. 2013 Sep 26;56(18):7278-88. doi: 10.1021/jm400718n. Epub 2013 Sep 17.

PMID:
23981144
2.

Structural basis for methyl-donor-dependent and sequence-specific binding to tRNA substrates by knotted methyltransferase TrmD.

Ito T, Masuda I, Yoshida K, Goto-Ito S, Sekine S, Suh SW, Hou YM, Yokoyama S.

Proc Natl Acad Sci U S A. 2015 Aug 4;112(31):E4197-205. doi: 10.1073/pnas.1422981112. Epub 2015 Jul 16.

3.

Differentiating analogous tRNA methyltransferases by fragments of the methyl donor.

Lahoud G, Goto-Ito S, Yoshida K, Ito T, Yokoyama S, Hou YM.

RNA. 2011 Jul;17(7):1236-46. doi: 10.1261/rna.2706011. Epub 2011 May 20.

4.

Crystal structure of tRNA(m1G37)methyltransferase: insights into tRNA recognition.

Ahn HJ, Kim HW, Yoon HJ, Lee BI, Suh SW, Yang JK.

EMBO J. 2003 Jun 2;22(11):2593-603.

5.

Isolation and characterization of the human tRNA-(N1G37) methyltransferase (TRM5) and comparison to the Escherichia coli TrmD protein.

Brulé H, Elliott M, Redlak M, Zehner ZE, Holmes WM.

Biochemistry. 2004 Jul 20;43(28):9243-55.

PMID:
15248782
6.

Recognition of guanosine by dissimilar tRNA methyltransferases.

Sakaguchi R, Giessing A, Dai Q, Lahoud G, Liutkeviciute Z, Klimasauskas S, Piccirilli J, Kirpekar F, Hou YM.

RNA. 2012 Sep;18(9):1687-701. doi: 10.1261/rna.032029.111. Epub 2012 Jul 30.

7.

The substrate specificity of tRNA (m1G37) methyltransferase (TrmD) from Aquifex aeolicus.

Takeda H, Toyooka T, Ikeuchi Y, Yokobori S, Okadome K, Takano F, Oshima T, Suzuki T, Endo Y, Hori H.

Genes Cells. 2006 Dec;11(12):1353-65.

8.

Control of catalytic cycle by a pair of analogous tRNA modification enzymes.

Christian T, Lahoud G, Liu C, Hou YM.

J Mol Biol. 2010 Jul 9;400(2):204-17. doi: 10.1016/j.jmb.2010.05.003. Epub 2010 May 7.

9.

Crystallization and preliminary X-ray crystallographic analysis of tRNA(m1G37)methyltransferase from Haemophilus influenzae.

Kim HW, Ahn HJ, Yoon HJ, Kim HW, Baek SH, Suh SW.

Acta Crystallogr D Biol Crystallogr. 2003 Jan;59(Pt 1):183-4. Epub 2002 Dec 19.

PMID:
12499565
10.

Kinetic Analysis of tRNA Methyltransferases.

Hou YM, Masuda I.

Methods Enzymol. 2015;560:91-116. doi: 10.1016/bs.mie.2015.04.012. Epub 2015 Jun 2.

11.

Insights into catalysis by a knotted TrmD tRNA methyltransferase.

Elkins PA, Watts JM, Zalacain M, van Thiel A, Vitazka PR, Redlak M, Andraos-Selim C, Rastinejad F, Holmes WM.

J Mol Biol. 2003 Nov 7;333(5):931-49.

PMID:
14583191
12.

Conservation of structure and mechanism by Trm5 enzymes.

Christian T, Gamper H, Hou YM.

RNA. 2013 Sep;19(9):1192-9. doi: 10.1261/rna.039503.113. Epub 2013 Jul 25.

13.

Distinct determinants of tRNA recognition by the TrmD and Trm5 methyl transferases.

Christian T, Hou YM.

J Mol Biol. 2007 Oct 26;373(3):623-32. Epub 2007 Aug 21.

14.

Mechanism of N-methylation by the tRNA m1G37 methyltransferase Trm5.

Christian T, Lahoud G, Liu C, Hoffmann K, Perona JJ, Hou YM.

RNA. 2010 Dec;16(12):2484-92. doi: 10.1261/rna.2376210. Epub 2010 Oct 27.

15.

The temperature sensitivity of a mutation in the essential tRNA modification enzyme tRNA methyltransferase D (TrmD).

Masuda I, Sakaguchi R, Liu C, Gamper H, Hou YM.

J Biol Chem. 2013 Oct 4;288(40):28987-96. doi: 10.1074/jbc.M113.485797. Epub 2013 Aug 28.

16.

Methyl transfer by substrate signaling from a knotted protein fold.

Christian T, Sakaguchi R, Perlinska AP, Lahoud G, Ito T, Taylor EA, Yokoyama S, Sulkowska JI, Hou YM.

Nat Struct Mol Biol. 2016 Oct;23(10):941-948. doi: 10.1038/nsmb.3282. Epub 2016 Aug 29.

17.

Catalysis by the second class of tRNA(m1G37) methyl transferase requires a conserved proline.

Christian T, Evilia C, Hou YM.

Biochemistry. 2006 Jun 20;45(24):7463-73.

18.

Ligand-mediated anticodon conformational changes occur during tRNA methylation by a TrmD methyltransferase.

Watts JM, Gabruzsk J, Holmes WM.

Biochemistry. 2005 May 3;44(17):6629-39.

PMID:
15850396
19.

Peptidomimetic inhibitors of bacterial peptide deformylase.

East SP, Ayscough A, Toogood-Johnson I, Taylor S, Thomas W.

Bioorg Med Chem Lett. 2011 Jul 1;21(13):4032-5. doi: 10.1016/j.bmcl.2011.04.132. Epub 2011 May 11.

PMID:
21621999
20.

Antimicrobial N-(2-chlorobenzyl)-substituted hydroxamate is an inhibitor of 1-deoxy-D-xylulose 5-phosphate synthase.

Hayashi D, Kato N, Kuzuyama T, Sato Y, Ohkanda J.

Chem Commun (Camb). 2013 Jun 21;49(49):5535-7. doi: 10.1039/c3cc40758f.

PMID:
23476925

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